ID   LPFA_ECO57              Reviewed;         178 AA.
AC   Q8X5K5; Q7A9Y5;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2013, sequence version 3.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Probable major fimbrial subunit LpfA;
DE   Flags: Precursor;
GN   Name=lpfA; OrderedLocusNames=Z4971, ECs4431;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [3]
RP   FUNCTION, INDUCTION, AND GENE NAME.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=12228266; DOI=10.1128/iai.70.10.5416-5427.2002;
RA   Torres A.G., Giron J.A., Perna N.T., Burland V., Blattner F.R.,
RA   Avelino-Flores F., Kaper J.B.;
RT   "Identification and characterization of lpfABCC'DE, a fimbrial operon of
RT   enterohemorrhagic Escherichia coli O157:H7.";
RL   Infect. Immun. 70:5416-5427(2002).
CC   -!- FUNCTION: Part of the lpfABCC'DE fimbrial operon. LP fimbriae may
CC       participate in the interaction with eukaryotic cells by assisting in
CC       microcolony formation. {ECO:0000269|PubMed:12228266}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC   -!- INDUCTION: Induced during the exponential growth phase.
CC       {ECO:0000269|PubMed:12228266}.
CC   -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG58695.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37854.1; -; Genomic_DNA.
DR   PIR; C86029; C86029.
DR   PIR; G91182; G91182.
DR   RefSeq; NP_312458.1; NC_002695.1.
DR   AlphaFoldDB; Q8X5K5; -.
DR   SMR; Q8X5K5; -.
DR   STRING; 155864.EDL933_4811; -.
DR   EnsemblBacteria; AAG58695; AAG58695; Z4971.
DR   EnsemblBacteria; BAB37854; BAB37854; ECs_4431.
DR   GeneID; 915703; -.
DR   KEGG; ece:Z4971; -.
DR   KEGG; ecs:ECs_4431; -.
DR   PATRIC; fig|386585.9.peg.4638; -.
DR   eggNOG; COG3539; Bacteria.
DR   HOGENOM; CLU_088965_0_0_6; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.1090; -; 1.
DR   InterPro; IPR000259; Adhesion_dom_fimbrial.
DR   InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   Pfam; PF00419; Fimbrial; 1.
DR   SUPFAM; SSF49401; SSF49401; 1.
PE   2: Evidence at transcript level;
KW   Fimbrium; Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..178
FT                   /note="Probable major fimbrial subunit LpfA"
FT                   /id="PRO_0000429482"
SQ   SEQUENCE   178 AA;  18524 MW;  4E3EDD43593F825E CRC64;
     MEFFMKKVVF ALTALALTSG TVFAAESGDG TVKFTGEIVD SPCVLSVDSQ NQEVVLGQVQ
     KSVFAAVGDK SPAKPFEIKL EDCDTTTMKK ANVSFSGVGD ADKSDLISVS TEAGAAKGVG
     IGIYDNSNTL VALNGGKASV DLSKGQTVLY FTANYVSTLA TVTTGYGNAQ VDFNLSYE