ID   LPB1_NEIMB              Reviewed;         419 AA.
AC   Q05014;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Capsule polysaccharide modification protein LipB;
GN   Name=lipB; OrderedLocusNames=NMB0083;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=B1940 / Serogroup B;
RX   PubMed=8326861; DOI=10.1111/j.1365-2958.1993.tb01592.x;
RA   Frosch M., Mueller A.;
RT   "Phospholipid substitution of capsular polysaccharides and mechanisms of
RT   capsule formation in Neisseria meningitidis.";
RL   Mol. Microbiol. 8:483-493(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- FUNCTION: Involved in the phospholipid modification of the capsular
CC       polysaccharide, a strong requirement for its translocation to the cell
CC       surface.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
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DR   EMBL; Z13995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AE002098; AAF40547.1; -; Genomic_DNA.
DR   PIR; E81240; E81240.
DR   RefSeq; NP_273146.1; NC_003112.2.
DR   RefSeq; WP_002223278.1; NC_003112.2.
DR   AlphaFoldDB; Q05014; -.
DR   SMR; Q05014; -.
DR   STRING; 122586.NMB0083; -.
DR   PaxDb; Q05014; -.
DR   EnsemblBacteria; AAF40547; AAF40547; NMB0083.
DR   GeneID; 61282322; -.
DR   KEGG; nme:NMB0083; -.
DR   PATRIC; fig|122586.8.peg.118; -.
DR   HOGENOM; CLU_040135_1_0_4; -.
DR   OMA; WVFEEGY; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0015774; P:polysaccharide transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007833; Capsule_polysaccharide_synth.
DR   Pfam; PF05159; Capsule_synth; 1.
PE   4: Predicted;
KW   Cell inner membrane; Cell membrane; Membrane; Polysaccharide transport;
KW   Reference proteome; Sugar transport; Transport.
FT   CHAIN           1..419
FT                   /note="Capsule polysaccharide modification protein LipB"
FT                   /id="PRO_0000084464"
FT   CONFLICT        410
FT                   /note="K -> N (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        413
FT                   /note="N -> D (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        418..419
FT                   /note="VI -> TT (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   419 AA;  48702 MW;  096A5E05CB5D8283 CRC64;
     MKQTVLKNNL QNLLESAENI LLLQGPVGDF FLRLADWLTA NGKTVHKFNF NAGDDYFYPP
     TQAHTVVFND NYDAFPEFLQ EYITQHHIQA VVCFGDTRPY HVIAKRIANE NQASFWAFEE
     GYFRPYYITL EKDGVNAFSP LPRRADFFLE QFPKLAQQEY KAPTPVHGGF TPMAKNAIRY
     YIELFRNPRK YPDYIHHRAP NAGHYLKPWS LSILKRLNYY IEDIQIAKRV EAGKYGKFFI
     VPLQVFNDSQ VRIHCDFPSV RSFLLHVLSS FAEHAPADTN IIIKHHPMDR GFIDYWRDIK
     RFIKEHPELK GRVIYVHDVP LPVFLRHGLG MVTINSTSGL SGLIHNMPVK VLGRAYYDIP
     GITDQNTLAE FWNHPTPPDK ELFHAYRMYH LNVTQINGNF YSQVFFPNKK TSNSSTPVI