LPAR6_CHICK
ID LPAR6_CHICK Reviewed; 308 AA.
AC P32250;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Lysophosphatidic acid receptor 6;
DE Short=LPA receptor 6;
DE Short=LPA-6;
DE AltName: Full=Oleoyl-L-alpha-lysophosphatidic acid receptor;
DE AltName: Full=P2Y purinoceptor 5;
DE Short=P2Y5;
DE AltName: Full=Purinergic receptor 5;
GN Name=LPAR6; Synonyms=P2RY5;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=T-cell;
RX PubMed=8393036;
RA Kaplan M.H., Smith D.I., Sundick R.S.;
RT "Identification of a G protein coupled receptor induced in activated T
RT cells.";
RL J. Immunol. 151:628-636(1993).
RN [2]
RP CHARACTERIZATION.
RX PubMed=8619790; DOI=10.1006/bbrc.1996.0189;
RA Webb T.E., Kaplan M.G., Barnard E.A.;
RT "Identification of 6H1 as a P2Y purinoceptor: P2Y5.";
RL Biochem. Biophys. Res. Commun. 219:105-110(1996).
CC -!- FUNCTION: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA).
CC Intracellular cAMP is involved in the receptor activation (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Induced in activated T-cells.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; L06109; AAB06587.1; -; mRNA.
DR PIR; I50241; I50241.
DR AlphaFoldDB; P32250; -.
DR SMR; P32250; -.
DR VEuPathDB; HostDB:geneid_396118; -.
DR InParanoid; P32250; -.
DR PhylomeDB; P32250; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0070915; F:lysophosphatidic acid receptor activity; IBA:GO_Central.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IBA:GO_Central.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..308
FT /note="Lysophosphatidic acid receptor 6"
FT /id="PRO_0000070027"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..89
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..109
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..178
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..206
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 281
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 86..165
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 308 AA; 35597 MW; 4214E969633B6F7D CRC64;
MVSSNCSTED SFKYTLYGCV FSMVFVLGLI ANCVAIYIFT FTLKVRNETT TYMLNLAISD
LLFVFTLPFR IYYFVVRNWP FGDVLCKISV TLFYTNMYGS ILFLTCISVD RFLAIVHPFR
SKTLRTKRNA RIVCVAVWIT VLAGSTPASF FQSTNRQNNT EQRTCFENFP ESTWKTYLSR
IVIFIEIVGF FIPLILNVTC STMVLRTLNK PLTLSRNKLS KKKVLKMIFV HLVIFCFCFV
PYNITLILYS LMRTQTWINC SVVTAVRTMY PVTLCIAVSN CCFDPIVYYF TSDTNSELDK
KQQVHQNT
