ID   LP4_BOMMO               Reviewed;         263 AA.
AC   Q00801; H9J4F5;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2021, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Low molecular mass lipoprotein 4 {ECO:0000303|Ref.4};
DE            Short=Bmlp4 {ECO:0000303|Ref.4};
DE   AltName: Full=30 KDa lipoprotein 6 {ECO:0000303|PubMed:26078299};
DE            Short=Bm30K-6 {ECO:0000303|PubMed:26078299};
DE   AltName: Full=30 kDa lipoprotein 21G1 {ECO:0000303|PubMed:1883839};
DE   Flags: Precursor;
GN   Name=LP4 {ECO:0000303|Ref.4};
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1] {ECO:0000312|EMBL:AFC87804.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP   DEVELOPMENTAL STAGE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=26078299; DOI=10.1093/jisesa/iev057;
RA   Shi X.F., Li Y.N., Yi Y.Z., Xiao X.G., Zhang Z.F.;
RT   "Identification and Characterization of 30 K Protein Genes Found in Bombyx
RT   mori (Lepidoptera: Bombycidae) Transcriptome.";
RL   J. Insect Sci. 15:71-71(2015).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Tokai X Asahi; TISSUE=Fat body;
RX   PubMed=1883839; DOI=10.1016/0167-4781(91)90048-q;
RA   Mori S., Izumi S., Tomino S.;
RT   "Complete nucleotide sequences of major plasma protein genes of Bombyx
RT   mori.";
RL   Biochim. Biophys. Acta 1090:129-132(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=p50T;
RX   PubMed=15591204; DOI=10.1126/science.1102210;
RA   Xia Q., Zhou Z., Lu C., Cheng D., Dai F., Li B., Zhao P., Zha X., Cheng T.,
RA   Chai C., Pan G., Xu J., Liu C., Lin Y., Qian J., Hou Y., Wu Z., Li G.,
RA   Pan M., Li C., Shen Y., Lan X., Yuan L., Li T., Xu H., Yang G., Wan Y.,
RA   Zhu Y., Yu M., Shen W., Wu D., Xiang Z., Yu J., Wang J., Li R., Shi J.,
RA   Li H., Li G., Su J., Wang X., Li G., Zhang Z., Wu Q., Li J., Zhang Q.,
RA   Wei N., Xu J., Sun H., Dong L., Liu D., Zhao S., Zhao X., Meng Q., Lan F.,
RA   Huang X., Li Y., Fang L., Li C., Li D., Sun Y., Zhang Z., Yang Z.,
RA   Huang Y., Xi Y., Qi Q., He D., Huang H., Zhang X., Wang Z., Li W., Cao Y.,
RA   Yu Y., Yu H., Li J., Ye J., Chen H., Zhou Y., Liu B., Wang J., Ye J.,
RA   Ji H., Li S., Ni P., Zhang J., Zhang Y., Zheng H., Mao B., Wang W., Ye C.,
RA   Li S., Wang J., Wong G.K.-S., Yang H.;
RT   "A draft sequence for the genome of the domesticated silkworm (Bombyx
RT   mori).";
RL   Science 306:1937-1940(2004).
RN   [4] {ECO:0000305}
RP   NOMENCLATURE, AND DEVELOPMENTAL STAGE.
RX   DOI=10.1111/j.1744-7917.2007.00121.x;
RA   Sun Q., Zhao P., Lin Y., Hou Y., Xia Q.-Y., Xiang Z.-H.;
RT   "Analysis of the structure and expression of the 30K protein genes in
RT   silkworm, Bombyx mori.";
RL   Insect Sci. 14:5-14(2007).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26078299}.
CC   -!- TISSUE SPECIFICITY: Detected in larval hemolymph (at protein level).
CC       {ECO:0000269|PubMed:26078299}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in fat body from the fifth larval instar
CC       through to the pupal stage (Ref.4, PubMed:26078299). Highest expression
CC       levels are found at the wandering stage which marks the transition from
CC       larva to pupa (Ref.4). Expression then declines during later pupal
CC       stages (Ref.4). {ECO:0000269|PubMed:26078299, ECO:0000269|Ref.4}.
CC   -!- MISCELLANEOUS: This lipoprotein belongs to the group of structurally
CC       related '30 kDa proteins' that comprise major protein components of the
CC       fifth (and last) instar larvae and of pupae. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the 30 kDa lipoprotein family. {ECO:0000305}.
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DR   EMBL; JN977524; AFC87804.1; -; mRNA.
DR   EMBL; X54734; CAA38531.1; -; Genomic_DNA.
DR   EMBL; BABH01021941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; S17661; S17661.
DR   RefSeq; XP_012550539.1; XM_012695085.1.
DR   AlphaFoldDB; Q00801; -.
DR   SMR; Q00801; -.
DR   STRING; 7091.BGIBMGA004395-TA; -.
DR   EnsemblMetazoa; BGIBMGA004395-RA; BGIBMGA004395-TA; BGIBMGA004395.
DR   GeneID; 778471; -.
DR   CTD; 778471; -.
DR   HOGENOM; CLU_053201_2_0_1; -.
DR   OrthoDB; 1430900at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.10.2400; -; 1.
DR   InterPro; IPR004943; Lipoprotein_11.
DR   InterPro; IPR042046; Lipoprotein_11_N.
DR   Pfam; PF03260; Lipoprotein_11; 1.
PE   1: Evidence at protein level;
KW   Lipoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..263
FT                   /note="Low molecular mass lipoprotein 4"
FT                   /id="PRO_0000021573"
FT   CONFLICT        19
FT                   /note="T -> A (in Ref. 2; CAA38531)"
FT   CONFLICT        24
FT                   /note="G -> V (in Ref. 2; CAA38531)"
FT   CONFLICT        76
FT                   /note="K -> G (in Ref. 2; CAA38531)"
SQ   SEQUENCE   263 AA;  30242 MW;  6789C929AC8DF5DE CRC64;
     MKFLVVFASC VLAVSAGVTE MSAGSMSSSN KELEEKLYNS ILTGDYDSAV RQSLEYENQG
     KGSIIQNVVN NLIIDKSRNT MEYCYKLWVG NGQHIVRKYF PYNFRLIMAG NFVKLIYRNY
     NLALKLGPTL DPANERLAYG DGKEKNSDLI SWKFITLWEN NRVYFKIHNT KYNQYLKLSS
     TTDCNTQDRV IFGTNTADTT REQWFLQPTK YENDVLFFIY NREYNDALKL GRIVDASGDR
     MAFGHDGEVA GLPDIFSWFV TPF