LOV_DROME
ID LOV_DROME Reviewed; 1046 AA.
AC P14083; A4UZV7; Q0E8V9; Q24002; Q7JPM0; Q7KA34; Q9U1H2; Q9W0W2;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Protein jim lovell;
DE AltName: Full=Protein TKR;
DE AltName: Full=Tyrosine kinase-related;
DE Short=dTKR;
GN Name=lov; Synonyms=Tkr; ORFNames=CG16778;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=11973274; DOI=10.1242/dev.129.10.2419;
RA Couderc J.-L.G., Godt D., Zollman S., Chen J., Li M., Tiong S.,
RA Cramton S.E., Sahut-Barnola I., Laski F.A.;
RT "The bric a brac locus consists of two paralogous genes encoding BTB/POZ
RT domain proteins and acts as a homeotic and morphogenetic regulator of
RT imaginal development in Drosophila.";
RL Development 129:2419-2433(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-227.
RX PubMed=7938017; DOI=10.1073/pnas.91.22.10717;
RA Zollman S., Godt D., Prive G.G., Couderc J.-L., Laski F.A.;
RT "The BTB domain, found primarily in zinc finger proteins, defines an
RT evolutionarily conserved family that includes several developmentally
RT regulated genes in Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:10717-10721(1994).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 272-1046, AND TISSUE SPECIFICITY.
RX PubMed=3428600; DOI=10.1101/gad.1.8.862;
RA Haller J., Cote S., Broenner G., Jaeckle H.;
RT "Dorsal and neural expression of a tyrosine kinase-related Drosophila gene
RT during embryonic development.";
RL Genes Dev. 1:862-867(1987).
RN [7]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16631157; DOI=10.1016/j.ydbio.2006.03.016;
RA Wheeler S.R., Kearney J.B., Guardiola A.R., Crews S.T.;
RT "Single-cell mapping of neural and glial gene expression in the developing
RT Drosophila CNS midline cells.";
RL Dev. Biol. 294:509-524(2006).
CC -!- FUNCTION: Has a regulatory role during midline cell development.
CC {ECO:0000269|PubMed:16631157}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320}.
CC -!- TISSUE SPECIFICITY: Initially expressed at blastoderm stage, transient
CC accumulation at dorso-lateral positions of the embryo and differences
CC along the longitudinal axis. At later stages of embryogenesis,
CC expression is found exclusively in neural anlagen. Expressed in 4
CC posterior-most ventral unpaired median interneurons (VUM) neurons, VUM
CC interneurons and one progeny of the median neuroblast (MNB).
CC {ECO:0000269|PubMed:16631157, ECO:0000269|PubMed:3428600}.
CC -!- CAUTION: Was originally thought to be a kinase on the basis of weak and
CC non-significant similarities. {ECO:0000305|PubMed:3428600}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB64389.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AJ252174; CAB64389.1; ALT_FRAME; mRNA.
DR EMBL; AE013599; AAG22201.2; -; Genomic_DNA.
DR EMBL; AE013599; AAM68329.1; -; Genomic_DNA.
DR EMBL; AE013599; AAX52689.1; -; Genomic_DNA.
DR EMBL; AY122101; AAM52613.1; -; mRNA.
DR EMBL; U14400; AAA50835.1; -; Genomic_DNA.
DR PIR; A27041; A27041.
DR RefSeq; NP_001014554.1; NM_001014554.3.
DR RefSeq; NP_001286876.1; NM_001299947.1.
DR RefSeq; NP_523865.2; NM_079141.4.
DR RefSeq; NP_611994.3; NM_138150.4.
DR RefSeq; NP_665704.1; NM_145761.2.
DR AlphaFoldDB; P14083; -.
DR SMR; P14083; -.
DR BioGRID; 63575; 3.
DR IntAct; P14083; 5.
DR MINT; P14083; -.
DR STRING; 7227.FBpp0072359; -.
DR PaxDb; P14083; -.
DR DNASU; 38007; -.
DR EnsemblMetazoa; FBtr0072457; FBpp0072359; FBgn0266129.
DR EnsemblMetazoa; FBtr0072458; FBpp0072360; FBgn0266129.
DR EnsemblMetazoa; FBtr0100126; FBpp0099472; FBgn0266129.
DR EnsemblMetazoa; FBtr0343605; FBpp0310200; FBgn0266129.
DR GeneID; 38007; -.
DR KEGG; dme:Dmel_CG16778; -.
DR CTD; 38007; -.
DR FlyBase; FBgn0266129; lov.
DR VEuPathDB; VectorBase:FBgn0266129; -.
DR eggNOG; ENOG502RG1U; Eukaryota.
DR HOGENOM; CLU_008582_0_0_1; -.
DR InParanoid; P14083; -.
DR OMA; HDFALNK; -.
DR OrthoDB; 1229475at2759; -.
DR PhylomeDB; P14083; -.
DR BioGRID-ORCS; 38007; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38007; -.
DR PRO; PR:P14083; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0266129; Expressed in ectoderm anlage and 45 other tissues.
DR ExpressionAtlas; P14083; baseline and differential.
DR Genevisible; P14083; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042332; P:gravitaxis; IMP:FlyBase.
DR GO; GO:0030536; P:larval feeding behavior; IMP:FlyBase.
DR GO; GO:0008346; P:larval walking behavior; IMP:FlyBase.
DR GO; GO:0008049; P:male courtship behavior; IMP:FlyBase.
DR GO; GO:0048060; P:negative gravitaxis; IMP:FlyBase.
DR GO; GO:0048477; P:oogenesis; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007418; P:ventral midline development; IMP:UniProtKB.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF05225; HTH_psq; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..1046
FT /note="Protein jim lovell"
FT /id="PRO_0000072552"
FT DOMAIN 140..205
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 781..833
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT REGION 54..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 998..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..76
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..433
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..715
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..882
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 64
FT /note="P -> L (in Ref. 1; CAB64389)"
FT /evidence="ECO:0000305"
FT CONFLICT 69
FT /note="P -> H (in Ref. 1; CAB64389)"
FT /evidence="ECO:0000305"
FT CONFLICT 72..73
FT /note="PP -> LL (in Ref. 1; CAB64389)"
FT /evidence="ECO:0000305"
FT CONFLICT 328
FT /note="D -> H (in Ref. 1; CAB64389 and 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 365
FT /note="Q -> R (in Ref. 1; CAB64389 and 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 395
FT /note="E -> Q (in Ref. 1; CAB64389 and 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 399
FT /note="D -> N (in Ref. 1; CAB64389 and 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 402
FT /note="R -> S (in Ref. 1; CAB64389 and 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 590
FT /note="Q -> E (in Ref. 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 663..664
FT /note="SM -> MS (in Ref. 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 672..675
FT /note="Missing (in Ref. 1; CAB64389 and 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 691..692
FT /note="SP -> PS (in Ref. 6)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1046 AA; 112308 MW; 97864E59A744FFE1 CRC64;
MLKDAHQKLI KHRQSTKLSM TDFACQAAPV KQPLPLELPL PLSVQLQLLA KTPTSDHAPM
HSTPPTTPPT PPPLPLNMSQ SASAVTEAAT PENSLPATPP SEGALAVPSA PQDHYSLRWN
NHQNHILRAF DALLKTKTLV DVTLVCAETS IRAHKMVLSA CSPFFQRVFA ETPCKHPVIV
LKDFRGWVVQ AIVDFMYRGE ISVPQQRLQT LIQAGESLQV RGLVESSVPE HTPTPAASPD
DFGMLDTSML SSTFEDECPT MVRPSKGGKL LMPSARLFGN ASSAIAALGL RRKREQESDR
DLESDQELGG SSPMPRRKQA RPRRRSGDVP HDFTLNKTDA ESLQTVIKHE LLERAERDQE
EAPDQDNSQG EAEKISSSPA KTLVERAKEQ KSMKEEGSDQ PRSLNENHHQ LELDDEDDDD
QDHEEEEEQD IEELIHTTNE LRRQAAAAAA NAAAMSPNPS PCLSDGPEDL CTTKKGKELI
SGPSSSADCE SNNNNSSKLQ DNNQRIMLSL KDIRQLNANP NPTAIHTPTS CSGGNNGLLT
FPPPGLRPPG LPDSPPCHME ALEAQMHAAA AAAVAAAGSG EHPFHHMEHQ MEMSLAAAAA
AAAMHQREPR DPRDGRDHNA FASNLLGPMG MPPFGGHNGG HPGNSGPGNG CPGQAAHERL
EESMNRLSKE LGKEFGKEFG KEFGKEFGPA SPMSLQGPFN APDGPPHPPS PLPFPGMSSA
MTLTPPHMFG LDSPLGLFPP GIDPGKLYNP LMEMSDPRDM PGGPPPFLKK KMPRPKGQHS
APRGGPPRSW TNTELTEALQ HVWNKKMTTS QASRIFGIPY NSLLMYVRGK YGKSLKLEQL
RKDCISGPPI EMLQMGIGGG SGGSTKNEKS KERKEKEKDK NSMSSNGSGG SANSQGGAPT
SGSGPMQHSG ELGPMGQLDL DLGLPLGPPG GPRSNSSEPD LLSAPNALFN PFNPQGFYPD
FSGGFPGLPL SMLNLLPPAE RHHAAAAMHH LGVSMDEDCK SVGSKQSSSV DEDYSGPGIP
LSLEHRREIS ATGPPLTPSN GGTGHD
