LPA1_ARATH
ID LPA1_ARATH Reviewed; 453 AA.
AC Q9SRY4;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Protein LOW PSII ACCUMULATION 1, chloroplastic;
DE Flags: Precursor;
GN Name=LPA1; OrderedLocusNames=At1g02910; ORFNames=F22D16.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, INTERACTION WITH PSBA; PSBD; PETB AND ALB3, DISRUPTION PHENOTYPE,
RP AND SUBCELLULAR LOCATION.
RX PubMed=16531500; DOI=10.1105/tpc.105.037689;
RA Peng L., Ma J., Chi W., Guo J., Zhu S., Lu Q., Lu C., Zhang L.;
RT "LOW PSII ACCUMULATION1 is involved in efficient assembly of photosystem II
RT in Arabidopsis thaliana.";
RL Plant Cell 18:955-969(2006).
RN [4]
RP RETRACTED PAPER.
RX PubMed=17601825; DOI=10.1105/tpc.107.050526;
RA Ma J., Peng L., Guo J., Lu Q., Lu C., Zhang L.;
RT "LPA2 is required for efficient assembly of photosystem II in Arabidopsis
RT thaliana.";
RL Plant Cell 19:1980-1993(2007).
RN [5]
RP RETRACTION NOTICE OF PUBMED:17601825.
RX PubMed=27895223; DOI=10.1105/tpc.16.00881;
RA Ma J., Peng L., Guo J., Lu Q., Lu C., Zhang L.;
RL Plant Cell 28:3061-3061(2016).
CC -!- FUNCTION: Chaperone required for efficient photosystem II (PSII)
CC assembly. Binds to psbA during de novo biogenesis of PSII.
CC {ECO:0000269|PubMed:16531500}.
CC -!- SUBUNIT: Interacts with psbA, but not with psbD, petB, ALB3, LPA2 or
CC LPA3. Is not a component of the PSII complex.
CC {ECO:0000269|PubMed:16531500}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000269|PubMed:16531500}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16531500}.
CC -!- DISRUPTION PHENOTYPE: Pale-green phenotype and greatly reduced growth.
CC Disturbed thylakoid membrane systems. {ECO:0000269|PubMed:16531500}.
CC -!- MISCELLANEOUS: Accumulates even in dark-grown seedlings.
CC {ECO:0000305|PubMed:16531500}.
CC -!- CAUTION: An article reported a lack of interaction with LPA2; however,
CC this paper was later retracted. {ECO:0000305|PubMed:17601825,
CC ECO:0000305|PubMed:27895223}.
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DR EMBL; AC009525; AAF02875.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27495.1; -; Genomic_DNA.
DR PIR; E86159; E86159.
DR RefSeq; NP_171790.1; NM_100172.3.
DR AlphaFoldDB; Q9SRY4; -.
DR SMR; Q9SRY4; -.
DR BioGRID; 24585; 1.
DR STRING; 3702.AT1G02910.1; -.
DR PaxDb; Q9SRY4; -.
DR PRIDE; Q9SRY4; -.
DR ProteomicsDB; 238796; -.
DR EnsemblPlants; AT1G02910.1; AT1G02910.1; AT1G02910.
DR GeneID; 839350; -.
DR Gramene; AT1G02910.1; AT1G02910.1; AT1G02910.
DR KEGG; ath:AT1G02910; -.
DR Araport; AT1G02910; -.
DR TAIR; locus:2024720; AT1G02910.
DR eggNOG; ENOG502QQWZ; Eukaryota.
DR HOGENOM; CLU_042585_1_0_1; -.
DR InParanoid; Q9SRY4; -.
DR OMA; FDTRAQS; -.
DR OrthoDB; 1179930at2759; -.
DR PhylomeDB; Q9SRY4; -.
DR PRO; PR:Q9SRY4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SRY4; baseline and differential.
DR Genevisible; Q9SRY4; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0010270; P:photosystem II oxygen evolving complex assembly; IMP:TAIR.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR021883; LPA1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF11998; DUF3493; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Chloroplast; Membrane; Plastid; Reference proteome; Repeat; Thylakoid;
KW TPR repeat; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..92
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 93..453
FT /note="Protein LOW PSII ACCUMULATION 1, chloroplastic"
FT /id="PRO_0000425143"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 75..108
FT /note="TPR 1"
FT REPEAT 112..145
FT /note="TPR 2"
SQ SEQUENCE 453 AA; 50739 MW; 8E48AFF237AE57DD CRC64;
MAVATAPSLN RHFPRRISNL YSRVKQRRPW LPPGDATLFN SRRNWDSHLF VYASSSSSPS
SSPPSPNSPT DDLTAELCVN TGLDLFKRGR VKDALVQFET ALSLAPNPIE SQAAYYNKAC
CHAYRGEGKK AVDCLRIALR DYNLKFATIL NDPDLASFRA LPEFKELQEE ARLGGEDIGD
NFRRDLKLIS EVRAPFRGVR KFFYFAFAAA AGISMFFTVP RLVQAIRGGD GAPNLLETTG
NAAINIGGIV VMVSLFLWEN KKEEEQMVQI TRDETLSRLP LRLSTNRVVE LVQLRDTVRP
VILAGKKETV TLAMQKADRF RTELLRRGVL LVPVVWGERK TPEIEKKGFG ASSKAATSLP
SIGEDFDTRA QSVVAQSKLK GEIRFKAETV SPGEWERWIR DQQISEGVNP GDDVYIILRL
DGRVRRSGRG MPDWAEISKE LPPMDDVLSK LER
