ID   LPE10_KLULA             Reviewed;         397 AA.
AC   Q6CIB3;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter LPE10;
DE   Flags: Precursor;
GN   Name=LPE10; OrderedLocusNames=KLLA0F28017g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mitochondrial inner membrane magnesium transporter required
CC       for mitochondrial magnesium homeostasis. Modulates the conductance of
CC       the MRS2 channel. Involved in the splicing of mRNA group II introns in
CC       mitochondria by affecting mitochondrial magnesium concentrations, which
CC       are critical for group II intron splicing.
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SUBUNIT: Forms homooligomers. Interacts with MRS2.
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q02783}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG99034.1; -; Genomic_DNA.
DR   RefSeq; XP_456326.1; XM_456326.1.
DR   AlphaFoldDB; Q6CIB3; -.
DR   SMR; Q6CIB3; -.
DR   STRING; 28985.XP_456326.1; -.
DR   EnsemblFungi; CAG99034; CAG99034; KLLA0_F28017g.
DR   GeneID; 2895051; -.
DR   KEGG; kla:KLLA0_F28017g; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   HOGENOM; CLU_025144_1_0_1; -.
DR   InParanoid; Q6CIB3; -.
DR   OMA; TRNNCII; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; IEA:EnsemblFungi.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
PE   3: Inferred from homology;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..48
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           49..397
FT                   /note="Mitochondrial inner membrane magnesium transporter
FT                   LPE10"
FT                   /id="PRO_0000043238"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           342..345
FT                   /note="YGMN"
SQ   SEQUENCE   397 AA;  45452 MW;  5B2EE093230FF858 CRC64;
     MLFIRQLSVI PKAPAFAKFF HTAGLVRQKL SDPNHLAILL QKNLAQRNSS LYNPELETIR
     CTIFDRHGNM QKPSIDLRRD ELIHTHGLLP RDLRKVEKSR RNDLVPSVLV RENSILVSIL
     NIRALVKSDM LILFDSMGIK LDSVSQQNFI ADLQLRLQNR SGFEVPDVVN KDPLPYEFRA
     VESIFISAIS NLNAELKVHL NVSTGILQDL EYSITRDKLR YLLIQNKKLS VFHKKSFLMR
     EMIEELLEQD DVLCEMYLTE KQLGKPREEH DHAEIEMLLE TYYNHVDEIV QTVGNTMSNI
     KTTEEIINII LDSNRNQLML LGLRFSIGLL SLAGSIFIAS IYGMNLENFI EEGNVGFPVV
     STLGVILMAY LFAFSVKHLH KLEKVQLMSH GKSSTLK