LPAR6_RAT
ID LPAR6_RAT Reviewed; 344 AA.
AC Q4G072;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Lysophosphatidic acid receptor 6;
DE Short=LPA receptor 6;
DE Short=LPA-6;
DE AltName: Full=Oleoyl-L-alpha-lysophosphatidic acid receptor;
DE AltName: Full=P2Y purinoceptor 5;
DE Short=P2Y5;
DE AltName: Full=Purinergic receptor 5;
GN Name=Lpar6; Synonyms=P2ry5, P2y5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA).
CC Intracellular cAMP is involved in the receptor activation. Important
CC for the maintenance of hair growth and texture (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BC098703; AAH98703.1; -; mRNA.
DR RefSeq; NP_001039308.1; NM_001045843.1.
DR AlphaFoldDB; Q4G072; -.
DR SMR; Q4G072; -.
DR STRING; 10116.ENSRNOP00000021430; -.
DR GlyGen; Q4G072; 1 site.
DR PhosphoSitePlus; Q4G072; -.
DR PaxDb; Q4G072; -.
DR Ensembl; ENSRNOT00000021430; ENSRNOP00000021430; ENSRNOG00000015577.
DR GeneID; 691774; -.
DR KEGG; rno:691774; -.
DR UCSC; RGD:1595950; rat.
DR CTD; 10161; -.
DR RGD; 1595950; Lpar6.
DR eggNOG; ENOG502QSC2; Eukaryota.
DR GeneTree; ENSGT01040000240444; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q4G072; -.
DR OMA; NMYGSML; -.
DR OrthoDB; 840755at2759; -.
DR PhylomeDB; Q4G072; -.
DR TreeFam; TF350009; -.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR Reactome; R-RNO-417957; P2Y receptors.
DR PRO; PR:Q4G072; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Bgee; ENSRNOG00000015577; Expressed in thymus and 19 other tissues.
DR Genevisible; Q4G072; RN.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0070915; F:lysophosphatidic acid receptor activity; IBA:GO_Central.
DR GO; GO:0001835; P:blastocyst hatching; ISO:RGD.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IBA:GO_Central.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..344
FT /note="Lysophosphatidic acid receptor 6"
FT /id="PRO_0000342665"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..230
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 89..168
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 344 AA; 39330 MW; AE959337B5C36ACD CRC64;
MVSANGSHCP YDDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICALKVRN ETTTYMINLA
MSDLLFVFTL PFRIFYFATR NWPFGDLLCK ISVMLFYTNM YGSILFLTCI SVDRFLAIVY
PFKSKTLRTK RNAKIVCIAV WFTVMGGSAP AVFFQSTHSQ GNNTSEACFE NFPAATWKTY
LSRIVIFIEI VGFFIPLILN VTCSSMVLRT LNKPVTLSRS KMNKTKVLKM IFVHLVIFCF
CFVPYNINLI LYSLVRTQTF VNCSVGAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN
SIKMKSWSVR RSDSRFSEVQ GTENFIQHNL QTLKNKIFDN ESAI
