ID   LPE10_YARLI             Reviewed;         455 AA.
AC   Q6C8H7;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter LPE10;
DE   Flags: Precursor;
GN   Name=LPE10; OrderedLocusNames=YALI0D19514g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mitochondrial inner membrane magnesium transporter required
CC       for mitochondrial magnesium homeostasis. Modulates the conductance of
CC       the MRS2 channel. Involved in the splicing of mRNA group II introns in
CC       mitochondria by affecting mitochondrial magnesium concentrations, which
CC       are critical for group II intron splicing.
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SUBUNIT: Forms homooligomers. Interacts with MRS2.
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q02783}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; CR382130; CAG81227.1; -; Genomic_DNA.
DR   RefSeq; XP_503035.1; XM_503035.1.
DR   AlphaFoldDB; Q6C8H7; -.
DR   SMR; Q6C8H7; -.
DR   STRING; 4952.CAG81227; -.
DR   EnsemblFungi; CAG81227; CAG81227; YALI0_D19514g.
DR   GeneID; 2911169; -.
DR   KEGG; yli:YALI0D19514g; -.
DR   VEuPathDB; FungiDB:YALI0_D19514g; -.
DR   HOGENOM; CLU_025144_1_3_1; -.
DR   InParanoid; Q6C8H7; -.
DR   OMA; TRNNCII; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
DR   Pfam; PF01544; CorA; 1.
PE   3: Inferred from homology;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..56
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           57..455
FT                   /note="Mitochondrial inner membrane magnesium transporter
FT                   LPE10"
FT                   /id="PRO_0000043249"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          433..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           382..385
FT                   /note="YGMN"
SQ   SEQUENCE   455 AA;  51127 MW;  49878E3D4F9BDCEE CRC64;
     MHIKISTDFA IQNLHCTTMI RPLLRLCGQR TAATPFVSFF RPPKKPLSGI SFARHYSPTK
     KPPSEVPTPT PGNYLVPITG PPGDTPRDTD LLIKSLTHKS LLPENNLVRC TVFDSDGNVT
     VASGEFKRTE LLNKHGLLPR DLRKLDTGVN SIVPTILVRD NSILINLLHI RALIKADKVL
     LFDVFGSTDS KTQSLFMYDL GHKLKKSNKT MGSLPYEMRA LEAIFISVIA ALDAEMKVHT
     TVINGILSEL EQDIDREKLR HLLIQSKKLS AFLQKATLIR DVIDELLDTD EDLAGLYLTE
     KKAGHPRAID DHSEVEMLLE TYYKHCDEIV QTVGNLVSNI RNTEEIVNII LDANRNALMH
     LDLKFQIGAL GLAGGTFIAS LYGMNLKNFI EESYWGFLGV TGVASLLTVW IIAHFLKSLR
     QVQRVTMTSD KKKAMKKKDT VAEKRRNHLR NWLTK