ID   LPFC2_ECO57             Reviewed;         485 AA.
AC   Q8X5K8; Q7A9Y8;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Probable outer membrane usher protein LpfC';
GN   Name=lpfC'; OrderedLocusNames=Z4967, ECs4428;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [3]
RP   FUNCTION, INDUCTION, AND GENE NAME.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=12228266; DOI=10.1128/iai.70.10.5416-5427.2002;
RA   Torres A.G., Giron J.A., Perna N.T., Burland V., Blattner F.R.,
RA   Avelino-Flores F., Kaper J.B.;
RT   "Identification and characterization of lpfABCC'DE, a fimbrial operon of
RT   enterohemorrhagic Escherichia coli O157:H7.";
RL   Infect. Immun. 70:5416-5427(2002).
CC   -!- FUNCTION: Part of the lpfABCC'DE fimbrial operon. LP fimbriae may
CC       participate in the interaction with eukaryotic cells by assisting in
CC       microcolony formation. Could be involved in the export and assembly of
CC       the fimbrial subunits across the outer membrane.
CC       {ECO:0000269|PubMed:12228266}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- INDUCTION: Induced during the exponential growth phase.
CC       {ECO:0000269|PubMed:12228266}.
CC   -!- SIMILARITY: Belongs to the fimbrial export usher family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG58692.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37851.1; -; Genomic_DNA.
DR   PIR; D91182; D91182.
DR   PIR; H86028; H86028.
DR   RefSeq; WP_001121261.1; NZ_CP031913.1.
DR   AlphaFoldDB; Q8X5K8; -.
DR   SMR; Q8X5K8; -.
DR   STRING; 386585.gene:10367507; -.
DR   EnsemblBacteria; AAG58692; AAG58692; Z4967.
DR   KEGG; ece:Z4967; -.
DR   HOGENOM; CLU_009120_3_2_6; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015473; F:fimbrial usher porin activity; IEA:InterPro.
DR   GO; GO:0009297; P:pilus assembly; IEA:InterPro.
DR   Gene3D; 2.60.40.2070; -; 1.
DR   Gene3D; 2.60.40.2610; -; 1.
DR   InterPro; IPR000015; Fimb_usher.
DR   InterPro; IPR042186; FimD_plug_dom.
DR   InterPro; IPR025949; PapC-like_C.
DR   InterPro; IPR043142; PapC-like_C_sf.
DR   PANTHER; PTHR30451; PTHR30451; 1.
DR   Pfam; PF13953; PapC_C; 1.
DR   Pfam; PF00577; Usher; 1.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Fimbrium biogenesis; Membrane; Reference proteome;
KW   Transmembrane; Transport.
FT   CHAIN           1..485
FT                   /note="Probable outer membrane usher protein LpfC'"
FT                   /id="PRO_0000429486"
SQ   SEQUENCE   485 AA;  53236 MW;  0090709B44D0FF8E CRC64;
     MPIFQREGHL KYSFAAGEYQ AGNYDSASPR FGQLDLIYGL PWGMTAYGGV LISNNYNAFT
     LGIGKNFGYI GAISIDVTQA KSELNNDRDS QGQSYRFLYS KSFESGTDFR LAGYRYSTSG
     FYTFQEATDV RSDADSDYNR YHKRSEIQGN LTQQLGAYGS VYLNLTQQDY WNDAGKQNTV
     SAGYNGRIGK VSYSIAYSWN KSPEWDESDR LWSFNISVPL GRAWSNYRVT TDQDGRTNQQ
     VGVSGTLLED RNLSYSVQEG YASNGVGNSG NANVGYQGGS GNVNVGYSYG KDYRQLNYSV
     RGGVIVHSEG VTLSQPLGET MTLISVPGAR NARVVNNGGV QVDWMGNAIV PYAMPYRENE
     ISLRSDSLGD DVDVENAFQK VVPTRGAIVR ARFDTRVGYR VLMTLLRSAG SPVPFGATAT
     LITDKQNEVS SIVGEEGQLY ISGMPEEGRV LIKWGNDASQ QCVAPYKLSL ELKQGGIIPV
     SANCQ