LPAR5_BOVIN
ID LPAR5_BOVIN Reviewed; 367 AA.
AC Q3ZC80;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Lysophosphatidic acid receptor 5;
DE Short=LPA receptor 5;
DE Short=LPA-5;
DE AltName: Full=G-protein coupled receptor 92;
GN Name=LPAR5; Synonyms=GPR92;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of
CC diverse cellular activities. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BC102849; AAI02850.1; -; mRNA.
DR RefSeq; NP_001029476.1; NM_001034304.2.
DR RefSeq; XP_005207181.1; XM_005207124.3.
DR RefSeq; XP_010803875.1; XM_010805573.2.
DR RefSeq; XP_010803876.1; XM_010805574.2.
DR AlphaFoldDB; Q3ZC80; -.
DR SMR; Q3ZC80; -.
DR STRING; 9913.ENSBTAP00000005968; -.
DR PaxDb; Q3ZC80; -.
DR Ensembl; ENSBTAT00000005968; ENSBTAP00000005968; ENSBTAG00000004541.
DR GeneID; 507598; -.
DR KEGG; bta:507598; -.
DR CTD; 57121; -.
DR VEuPathDB; HostDB:ENSBTAG00000004541; -.
DR VGNC; VGNC:30959; LPAR5.
DR eggNOG; ENOG502QUH0; Eukaryota.
DR GeneTree; ENSGT00950000183136; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q3ZC80; -.
DR OMA; SCLFLMC; -.
DR OrthoDB; 1169914at2759; -.
DR TreeFam; TF350009; -.
DR Reactome; R-BTA-416476; G alpha (q) signalling events.
DR Reactome; R-BTA-418594; G alpha (i) signalling events.
DR Reactome; R-BTA-419408; Lysosphingolipid and LPA receptors.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000004541; Expressed in esophagus and 83 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0048266; P:behavioral response to pain; IBA:GO_Central.
DR GO; GO:0032793; P:positive regulation of CREB transcription factor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..367
FT /note="Lysophosphatidic acid receptor 5"
FT /id="PRO_0000245015"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..95
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..186
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..367
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 332..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 93..174
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 367 AA; 40639 MW; E4DC172C392170AA CRC64;
MQANSSAKSL PTECPDYQPI HHLHLVVYSV VLAAGLPLNA LALWVFLRAL RVHSVVSVYM
CNLAASDLLF TLSLPLRLSY YARHYWPFPD FLCQLAGAVF QMNMYGSCIF LTLINVDRYA
AIVHPLRLRH LRRPRVARLL CLGVWALILV FAVPTILAHQ PSSCARDGRN VSLCFESFSD
KLWKGSLLPL LLLAEALGFL LPLAAVVYSS GRVFWTLARP DATRSQRRRK TVRLLLASLV
IFLLCFVPYN ATLAVYGLLR GEVVPASSEA RKKVRGVLMV MVLLAGANCV LDPLVYYFSA
EGFRNTLRGL RAPLRDRTLA ANGAQEALAE PLTETAHAST LTTTSQGQLQ PSDPRSSFTP
SHEDSSF
