ID   LPE10_CANGA             Reviewed;         397 AA.
AC   Q6FJD1;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter LPE10;
DE   Flags: Precursor;
GN   Name=LPE10; OrderedLocusNames=CAGL0M07249g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mitochondrial inner membrane magnesium transporter required
CC       for mitochondrial magnesium homeostasis. Modulates the conductance of
CC       the MRS2 channel. Involved in the splicing of mRNA group II introns in
CC       mitochondria by affecting mitochondrial magnesium concentrations, which
CC       are critical for group II intron splicing.
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SUBUNIT: Forms homooligomers. Interacts with MRS2.
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q02783}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62639.1; -; Genomic_DNA.
DR   RefSeq; XP_449663.1; XM_449663.1.
DR   AlphaFoldDB; Q6FJD1; -.
DR   SMR; Q6FJD1; -.
DR   STRING; 5478.XP_449663.1; -.
DR   EnsemblFungi; CAG62639; CAG62639; CAGL0M07249g.
DR   GeneID; 2891712; -.
DR   KEGG; cgr:CAGL0M07249g; -.
DR   CGD; CAL0136217; CAGL0M07249g.
DR   VEuPathDB; FungiDB:CAGL0M07249g; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   HOGENOM; CLU_025144_1_0_1; -.
DR   InParanoid; Q6FJD1; -.
DR   OMA; TRNNCII; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; IEA:EnsemblFungi.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
DR   Pfam; PF01544; CorA; 1.
PE   3: Inferred from homology;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..37
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           38..397
FT                   /note="Mitochondrial inner membrane magnesium transporter
FT                   LPE10"
FT                   /id="PRO_0000043237"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           340..343
FT                   /note="YGMN"
SQ   SEQUENCE   397 AA;  45159 MW;  06940662E0AE8098 CRC64;
     MLLVNRAITL NLVKRCCWRS TMFMTPKRFL GTSEEESTAA LLLQKNLIQR NNMLYGHGSG
     TIRCTVFDAG GNIVSPALDI KREELVAKHG LLPRDLRKIE KSRKNDLVPS FLVRKNGILV
     SLATIKTLIK PDMVIVFDSF GSLNSTSHKA FLNSLKLRLQ NLDMVELKKD PLPYEFRALE
     SIFISALSNL TSEMNVQVTI CKGILQDLEY SITRDKLKFL LGQNKKLSNF YKKTVLIRDM
     LDDLLEQSDV LCSMYLSDLK NGVEHKDDDH SEIEMLLETY HNHLDEIVQI TENIISNVKT
     TEEIINIILD SNRNQLMLLG IRFSIGMLSL GGPIFIGSLY GMNLENFIEE TDYGFIAASA
     IGMISLGALY FYSIKHLHKL QKMSLFNYTN YARDVKK