ID   LOX10_HELTR             Reviewed;         184 AA.
AC   P42584;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Homeobox protein LOX10;
DE   Flags: Fragment;
GN   Name=LOX10;
OS   Helobdella triserialis (Leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7915671; DOI=10.1242/dev.118.3.877;
RA   Nardelli-Haefliger D., Shankland M.;
RT   "Lox10, a member of the NK-2 homeobox gene class, is expressed in a
RT   segmental pattern in the endoderm and in the cephalic nervous system of the
RT   leech Helobdella.";
RL   Development 118:877-892(1993).
CC   -!- FUNCTION: May play a role in patterning the gut.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in a segmental pattern in the endoderm
CC       and in the cephalic nervous system.
CC   -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
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DR   EMBL; Z22635; CAA80344.1; -; Genomic_DNA.
DR   PIR; S35751; S35751.
DR   AlphaFoldDB; P42584; -.
DR   SMR; P42584; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           <1..184
FT                   /note="Homeobox protein LOX10"
FT                   /id="PRO_0000049170"
FT   DNA_BIND        76..135
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   184 AA;  20849 MW;  C6F936FA782B5217 CRC64;
     KIVSRWMGSQ NNHQQTHPNH HHHLPPLQHH ANNYFPMPLS TYYPPDSSVP LPFPSPAGVN
     STQAPFNPSQ FCFSHRRKRR ILFSQAQIYE LERRFRQQKY LSAPEREHLA TFIGLTPTQV
     KIWFQNHRYK TKKSKKESKN SPSSSSMTSS SSASNKVAST THSPKVSSNG GNGSNTTNNN
     NKPG