LPAR6_HUMAN
ID LPAR6_HUMAN Reviewed; 344 AA.
AC P43657; A4FTW9; B3KVF2; F2YGU4; O15133; Q3KPF5; Q53FA0; Q5VW44; Q7Z3S0;
AC Q7Z3S6;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2003, sequence version 3.
DT 03-AUG-2022, entry version 182.
DE RecName: Full=Lysophosphatidic acid receptor 6;
DE Short=LPA receptor 6;
DE Short=LPA-6;
DE AltName: Full=Oleoyl-L-alpha-lysophosphatidic acid receptor;
DE AltName: Full=P2Y purinoceptor 5;
DE Short=P2Y5;
DE AltName: Full=Purinergic receptor 5;
DE AltName: Full=RB intron encoded G-protein coupled receptor;
GN Name=LPAR6; Synonyms=P2RY5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7902321; DOI=10.1006/geno.1993.1368;
RA Toguchida J., McGee T.L., Paterson J.C., Eagle J.R., Tucker S.,
RA Yandell D.W., Dryja T.P.;
RT "Complete genomic sequence of the human retinoblastoma susceptibility
RT gene.";
RL Genomics 17:535-543(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8889552; DOI=10.1101/gr.6.9.858;
RA Herzog H., Darby K., Hort Y.J., Shine J.;
RT "Intron 17 of the human retinoblastoma susceptibility gene encodes an
RT actively transcribed G protein-coupled receptor gene.";
RL Genome Res. 6:858-861(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Bohm S.K., Trumpp A., Khitin L.M., Kong W., Payan D.G., Bunnett N.W.;
RT "The human purinergic receptor P2Y5 is encoded in intron 17 of the
RT retinoblastoma gene.";
RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Endometrium, and Heart;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Subthalamic nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Peripheral blood leukocyte;
RA Kaighin V.A., Martin A.L., Aronstam R.S.;
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT TRP-137.
RG NIEHS SNPs program;
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Placenta, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [12]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=11004484; DOI=10.1016/s0167-4781(00)00094-4;
RA Adrian K., Bernhard M.K., Breitinger H.-G., Ogilvie A.;
RT "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic
RT P2Y1-11) during myeloid differentiation of HL60 cells.";
RL Biochim. Biophys. Acta 1492:127-138(2000).
RN [13]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INVOLVEMENT IN
RP HYPT8.
RX PubMed=18297070; DOI=10.1038/ng.84;
RA Pasternack S.M., von Kuegelgen I., Aboud K.A., Lee Y.-A., Rueschendorf F.,
RA Voss K., Hillmer A.M., Molderings G.J., Franz T., Ramirez A., Nuernberg P.,
RA Noethen M.M., Betz R.C.;
RT "G protein-coupled receptor P2Y5 and its ligand LPA are involved in
RT maintenance of human hair growth.";
RL Nat. Genet. 40:329-334(2008).
RN [14]
RP VARIANTS ARWH1 VAL-63; PHE-188 AND LYS-189, AND TISSUE SPECIFICITY.
RX PubMed=18297072; DOI=10.1038/ng.100;
RA Shimomura Y., Wajid M., Ishii Y., Shapiro L., Petukhova L., Gordon D.,
RA Christiano A.M.;
RT "Disruption of P2RY5, an orphan G protein-coupled receptor, underlies
RT autosomal recessive woolly hair.";
RL Nat. Genet. 40:335-339(2008).
CC -!- FUNCTION: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA).
CC Intracellular cAMP is involved in the receptor activation. Important
CC for the maintenance of hair growth and texture.
CC {ECO:0000269|PubMed:18297070}.
CC -!- INTERACTION:
CC P43657; P54849: EMP1; NbExp=3; IntAct=EBI-2876949, EBI-4319440;
CC P43657; Q9NS64: RPRM; NbExp=3; IntAct=EBI-2876949, EBI-1052363;
CC P43657; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-2876949, EBI-8652744;
CC P43657; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-2876949, EBI-741850;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18297070};
CC Multi-pass membrane protein {ECO:0000269|PubMed:18297070}.
CC -!- TISSUE SPECIFICITY: Expressed ubiquitously, including in skin and hair
CC follicle cells. Detected in both Henle's and Huxley's layers of the
CC inner root sheath of the hair follicle and in suprabasal layers of the
CC epidermis (at protein level). Expressed at low levels in peripheral
CC blood leukocytes. {ECO:0000269|PubMed:11004484,
CC ECO:0000269|PubMed:18297070, ECO:0000269|PubMed:18297072}.
CC -!- DEVELOPMENTAL STAGE: Markedly up-regulated in promyelocytic HL60 cells
CC induced to differentiate along the monocyte/macrophage pathway. Not
CC detectable in undifferentiated HL60 cells and only low levels after the
CC induction of differentiation along the granulocytic pathway.
CC {ECO:0000269|PubMed:11004484}.
CC -!- DISEASE: Woolly hair autosomal recessive 1 with or without
CC hypotrichosis (ARWH1) [MIM:278150]: A hair shaft disorder characterized
CC by fine and tightly curled hair. Compared to normal curly hair that is
CC observed in some populations, woolly hair grows slowly and stops
CC growing after a few inches. Under light microscopy, woolly hair shows
CC some structural anomalies, including trichorrhexis nodosa and tapered
CC ends. Some individuals exhibit features of hypotrichosis.
CC {ECO:0000269|PubMed:18297072}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Hypotrichosis 8 (HYPT8) [MIM:278150]: A condition
CC characterized by the presence of less than the normal amount of hair
CC and abnormal hair follicles and shafts, which are thin and atrophic.
CC The disorder affects the trunk and extremities as well as the scalp,
CC and the eyebrows and eyelashes may also be involved, whereas beard,
CC pubic, and axillary hairs are largely spared. In addition, patients can
CC develop hyperkeratotic follicular papules, erythema, and pruritus in
CC affected areas. In some patients with congenital hypotrichosis,
CC monilethrix-like hairs showing elliptical nodes have been observed.
CC HYPT8 inheritance is autosomal recessive.
CC {ECO:0000269|PubMed:18297070}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- MISCELLANEOUS: This is a nested gene within intron 17 of the
CC retinoblastoma gene.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=L11910; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; L11910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; L78805; AAL40065.1; -; Genomic_DNA.
DR EMBL; AF000546; AAB62190.1; -; mRNA.
DR EMBL; BX537392; CAD97634.1; -; mRNA.
DR EMBL; BX537438; CAD97680.1; -; mRNA.
DR EMBL; BX537445; CAD97687.1; -; mRNA.
DR EMBL; AK122856; BAG53764.1; -; mRNA.
DR EMBL; AK223389; BAD97109.1; -; mRNA.
DR EMBL; HQ995530; ADZ31975.1; -; mRNA.
DR EMBL; JF810890; AEP43757.1; -; mRNA.
DR EMBL; AF551763; AAN64134.1; -; Genomic_DNA.
DR EMBL; AL392048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08796.1; -; Genomic_DNA.
DR EMBL; BC040850; AAH40850.1; -; mRNA.
DR EMBL; BC045651; AAH45651.1; -; mRNA.
DR EMBL; BC070295; AAH70295.1; -; mRNA.
DR EMBL; BC106756; AAI06757.1; -; mRNA.
DR CCDS; CCDS9410.1; -.
DR PIR; T09508; T09508.
DR RefSeq; NP_001155969.1; NM_001162497.1.
DR RefSeq; NP_001155970.1; NM_001162498.1.
DR RefSeq; NP_005758.2; NM_005767.5.
DR AlphaFoldDB; P43657; -.
DR SMR; P43657; -.
DR BioGRID; 115463; 66.
DR IntAct; P43657; 36.
DR MINT; P43657; -.
DR STRING; 9606.ENSP00000367691; -.
DR BindingDB; P43657; -.
DR ChEMBL; CHEMBL2331058; -.
DR DrugBank; DB01069; Promethazine.
DR GuidetoPHARMACOLOGY; 163; -.
DR SwissLipids; SLP:000001579; -.
DR GlyGen; P43657; 1 site.
DR iPTMnet; P43657; -.
DR PhosphoSitePlus; P43657; -.
DR BioMuta; LPAR6; -.
DR DMDM; 34223726; -.
DR MassIVE; P43657; -.
DR PaxDb; P43657; -.
DR PeptideAtlas; P43657; -.
DR PRIDE; P43657; -.
DR ProteomicsDB; 55648; -.
DR Antibodypedia; 9381; 150 antibodies from 28 providers.
DR DNASU; 10161; -.
DR Ensembl; ENST00000345941.2; ENSP00000344353.2; ENSG00000139679.16.
DR Ensembl; ENST00000378434.8; ENSP00000367691.3; ENSG00000139679.16.
DR Ensembl; ENST00000620633.5; ENSP00000482660.1; ENSG00000139679.16.
DR GeneID; 10161; -.
DR KEGG; hsa:10161; -.
DR MANE-Select; ENST00000620633.5; ENSP00000482660.1; NM_001162498.3; NP_001155970.1.
DR UCSC; uc001vce.4; human.
DR CTD; 10161; -.
DR DisGeNET; 10161; -.
DR GeneCards; LPAR6; -.
DR HGNC; HGNC:15520; LPAR6.
DR HPA; ENSG00000139679; Low tissue specificity.
DR MalaCards; LPAR6; -.
DR MIM; 278150; phenotype.
DR MIM; 609239; gene.
DR neXtProt; NX_P43657; -.
DR OpenTargets; ENSG00000139679; -.
DR Orphanet; 55654; Hypotrichosis simplex.
DR Orphanet; 170; Woolly hair.
DR PharmGKB; PA165505129; -.
DR VEuPathDB; HostDB:ENSG00000139679; -.
DR eggNOG; ENOG502QSC2; Eukaryota.
DR GeneTree; ENSGT01040000240444; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; P43657; -.
DR OMA; NMYGSML; -.
DR OrthoDB; 323029at2759; -.
DR PhylomeDB; P43657; -.
DR TreeFam; TF350009; -.
DR PathwayCommons; P43657; -.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-417957; P2Y receptors.
DR SignaLink; P43657; -.
DR SIGNOR; P43657; -.
DR BioGRID-ORCS; 10161; 11 hits in 1034 CRISPR screens.
DR ChiTaRS; LPAR6; human.
DR GenomeRNAi; 10161; -.
DR Pharos; P43657; Tchem.
DR PRO; PR:P43657; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; P43657; protein.
DR Bgee; ENSG00000139679; Expressed in gingival epithelium and 179 other tissues.
DR ExpressionAtlas; P43657; baseline and differential.
DR Genevisible; P43657; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0070915; F:lysophosphatidic acid receptor activity; IBA:GO_Central.
DR GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IBA:GO_Central.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disease variant; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Hypotrichosis; Lipoprotein; Membrane; Palmitate; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..344
FT /note="Lysophosphatidic acid receptor 6"
FT /id="PRO_0000070025"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..92
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..112
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..253
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 284
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 89..168
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 33
FT /note="I -> V (in dbSNP:rs1060585)"
FT /id="VAR_022636"
FT VARIANT 63
FT /note="D -> V (in ARWH1; dbSNP:rs879255262)"
FT /evidence="ECO:0000269|PubMed:18297072"
FT /id="VAR_044326"
FT VARIANT 137
FT /note="C -> W (in dbSNP:rs4151553)"
FT /evidence="ECO:0000269|Ref.8"
FT /id="VAR_016253"
FT VARIANT 188
FT /note="I -> F (in ARWH1; dbSNP:rs121434307)"
FT /evidence="ECO:0000269|PubMed:18297072"
FT /id="VAR_044327"
FT VARIANT 189
FT /note="E -> K (in ARWH1; dbSNP:rs121434309)"
FT /evidence="ECO:0000269|PubMed:18297072"
FT /id="VAR_044328"
FT VARIANT 307
FT /note="W -> C (in dbSNP:rs17071686)"
FT /id="VAR_049430"
FT CONFLICT 242
FT /note="F -> I (in Ref. 6; BAD97109)"
FT /evidence="ECO:0000305"
FT CONFLICT 303
FT /note="K -> I (in Ref. 4; CAD97680)"
FT /evidence="ECO:0000305"
FT CONFLICT 344
FT /note="A -> G (in Ref. 4; CAD97687)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 344 AA; 39392 MW; 699212F3C1249433 CRC64;
MVSVNSSHCF YNDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICVLKVRN ETTTYMINLA
MSDLLFVFTL PFRIFYFTTR NWPFGDLLCK ISVMLFYTNM YGSILFLTCI SVDRFLAIVY
PFKSKTLRTK RNAKIVCTGV WLTVIGGSAP AVFVQSTHSQ GNNASEACFE NFPEATWKTY
LSRIVIFIEI VGFFIPLILN VTCSSMVLKT LTKPVTLSRS KINKTKVLKM IFVHLIIFCF
CFVPYNINLI LYSLVRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN
SIKMKNWSVR RSDFRFSEVH GAENFIQHNL QTLKSKIFDN ESAA