ID   LPE10_ASHGO             Reviewed;         393 AA.
AC   Q75A69;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter LPE10;
DE   Flags: Precursor;
GN   Name=LPE10; OrderedLocusNames=ADR049W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO N-TERMINUS.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Mitochondrial inner membrane magnesium transporter required
CC       for mitochondrial magnesium homeostasis. Modulates the conductance of
CC       the MRS2 channel. Involved in the splicing of mRNA group II introns in
CC       mitochondria by affecting mitochondrial magnesium concentrations, which
CC       are critical for group II intron splicing.
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SUBUNIT: Forms homooligomers. Interacts with MRS2.
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q02783}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS51969.2; -; Genomic_DNA.
DR   RefSeq; NP_984145.2; NM_209498.2.
DR   AlphaFoldDB; Q75A69; -.
DR   SMR; Q75A69; -.
DR   STRING; 33169.AAS51969; -.
DR   EnsemblFungi; AAS51969; AAS51969; AGOS_ADR049W.
DR   GeneID; 4620294; -.
DR   KEGG; ago:AGOS_ADR049W; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   HOGENOM; CLU_025144_1_0_1; -.
DR   InParanoid; Q75A69; -.
DR   OMA; TRNNCII; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; IBA:GO_Central.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
PE   3: Inferred from homology;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..45
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           46..393
FT                   /note="Mitochondrial inner membrane magnesium transporter
FT                   LPE10"
FT                   /id="PRO_0000042815"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           340..343
FT                   /note="YGMN"
SQ   SEQUENCE   393 AA;  44054 MW;  BA5864B7BA40652A CRC64;
     MLGLRLPVCR RAVMASPRAC WRLWHSSTAA AAGMQDLSAV LQRNLALRNQ SLYNQSSDTI
     RCSMFDSDGA LIGGAAADIR REELIQKHGL LPRDLRKIEM ARRHDLVPIV LVRDRCIMVS
     LLTIRALVKS DTVLLFDPMG IGMDSVAHTR FVADLQTRLK NQGAPGLGKD PLPYEFRALE
     SIFITALANL TAELRVHLAV TKGALHDLEY GIDKDKLKFL LVQNKKLSVF HKKSLLMREM
     MDDLMDQDDV LSEMYLSEKM RGKPRDVADH SELEMVLETY YTQVNEIVQS IEGAIANVRT
     TEEIINIILD SNRNELMLLG LRFAIGLLSL GSVMFVAALY GMNLENFIEE GNVGFALVTA
     TGLVLMVCLF RYSIKRLHKL QKMTLLGGQG RHS