LOZEN_DROME
ID LOZEN_DROME Reviewed; 826 AA.
AC Q9W349; Q24183; Q9NHX9;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Protein lozenge;
GN Name=lz; ORFNames=CG1689;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=8675007; DOI=10.1101/gad.10.10.1194;
RA Daga A., Karlovich C.A., Dumstrei K., Banerjee U.;
RT "Patterning of cells in the Drosophila eye by Lozenge, which shares
RT homologous domains with AML1.";
RL Genes Dev. 10:1194-1205(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12111211; DOI=10.1007/s00427-002-0241-4;
RA Behan K.J., Nichols C.D., Cheung T.L., Farlow A., Hogan B.M., Batterham P.,
RA Pollock J.A.;
RT "Yan regulates Lozenge during Drosophila eye development.";
RL Dev. Genes Evol. 212:267-276(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP FUNCTION.
RX PubMed=10707973; DOI=10.1016/s0896-6273(00)80872-7;
RA Goulding S.E., zur Lage P., Jarman A.P.;
RT "Amos, a proneural gene for Drosophila olfactory sense organs that is
RT regulated by lozenge.";
RL Neuron 25:69-78(2000).
RN [6]
RP FUNCTION.
RX PubMed=15879554; DOI=10.1101/gad.1298105;
RA Wildonger J., Sosinsky A., Honig B., Mann R.S.;
RT "Lozenge directly activates argos and klumpfuss to regulate programmed cell
RT death.";
RL Genes Dev. 19:1034-1039(2005).
CC -!- FUNCTION: Involved in prepatterning photoreceptor precursors in the
CC developing eye; in the larval eye disk it defines a subset of cells as
CC an equipotential group that is competent to respond to the sevenless
CC developmental signal and another subset that confer proper
CC photoreceptor identity by positively regulating the homeo box gene Bar.
CC Involved in the aop/pnt dynamic in a Ras-dependent manner to regulate
CC pros expression. Promotes apoptosis in the pupal eye by directly
CC activating aos and klu. Also modulates hid- and rpr-mediated cell
CC death. Regulates amos function in olfactory sensilla development.
CC {ECO:0000269|PubMed:10707973, ECO:0000269|PubMed:12111211,
CC ECO:0000269|PubMed:15879554, ECO:0000269|PubMed:8675007}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00399}.
CC -!- TISSUE SPECIFICITY: Expressed in the pupal eye during programmed cell
CC death. {ECO:0000269|PubMed:12111211}.
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DR EMBL; U47849; AAC47196.2; -; mRNA.
DR EMBL; AF217651; AAF35308.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF46486.2; -; Genomic_DNA.
DR RefSeq; NP_511099.2; NM_078544.3.
DR AlphaFoldDB; Q9W349; -.
DR SMR; Q9W349; -.
DR BioGRID; 58331; 22.
DR ELM; Q9W349; -.
DR STRING; 7227.FBpp0071255; -.
DR PaxDb; Q9W349; -.
DR EnsemblMetazoa; FBtr0071320; FBpp0071255; FBgn0002576.
DR GeneID; 31883; -.
DR KEGG; dme:Dmel_CG1689; -.
DR UCSC; CG1689-RA; d. melanogaster.
DR CTD; 17106; -.
DR FlyBase; FBgn0002576; lz.
DR VEuPathDB; VectorBase:FBgn0002576; -.
DR eggNOG; KOG3982; Eukaryota.
DR GeneTree; ENSGT00940000159255; -.
DR HOGENOM; CLU_016277_0_0_1; -.
DR InParanoid; Q9W349; -.
DR OMA; YNNAAAW; -.
DR OrthoDB; 1130963at2759; -.
DR PhylomeDB; Q9W349; -.
DR Reactome; R-DME-549127; Organic cation transport.
DR Reactome; R-DME-8878166; Transcriptional regulation by RUNX2.
DR Reactome; R-DME-8931987; RUNX1 regulates estrogen receptor mediated transcription.
DR Reactome; R-DME-8934593; Regulation of RUNX1 Expression and Activity.
DR Reactome; R-DME-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR Reactome; R-DME-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-DME-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
DR Reactome; R-DME-8939245; RUNX1 regulates transcription of genes involved in BCR signaling.
DR Reactome; R-DME-8939246; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells.
DR Reactome; R-DME-8939247; RUNX1 regulates transcription of genes involved in interleukin signaling.
DR Reactome; R-DME-8939902; Regulation of RUNX2 expression and activity.
DR Reactome; R-DME-8940973; RUNX2 regulates osteoblast differentiation.
DR Reactome; R-DME-8941326; RUNX2 regulates bone development.
DR Reactome; R-DME-8941855; RUNX3 regulates CDKN1A transcription.
DR Reactome; R-DME-8941858; Regulation of RUNX3 expression and activity.
DR Reactome; R-DME-8951430; RUNX3 regulates WNT signaling.
DR Reactome; R-DME-8951671; RUNX3 regulates YAP1-mediated transcription.
DR Reactome; R-DME-8951936; RUNX3 regulates p14-ARF.
DR Reactome; R-DME-9018519; Estrogen-dependent gene expression.
DR SignaLink; Q9W349; -.
DR BioGRID-ORCS; 31883; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 31883; -.
DR PRO; PR:Q9W349; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0002576; Expressed in crystal cell primordium (Drosophila) and 12 other tissues.
DR ExpressionAtlas; Q9W349; baseline and differential.
DR Genevisible; Q9W349; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:FlyBase.
DR GO; GO:0007469; P:antennal development; TAS:FlyBase.
DR GO; GO:0042675; P:compound eye cone cell differentiation; IMP:FlyBase.
DR GO; GO:0048749; P:compound eye development; IMP:FlyBase.
DR GO; GO:0042688; P:crystal cell differentiation; IMP:FlyBase.
DR GO; GO:0035165; P:embryonic crystal cell differentiation; IMP:FlyBase.
DR GO; GO:0035163; P:embryonic hemocyte differentiation; IMP:FlyBase.
DR GO; GO:0035162; P:embryonic hemopoiesis; IMP:FlyBase.
DR GO; GO:0048592; P:eye morphogenesis; IMP:FlyBase.
DR GO; GO:0007486; P:imaginal disc-derived female genitalia development; IMP:FlyBase.
DR GO; GO:0035168; P:larval lymph gland hemocyte differentiation; TAS:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:FlyBase.
DR GO; GO:0046672; P:positive regulation of compound eye retinal cell programmed cell death; IMP:UniProtKB.
DR GO; GO:0042691; P:positive regulation of crystal cell differentiation; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:0045467; P:R7 cell development; IMP:FlyBase.
DR GO; GO:0035314; P:scab formation; IMP:FlyBase.
DR GO; GO:0016360; P:sensory organ precursor cell fate determination; TAS:FlyBase.
DR GO; GO:0035211; P:spermathecum morphogenesis; TAS:FlyBase.
DR GO; GO:0042060; P:wound healing; IMP:FlyBase.
DR Gene3D; 2.60.40.720; -; 1.
DR InterPro; IPR000040; AML1_Runt.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
DR InterPro; IPR013524; Runt_dom.
DR PANTHER; PTHR11950; PTHR11950; 1.
DR Pfam; PF00853; Runt; 1.
DR PRINTS; PR00967; ONCOGENEAML1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS51062; RUNT; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..826
FT /note="Protein lozenge"
FT /id="PRO_0000174666"
FT DOMAIN 275..403
FT /note="Runt"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00399"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..142
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 8
FT /note="A -> V (in Ref. 1; AAC47196)"
FT /evidence="ECO:0000305"
FT CONFLICT 16
FT /note="S -> F (in Ref. 1; AAC47196)"
FT /evidence="ECO:0000305"
FT CONFLICT 252
FT /note="N -> NNNN (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 341..342
FT /note="EL -> DV (in Ref. 1; AAC47196)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 826 AA; 84722 MW; BCDF558F3E42B5CC CRC64;
MHLHLLAAEK TPPSPSPNPT PTPSASPSGH TGAAGESQLD LASQTESQLQ LGLPLASGYG
LGLGLGLGLG LGLGQELVAD HSTTVAPVSV AGPGRLGRSI NGSGGSHHHH HLHHHYSPYH
HAHPYHPPHP HAPHHHHHHH PPYPYPPAGP HPPAMVTSSS TSPTGNGWSS STGDFKGITA
VATATGGGVG GATQGATAST GATAAEVLAV SSSASVGSSS PTGGASNGTA HSGHSGHTGG
HSSSTASNNN NNGASNSNSN NNNAVHQDLL WMERLVQKRQ QEHPGELVRT SNPYFLCSAL
PAHWRSNKTL PMAFKVVALA EVGDGTYVTI RAGNDENCCA ELRNFTTQMK NDVAKFNDLR
FVGRSGRGKS FTLTITVATS PPQVATYAKA IKVTVDGPRE PRSKTSPTGG PHYRALGLGQ
RPYIDGFPST KALHELESLR RSAKVAAVTT AAAAAATAAS AANAVAAAAA AVAVTPTGGG
GGVAAGGVAG GAGAGLVQQL SSNYSSPNST INSDCQVYKP NAPHIQAAEM MGAGEWTNGS
SSSAAAYYHS HAHHPHAHHA HAHLQHQMAL PPPPPPPAAA PVSVGVGGNG ATMGMGMGVG
VGMGMNHYGG GYDSANSLEA GQYAAHLPAV LPEMHGHGFA TDPYQTAGYG GGNTGGGSAS
KSELDYGGSY NQAWSNGYQN YQYGSCLATA QYGPQAAPPP QPPPPPPVVL CPQLYSTVNQ
NQIHLHLHSS EKLEQYLGTA TSADHLTIGS LTGSSRSSIE IGQDQYHQQV HHAQQQQQQQ
QQQQQVHHPQ QQQVESAGEV GGSGAGGVES AREEDVGDLS QVWRPY
