LPAH2_ARATH
ID LPAH2_ARATH Reviewed; 717 AA.
AC Q93ZS1; Q9M1V0;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=P-loop NTPase domain-containing protein LPA1 homolog 2 {ECO:0000305};
DE AltName: Full=Protein LOW PHYTIC ACID 1 homolog 2 {ECO:0000305};
GN OrderedLocusNames=At3g45090 {ECO:0000312|Araport:AT3G45090};
GN ORFNames=T14D3.30 {ECO:0000312|EMBL:CAB72147.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20734061; DOI=10.1007/s00425-010-1243-5;
RA Kim S.I., Tai T.H.;
RT "Genetic analysis of two OsLpa1-like genes in Arabidopsis reveals that only
RT one is required for wild-type seed phytic acid levels.";
RL Planta 232:1241-1250(2010).
CC -!- FUNCTION: May be not required for the accumulation of phytic acid in
CC seeds. Phytic acid is the primary storage form of phosphorus in cereal
CC grains and other plant seeds. {ECO:0000269|PubMed:20734061}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q93ZS1-1; Sequence=Displayed;
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions and normal levels of phytic acid in seeds.
CC {ECO:0000269|PubMed:20734061}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB72147.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL138649; CAB72147.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002686; AEE77991.1; -; Genomic_DNA.
DR EMBL; AY056298; AAL07147.1; -; mRNA.
DR EMBL; AY096678; AAM20312.1; -; mRNA.
DR PIR; T47449; T47449.
DR RefSeq; NP_566873.1; NM_114378.3. [Q93ZS1-1]
DR AlphaFoldDB; Q93ZS1; -.
DR STRING; 3702.AT3G45090.1; -.
DR iPTMnet; Q93ZS1; -.
DR PaxDb; Q93ZS1; -.
DR PRIDE; Q93ZS1; -.
DR ProteomicsDB; 238727; -. [Q93ZS1-1]
DR EnsemblPlants; AT3G45090.1; AT3G45090.1; AT3G45090. [Q93ZS1-1]
DR GeneID; 823644; -.
DR Gramene; AT3G45090.1; AT3G45090.1; AT3G45090. [Q93ZS1-1]
DR KEGG; ath:AT3G45090; -.
DR Araport; AT3G45090; -.
DR TAIR; locus:2096865; AT3G45090.
DR eggNOG; ENOG502QR37; Eukaryota.
DR HOGENOM; CLU_014708_0_1_1; -.
DR InParanoid; Q93ZS1; -.
DR OMA; THCLVAD; -.
DR OrthoDB; 1206241at2759; -.
DR PhylomeDB; Q93ZS1; -.
DR PRO; PR:Q93ZS1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q93ZS1; baseline and differential.
DR Genevisible; Q93ZS1; AT.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..717
FT /note="P-loop NTPase domain-containing protein LPA1 homolog
FT 2"
FT /id="PRO_0000431863"
FT REGION 235..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..580
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..595
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 717 AA; 80249 MW; 5A1206354022B0B4 CRC64;
MMTEATKVLY IVVREEGDDD DNNGDDSFRY TRPVLQSTLQ LMGCKARHAF KISRRVFELI
RSEGSCNTSP ENGKEPEFAK EVGGSTCVEK LNCLVVAGDV DKNKSKPFEM YKRRTTVVVS
REIFVDVVCD ALAEYKYVGR DQRADLILAC RIRERKESVT VLLCGTSGCG KSTLSALLGS
RLGITTVVST DSIRHMMRSF ADEKQNPLLW ASTYHAGEYL DPVAVAESKA KRKAKKLKGS
RGVNSNAQKT DAGSNSSTTE LLSHKQMAIE GYKAQSEMVI DSLDRLITTW EERNESVVVE
GVHLSLNFVM GLMKKHPSIV PFMVYIANEE KHLERFAVRA KYMTLDPAKN KYVKYIRNIR
TIQDYLCKRA DKHLVPKINN TNVDKSVATI HATVFGCLRR RETGEKLYDT TTNTVSVIDD
EHRNQCAANS LTSKGMFQVI QRQGSSRRFM ALCNTDGTVA KTWPVASVGK IRKPVVNTEM
DDGTEHQLHK AEPVNLQFGH FGISAWPSDG ATSHAGSVDD LRADIIETGS RHYSSCCSSP
RTSDGPSKEL MEEQSVNGSD EDDEEGDDDF HEPDSDEDLS DNNDERNRDE IGSVDEESTK
SDEEYDDLAM EDKSYWTDNE EEESRDTISM VSQNNHNEAS KTNKDDKYSQ NLDLFLKTTN
QPLTESLELT SEYRNRMGVA ASDKAKMRKR SLSIPPVGKH GSIIDDQILA NQTDSVL
