LPAR5_HUMAN
ID LPAR5_HUMAN Reviewed; 372 AA.
AC Q9H1C0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Lysophosphatidic acid receptor 5;
DE Short=LPA receptor 5;
DE Short=LPA-5;
DE AltName: Full=G-protein coupled receptor 92;
DE AltName: Full=G-protein coupled receptor 93;
GN Name=LPAR5; Synonyms=GPR92, GPR93;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11062477; DOI=10.1038/81664;
RA White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J.,
RA Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M.;
RT "Autosomal dominant hypophosphataemic rickets is associated with mutations
RT in FGF23.";
RL Nat. Genet. 26:345-348(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11574155; DOI=10.1016/s0378-1119(01)00651-5;
RA Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O.,
RA Lewis T., Evans J.F., George S.R., O'Dowd B.F.;
RT "Discovery and mapping of ten novel G protein-coupled receptor genes.";
RL Gene 275:83-91(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=B-cell, and Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of
CC diverse cellular activities.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Not expressed in frontal cortex, basal forebrain,
CC caudate putamen, thalamus, or hippocampus.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AJ272207; CAC03715.1; -; mRNA.
DR EMBL; AF411112; AAL26483.1; -; Genomic_DNA.
DR EMBL; AB083600; BAB89313.1; -; Genomic_DNA.
DR EMBL; BC033571; AAH33571.1; -; mRNA.
DR EMBL; BC072394; AAH72394.1; -; mRNA.
DR CCDS; CCDS8553.1; -.
DR RefSeq; NP_001136433.1; NM_001142961.1.
DR RefSeq; NP_065133.1; NM_020400.5.
DR AlphaFoldDB; Q9H1C0; -.
DR SMR; Q9H1C0; -.
DR BioGRID; 121385; 2.
DR STRING; 9606.ENSP00000327875; -.
DR BindingDB; Q9H1C0; -.
DR ChEMBL; CHEMBL5700; -.
DR GuidetoPHARMACOLOGY; 124; -.
DR SwissLipids; SLP:000001578; -.
DR GlyGen; Q9H1C0; 2 sites.
DR iPTMnet; Q9H1C0; -.
DR PhosphoSitePlus; Q9H1C0; -.
DR BioMuta; LPAR5; -.
DR DMDM; 48474954; -.
DR jPOST; Q9H1C0; -.
DR MassIVE; Q9H1C0; -.
DR PaxDb; Q9H1C0; -.
DR PeptideAtlas; Q9H1C0; -.
DR PRIDE; Q9H1C0; -.
DR ProteomicsDB; 80396; -.
DR Antibodypedia; 2962; 206 antibodies from 30 providers.
DR DNASU; 57121; -.
DR Ensembl; ENST00000329858.9; ENSP00000327875.4; ENSG00000184574.10.
DR Ensembl; ENST00000431922.1; ENSP00000393098.1; ENSG00000184574.10.
DR GeneID; 57121; -.
DR KEGG; hsa:57121; -.
DR MANE-Select; ENST00000329858.9; ENSP00000327875.4; NM_020400.6; NP_065133.1.
DR UCSC; uc001qps.3; human.
DR CTD; 57121; -.
DR DisGeNET; 57121; -.
DR GeneCards; LPAR5; -.
DR HGNC; HGNC:13307; LPAR5.
DR HPA; ENSG00000184574; Tissue enhanced (esophagus).
DR MIM; 606926; gene.
DR neXtProt; NX_Q9H1C0; -.
DR OpenTargets; ENSG00000184574; -.
DR PharmGKB; PA28935; -.
DR VEuPathDB; HostDB:ENSG00000184574; -.
DR eggNOG; ENOG502QUH0; Eukaryota.
DR GeneTree; ENSGT00950000183136; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q9H1C0; -.
DR OMA; SCLFLMC; -.
DR OrthoDB; 1169914at2759; -.
DR PhylomeDB; Q9H1C0; -.
DR TreeFam; TF350009; -.
DR PathwayCommons; Q9H1C0; -.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-419408; Lysosphingolipid and LPA receptors.
DR SignaLink; Q9H1C0; -.
DR SIGNOR; Q9H1C0; -.
DR BioGRID-ORCS; 57121; 14 hits in 1084 CRISPR screens.
DR ChiTaRS; LPAR5; human.
DR GeneWiki; LPAR5; -.
DR GenomeRNAi; 57121; -.
DR Pharos; Q9H1C0; Tchem.
DR PRO; PR:Q9H1C0; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9H1C0; protein.
DR Bgee; ENSG00000184574; Expressed in gingival epithelium and 160 other tissues.
DR ExpressionAtlas; Q9H1C0; baseline and differential.
DR Genevisible; Q9H1C0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0048266; P:behavioral response to pain; IBA:GO_Central.
DR GO; GO:0032793; P:positive regulation of CREB transcription factor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..372
FT /note="Lysophosphatidic acid receptor 5"
FT /id="PRO_0000069600"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 312..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 94..175
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 372 AA; 41347 MW; BA35709084BB6D84 CRC64;
MLANSSSTNS SVLPCPDYRP THRLHLVVYS LVLAAGLPLN ALALWVFLRA LRVHSVVSVY
MCNLAASDLL FTLSLPVRLS YYALHHWPFP DLLCQTTGAI FQMNMYGSCI FLMLINVDRY
AAIVHPLRLR HLRRPRVARL LCLGVWALIL VFAVPAARVH RPSRCRYRDL EVRLCFESFS
DELWKGRLLP LVLLAEALGF LLPLAAVVYS SGRVFWTLAR PDATQSQRRR KTVRLLLANL
VIFLLCFVPY NSTLAVYGLL RSKLVAASVP ARDRVRGVLM VMVLLAGANC VLDPLVYYFS
AEGFRNTLRG LGTPHRARTS ATNGTRAALA QSERSAVTTD ATRPDAASQG LLRPSDSHSL
SSFTQCPQDS AL
