LPAR3_HUMAN
ID LPAR3_HUMAN Reviewed; 353 AA.
AC Q9UBY5; A0AVA3;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Lysophosphatidic acid receptor 3;
DE Short=LPA receptor 3;
DE Short=LPA-3;
DE AltName: Full=Lysophosphatidic acid receptor Edg-7;
GN Name=LPAR3; Synonyms=EDG7, LPA3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=T-cell;
RX PubMed=10488122; DOI=10.1074/jbc.274.39.27776;
RA Bandoh K., Aoki J., Hosono H., Kobayashi S., Kobayashi T.,
RA Murakami-Murofushi K., Tsujimoto M., Arai H., Inoue K.;
RT "Molecular cloning and characterization of a novel human G-protein-coupled
RT receptor, EDG7, for lysophosphatidic acid.";
RL J. Biol. Chem. 274:27776-27785(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryonic kidney;
RX PubMed=10727522; DOI=10.1124/mol.57.4.753;
RA Im D.-S., Heise C.E., Harding M.A., George S.R., O'Dowd B.F.,
RA Theodorescu D., Lynch K.R.;
RT "Molecular cloning and characterization of a lysophosphatidic acid
RT receptor, Edg-7, expressed in prostate.";
RL Mol. Pharmacol. 57:753-759(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP REVIEW.
RX PubMed=11093753; DOI=10.1124/mol.58.6.1188;
RA Contos J.J.A., Ishii I., Chun J.;
RT "Lysophosphatidic acid receptors.";
RL Mol. Pharmacol. 58:1188-1196(2000).
CC -!- FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of
CC diverse cellular activities. May play a role in the development of
CC ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families
CC of heteromeric G proteins.
CC -!- INTERACTION:
CC Q9UBY5; Q13520: AQP6; NbExp=3; IntAct=EBI-12033434, EBI-13059134;
CC Q9UBY5; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-12033434, EBI-11343438;
CC Q9UBY5; Q8WWH4: ASZ1; NbExp=3; IntAct=EBI-12033434, EBI-12239061;
CC Q9UBY5; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-12033434, EBI-747430;
CC Q9UBY5; Q6UWD8: C16orf54; NbExp=3; IntAct=EBI-12033434, EBI-18041102;
CC Q9UBY5; P19397: CD53; NbExp=3; IntAct=EBI-12033434, EBI-6657396;
CC Q9UBY5; P04233-2: CD74; NbExp=4; IntAct=EBI-12033434, EBI-12222807;
CC Q9UBY5; P11912: CD79A; NbExp=3; IntAct=EBI-12033434, EBI-7797864;
CC Q9UBY5; P57739: CLDN2; NbExp=3; IntAct=EBI-12033434, EBI-751440;
CC Q9UBY5; O95471: CLDN7; NbExp=3; IntAct=EBI-12033434, EBI-740744;
CC Q9UBY5; O95484: CLDN9; NbExp=3; IntAct=EBI-12033434, EBI-18341636;
CC Q9UBY5; Q2HXU8-2: CLEC12B; NbExp=3; IntAct=EBI-12033434, EBI-12811991;
CC Q9UBY5; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-12033434, EBI-18013275;
CC Q9UBY5; Q96BA8: CREB3L1; NbExp=5; IntAct=EBI-12033434, EBI-6942903;
CC Q9UBY5; P49447: CYB561; NbExp=3; IntAct=EBI-12033434, EBI-8646596;
CC Q9UBY5; Q53TN4: CYBRD1; NbExp=3; IntAct=EBI-12033434, EBI-8637742;
CC Q9UBY5; Q92838: EDA; NbExp=3; IntAct=EBI-12033434, EBI-529425;
CC Q9UBY5; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-12033434, EBI-781551;
CC Q9UBY5; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12033434, EBI-18304435;
CC Q9UBY5; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-12033434, EBI-18938272;
CC Q9UBY5; O15552: FFAR2; NbExp=3; IntAct=EBI-12033434, EBI-2833872;
CC Q9UBY5; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-12033434, EBI-12142257;
CC Q9UBY5; O95377: GJB5; NbExp=3; IntAct=EBI-12033434, EBI-3909454;
CC Q9UBY5; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-12033434, EBI-3917143;
CC Q9UBY5; Q8TED1: GPX8; NbExp=3; IntAct=EBI-12033434, EBI-11721746;
CC Q9UBY5; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-12033434, EBI-10266796;
CC Q9UBY5; P48547: KCNC1; NbExp=3; IntAct=EBI-12033434, EBI-12830942;
CC Q9UBY5; P48051: KCNJ6; NbExp=3; IntAct=EBI-12033434, EBI-12017638;
CC Q9UBY5; O95214: LEPROTL1; NbExp=3; IntAct=EBI-12033434, EBI-750776;
CC Q9UBY5; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-12033434, EBI-2820517;
CC Q9UBY5; Q9H400: LIME1; NbExp=3; IntAct=EBI-12033434, EBI-2830566;
CC Q9UBY5; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-12033434, EBI-11956541;
CC Q9UBY5; O14880: MGST3; NbExp=3; IntAct=EBI-12033434, EBI-724754;
CC Q9UBY5; Q6IN84: MRM1; NbExp=3; IntAct=EBI-12033434, EBI-5454865;
CC Q9UBY5; Q96JQ5: MS4A4A; NbExp=3; IntAct=EBI-12033434, EBI-12820341;
CC Q9UBY5; Q8N183: NDUFAF2; NbExp=3; IntAct=EBI-12033434, EBI-2682365;
CC Q9UBY5; P35372-10: OPRM1; NbExp=3; IntAct=EBI-12033434, EBI-12807478;
CC Q9UBY5; O15173: PGRMC2; NbExp=3; IntAct=EBI-12033434, EBI-1050125;
CC Q9UBY5; Q8NC24: RELL2; NbExp=3; IntAct=EBI-12033434, EBI-10269209;
CC Q9UBY5; Q86VR2: RETREG3; NbExp=5; IntAct=EBI-12033434, EBI-10192441;
CC Q9UBY5; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-12033434, EBI-17247926;
CC Q9UBY5; Q8NHU3: SGMS2; NbExp=3; IntAct=EBI-12033434, EBI-10977284;
CC Q9UBY5; Q3SXP7: SHISAL1; NbExp=3; IntAct=EBI-12033434, EBI-18037857;
CC Q9UBY5; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-12033434, EBI-18159983;
CC Q9UBY5; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-12033434, EBI-17295964;
CC Q9UBY5; O14948-3: TFEC; NbExp=3; IntAct=EBI-12033434, EBI-12246506;
CC Q9UBY5; Q8WY91: THAP4; NbExp=3; IntAct=EBI-12033434, EBI-726691;
CC Q9UBY5; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12033434, EBI-8638294;
CC Q9UBY5; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12033434, EBI-10982110;
CC Q9UBY5; Q96HV5: TMEM41A; NbExp=3; IntAct=EBI-12033434, EBI-10288884;
CC Q9UBY5; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-12033434, EBI-18178701;
CC Q9UBY5; Q9BUB7: TMEM70; NbExp=3; IntAct=EBI-12033434, EBI-726363;
CC Q9UBY5; Q9BSE2: TMEM79; NbExp=3; IntAct=EBI-12033434, EBI-8649725;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Most abundantly expressed in prostate, testes,
CC pancreas, and heart, with moderate levels in lung and ovary. No
CC detectable expression in brain, placenta, liver, skeletal muscle,
CC kidney, spleen, thymus, small intestine, colon, or peripheral blood
CC leukocytes.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF127138; AAD56311.1; -; mRNA.
DR EMBL; AF186380; AAF00530.1; -; mRNA.
DR EMBL; AY322547; AAP84360.1; -; mRNA.
DR EMBL; BC126268; AAI26269.1; -; mRNA.
DR EMBL; BC126270; AAI26271.1; -; mRNA.
DR CCDS; CCDS700.1; -.
DR RefSeq; NP_036284.1; NM_012152.2.
DR AlphaFoldDB; Q9UBY5; -.
DR SMR; Q9UBY5; -.
DR BioGRID; 117108; 98.
DR IntAct; Q9UBY5; 53.
DR STRING; 9606.ENSP00000395389; -.
DR BindingDB; Q9UBY5; -.
DR ChEMBL; CHEMBL3250; -.
DR GuidetoPHARMACOLOGY; 274; -.
DR SwissLipids; SLP:000001572; -.
DR GlyGen; Q9UBY5; 2 sites.
DR iPTMnet; Q9UBY5; -.
DR PhosphoSitePlus; Q9UBY5; -.
DR BioMuta; LPAR3; -.
DR DMDM; 26393418; -.
DR MassIVE; Q9UBY5; -.
DR PaxDb; Q9UBY5; -.
DR PeptideAtlas; Q9UBY5; -.
DR PRIDE; Q9UBY5; -.
DR ProteomicsDB; 84099; -.
DR Antibodypedia; 2955; 339 antibodies from 35 providers.
DR DNASU; 23566; -.
DR Ensembl; ENST00000370611.4; ENSP00000359643.3; ENSG00000171517.6.
DR Ensembl; ENST00000440886.1; ENSP00000395389.1; ENSG00000171517.6.
DR GeneID; 23566; -.
DR KEGG; hsa:23566; -.
DR MANE-Select; ENST00000370611.4; ENSP00000359643.3; NM_012152.3; NP_036284.1.
DR UCSC; uc001dkl.3; human.
DR CTD; 23566; -.
DR DisGeNET; 23566; -.
DR GeneCards; LPAR3; -.
DR HGNC; HGNC:14298; LPAR3.
DR HPA; ENSG00000171517; Tissue enhanced (fallopian).
DR MIM; 605106; gene.
DR neXtProt; NX_Q9UBY5; -.
DR OpenTargets; ENSG00000171517; -.
DR PharmGKB; PA162394213; -.
DR VEuPathDB; HostDB:ENSG00000171517; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244941; -.
DR HOGENOM; CLU_047979_0_0_1; -.
DR InParanoid; Q9UBY5; -.
DR OMA; MKRMICC; -.
DR OrthoDB; 1366218at2759; -.
DR PhylomeDB; Q9UBY5; -.
DR TreeFam; TF330052; -.
DR PathwayCommons; Q9UBY5; -.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-419408; Lysosphingolipid and LPA receptors.
DR SignaLink; Q9UBY5; -.
DR SIGNOR; Q9UBY5; -.
DR BioGRID-ORCS; 23566; 9 hits in 1068 CRISPR screens.
DR ChiTaRS; LPAR3; human.
DR GeneWiki; LPAR3; -.
DR GenomeRNAi; 23566; -.
DR Pharos; Q9UBY5; Tchem.
DR PRO; PR:Q9UBY5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9UBY5; protein.
DR Bgee; ENSG00000171517; Expressed in bronchial epithelial cell and 134 other tissues.
DR Genevisible; Q9UBY5; HS.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; TAS:ProtInc.
DR GO; GO:0070915; F:lysophosphatidic acid receptor activity; IEA:InterPro.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0032060; P:bleb assembly; IEA:Ensembl.
DR GO; GO:0007268; P:chemical synaptic transmission; TAS:ProtInc.
DR GO; GO:0048668; P:collateral sprouting; IEA:Ensembl.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0048672; P:positive regulation of collateral sprouting; IEA:Ensembl.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0019222; P:regulation of metabolic process; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004065; LPA_rcpt.
DR InterPro; IPR005385; LPA_rcpt_EDG7.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01560; EDG7RECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01527; LPARECEPTOR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Lipoprotein;
KW Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..353
FT /note="Lysophosphatidic acid receptor 3"
FT /id="PRO_0000069433"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..186
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..353
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 309
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 15
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 231
FT /note="R -> Q (in dbSNP:rs35745543)"
FT /id="VAR_049415"
SQ SEQUENCE 353 AA; 40128 MW; 105DC9DD185E2CE7 CRC64;
MNECHYDKHM DFFYNRSNTD TVDDWTGTKL VIVLCVGTFF CLFIFFSNSL VIAAVIKNRK
FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN RWFLRQGLLD SSLTASLTNL
LVIAVERHMS IMRMRVHSNL TKKRVTLLIL LVWAIAIFMG AVPTLGWNCL CNISACSSLA
PIYSRSYLVF WTVSNLMAFL IMVVVYLRIY VYVKRKTNVL SPHTSGSISR RRTPMKLMKT
VMTVLGAFVV CWTPGLVVLL LDGLNCRQCG VQHVKRWFLL LALLNSVVNP IIYSYKDEDM
YGTMKKMICC FSQENPERRP SRIPSTVLSR SDTGSQYIED SISQGAVCNK STS
