LPAH1_ARATH
ID LPAH1_ARATH Reviewed; 738 AA.
AC Q9FJH9;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=P-loop NTPase domain-containing protein LPA1 homolog 1 {ECO:0000305};
DE AltName: Full=Protein LOW PHYTIC ACID 1 homolog 1 {ECO:0000305};
GN OrderedLocusNames=At5g60760 {ECO:0000312|Araport:AT5G60760};
GN ORFNames=MAE1.1 {ECO:0000312|EMBL:BAB10097.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20734061; DOI=10.1007/s00425-010-1243-5;
RA Kim S.I., Tai T.H.;
RT "Genetic analysis of two OsLpa1-like genes in Arabidopsis reveals that only
RT one is required for wild-type seed phytic acid levels.";
RL Planta 232:1241-1250(2010).
CC -!- FUNCTION: Required for the accumulation of phytic acid in seeds. Phytic
CC acid is the primary storage form of phosphorus in cereal grains and
CC other plant seeds. {ECO:0000269|PubMed:20734061}.
CC -!- DISRUPTION PHENOTYPE: Strong reduction in seed phytic acid with a molar
CC equivalent increase in inorganic phosphate.
CC {ECO:0000269|PubMed:20734061}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB015472; BAB10097.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97374.1; -; Genomic_DNA.
DR EMBL; BT002943; AAO22756.1; -; mRNA.
DR EMBL; BT004378; AAO42372.1; -; mRNA.
DR RefSeq; NP_200884.2; NM_125469.3.
DR AlphaFoldDB; Q9FJH9; -.
DR STRING; 3702.AT5G60760.1; -.
DR PaxDb; Q9FJH9; -.
DR PRIDE; Q9FJH9; -.
DR ProteomicsDB; 238483; -.
DR EnsemblPlants; AT5G60760.1; AT5G60760.1; AT5G60760.
DR GeneID; 836197; -.
DR Gramene; AT5G60760.1; AT5G60760.1; AT5G60760.
DR KEGG; ath:AT5G60760; -.
DR Araport; AT5G60760; -.
DR TAIR; locus:2159270; AT5G60760.
DR eggNOG; ENOG502QR37; Eukaryota.
DR HOGENOM; CLU_014708_0_1_1; -.
DR InParanoid; Q9FJH9; -.
DR OMA; QDHEEVG; -.
DR OrthoDB; 1206241at2759; -.
DR PhylomeDB; Q9FJH9; -.
DR PRO; PR:Q9FJH9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FJH9; baseline and differential.
DR Genevisible; Q9FJH9; AT.
DR GO; GO:0010264; P:myo-inositol hexakisphosphate biosynthetic process; IMP:TAIR.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..738
FT /note="P-loop NTPase domain-containing protein LPA1 homolog
FT 1"
FT /id="PRO_0000431862"
FT REGION 245..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..604
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 82541 MW; AFCF82473AD7C742 CRC64;
MTETTKVMYI VVVDGTDTAE TVEEDGTGTW KDSFRYTRPV LQSTLQLMGC KARHAFKISR
RVFELIRSEG SLILSPSLSP SHSKESEFQK TGDASACANV EKANKVNSLA TDDVDKSKSK
PFEVYKRRTT VVVSREIFVN VVCDALAEYK YVGHDQRADL ILSCRIRERK ESVTVLLCGT
SGCGKSTLSA LLGSRLGITT VVSTDSIRHM MRSFVDEKQN PLLWASTYHA GEYLDPVAVA
ESKARRRRAK KMDSIEDEKA KASEGGKAKN TQQTDVGSTK NTPVLLSPKQ MAVEGFKAQS
EMVIDNLDRL ITAWEERKES VIVEGVHLSL NFVMGLMKKH PSIVPFMVYI ANEEKHLERF
AVRAKYMTLD PEKNKYVKYI RNIRTIQDYL CKRADKHLVP KINNTNVDKS VAAIHATVFS
CLRRREAGEH LYDATTNTVS VIDDEYRNQC TANSLSSKGM FQLIQRKGSS RHLMALLNTD
GTFARTWPVT GKVDESGKPV FCNEMIEENG MEHPVYGYLQ KAEPVNLQFG LFGISAWPSD
GATSRAGSVD DCKADMAETS SRYYSSCCSS PRMSEGTSKE LKEDQSVHGS DEEVEDDPPE
PDTDFSDDDN KRDHDEVGSV DEQSTKSDEE YDDLAMEDKS YWTDEEEESR DTIAIMSEKN
NKQATKEDKY IQNLDLFLRT ANQQLVEPLQ LCASLLTCEN GNTRLWLGKE KMRKRSLSIS
AIGKHGSGLG DAILLGAP
