LP3_BOMMO
ID LP3_BOMMO Reviewed; 256 AA.
AC Q00802; H9J4F6;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2021, sequence version 2.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Low molecular mass lipoprotein 3 {ECO:0000303|Ref.5};
DE Short=Bmlp3 {ECO:0000303|Ref.5};
DE AltName: Full=30 KDa protein 1 {ECO:0000303|PubMed:26078299};
DE Short=Bm30K-1 {ECO:0000303|PubMed:26078299};
DE AltName: Full=30 KDa protein 19G1 {ECO:0000303|PubMed:1883839};
DE Flags: Precursor;
GN Name=LP3 {ECO:0000303|Ref.5};
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091;
RN [1] {ECO:0000312|EMBL:AFC87799.1}
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=26078299; DOI=10.1093/jisesa/iev057;
RA Shi X.F., Li Y.N., Yi Y.Z., Xiao X.G., Zhang Z.F.;
RT "Identification and Characterization of 30 K Protein Genes Found in Bombyx
RT mori (Lepidoptera: Bombycidae) Transcriptome.";
RL J. Insect Sci. 15:71-71(2015).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Tokai X Asahi; TISSUE=Fat body;
RX PubMed=1883839; DOI=10.1016/0167-4781(91)90048-q;
RA Mori S., Izumi S., Tomino S.;
RT "Complete nucleotide sequences of major plasma protein genes of Bombyx
RT mori.";
RL Biochim. Biophys. Acta 1090:129-132(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p50T;
RX PubMed=15591204; DOI=10.1126/science.1102210;
RA Xia Q., Zhou Z., Lu C., Cheng D., Dai F., Li B., Zhao P., Zha X., Cheng T.,
RA Chai C., Pan G., Xu J., Liu C., Lin Y., Qian J., Hou Y., Wu Z., Li G.,
RA Pan M., Li C., Shen Y., Lan X., Yuan L., Li T., Xu H., Yang G., Wan Y.,
RA Zhu Y., Yu M., Shen W., Wu D., Xiang Z., Yu J., Wang J., Li R., Shi J.,
RA Li H., Li G., Su J., Wang X., Li G., Zhang Z., Wu Q., Li J., Zhang Q.,
RA Wei N., Xu J., Sun H., Dong L., Liu D., Zhao S., Zhao X., Meng Q., Lan F.,
RA Huang X., Li Y., Fang L., Li C., Li D., Sun Y., Zhang Z., Yang Z.,
RA Huang Y., Xi Y., Qi Q., He D., Huang H., Zhang X., Wang Z., Li W., Cao Y.,
RA Yu Y., Yu H., Li J., Ye J., Chen H., Zhou Y., Liu B., Wang J., Ye J.,
RA Ji H., Li S., Ni P., Zhang J., Zhang Y., Zheng H., Mao B., Wang W., Ye C.,
RA Li S., Wang J., Wong G.K.-S., Yang H.;
RT "A draft sequence for the genome of the domesticated silkworm (Bombyx
RT mori).";
RL Science 306:1937-1940(2004).
RN [4] {ECO:0007744|PDB:4IY8, ECO:0007744|PDB:4IY9}
RP PROTEIN SEQUENCE OF 18-27, X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF
RP 18-256, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=23613829; DOI=10.1371/journal.pone.0061303;
RA Pietrzyk A.J., Bujacz A., Mueller-Dieckmann J., Lochynska M., Jaskolski M.,
RA Bujacz G.;
RT "Two crystal structures of Bombyx mori lipoprotein 3 - structural
RT characterization of a new 30-kDa lipoprotein family member.";
RL PLoS ONE 8:e61303-e61303(2013).
RN [5] {ECO:0000305}
RP NOMENCLATURE, AND DEVELOPMENTAL STAGE.
RX DOI=10.1111/j.1744-7917.2007.00121.x;
RA Sun Q., Zhao P., Lin Y., Hou Y., Xia Q.-Y., Xiang Z.-H.;
RT "Analysis of the structure and expression of the 30K protein genes in
RT silkworm, Bombyx mori.";
RL Insect Sci. 14:5-14(2007).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23613829,
CC ECO:0000269|PubMed:26078299}.
CC -!- TISSUE SPECIFICITY: Detected in larval hemolymph (at protein level).
CC {ECO:0000269|PubMed:23613829, ECO:0000269|PubMed:26078299}.
CC -!- DEVELOPMENTAL STAGE: Expressed in fat body from the fifth larval instar
CC through to the pupal stage (PubMed:26078299, Ref.5). Highest expression
CC levels are found at the wandering stage which marks the transition from
CC larva to pupa (Ref.5). Expression then declines during later pupal
CC stages (Ref.5). {ECO:0000269|PubMed:26078299, ECO:0000269|Ref.5}.
CC -!- MISCELLANEOUS: This lipoprotein belongs to the group of structurally
CC related '30 kDa proteins' that comprise major protein components of the
CC fifth (and last) instar larvae and of pupae. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the 30 kDa lipoprotein family. {ECO:0000305}.
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DR EMBL; JN977519; AFC87799.1; -; mRNA.
DR EMBL; X54736; CAA38533.1; -; Genomic_DNA.
DR EMBL; BABH01021937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; S17662; S17662.
DR RefSeq; XP_012550498.1; XM_012695044.1.
DR RefSeq; XP_012550504.1; XM_012695050.1.
DR PDB; 4IY8; X-ray; 2.36 A; A/B/C/D=18-256.
DR PDB; 4IY9; X-ray; 2.10 A; A/B=18-256.
DR PDBsum; 4IY8; -.
DR PDBsum; 4IY9; -.
DR AlphaFoldDB; Q00802; -.
DR SMR; Q00802; -.
DR STRING; 7091.BGIBMGA004396-TA; -.
DR EnsemblMetazoa; BGIBMGA004396-RA; BGIBMGA004396-TA; BGIBMGA004396.
DR GeneID; 693044; -.
DR CTD; 693044; -.
DR HOGENOM; CLU_053201_2_0_1; -.
DR OrthoDB; 1430900at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.10.2400; -; 1.
DR InterPro; IPR004943; Lipoprotein_11.
DR InterPro; IPR042046; Lipoprotein_11_N.
DR Pfam; PF03260; Lipoprotein_11; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Lipoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000269|PubMed:23613829"
FT CHAIN 18..256
FT /note="Low molecular mass lipoprotein 3"
FT /id="PRO_0000021572"
FT CONFLICT 132
FT /note="A -> R (in Ref. 2; CAA38533)"
FT /evidence="ECO:0000305"
FT HELIX 19..21
FT /evidence="ECO:0007829|PDB:4IY8"
FT HELIX 24..36
FT /evidence="ECO:0007829|PDB:4IY9"
FT HELIX 40..52
FT /evidence="ECO:0007829|PDB:4IY9"
FT HELIX 56..68
FT /evidence="ECO:0007829|PDB:4IY9"
FT HELIX 73..83
FT /evidence="ECO:0007829|PDB:4IY9"
FT HELIX 87..93
FT /evidence="ECO:0007829|PDB:4IY9"
FT HELIX 96..102
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 107..111
FT /evidence="ECO:0007829|PDB:4IY9"
FT TURN 112..115
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 116..120
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 125..128
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 130..137
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 139..141
FT /evidence="ECO:0007829|PDB:4IY9"
FT HELIX 142..144
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 146..153
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 156..163
FT /evidence="ECO:0007829|PDB:4IY9"
FT TURN 164..167
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 168..176
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 182..188
FT /evidence="ECO:0007829|PDB:4IY9"
FT HELIX 193..195
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 197..204
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 207..214
FT /evidence="ECO:0007829|PDB:4IY9"
FT TURN 215..217
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 220..223
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 233..238
FT /evidence="ECO:0007829|PDB:4IY9"
FT HELIX 246..249
FT /evidence="ECO:0007829|PDB:4IY9"
FT STRAND 251..254
FT /evidence="ECO:0007829|PDB:4IY9"
SQ SEQUENCE 256 AA; 29414 MW; 413A8F8D30C94B0A CRC64;
MKPAIVILCL FVASLYAADS DVPNDILEEQ LYNSVVVADY DSAVEKSKHL YEEKKSEVIT
NVVNKLIRNN KMNCMEYAYQ LWLQGSKDIV RDCFPVEFRL IFAENAIKLM YKRDGLALTL
SNDVQGDDGR PAYGDGKDKT SPRVSWKLIA LWENNKVYFK ILNTERNQYL VLGVGTNWNG
DHMAFGVNSV DSFRAQWYLQ PAKYDNDVLF YIYNREYSKA LTLSRTVEPS GHRMAWGYNG
RVIGSPEHYA WGIKAF
