ID   LPFC_ECO57              Reviewed;         367 AA.
AC   Q8X5K7; Q7A9Y7;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Probable outer membrane usher protein LpfC;
DE   Flags: Precursor;
GN   Name=lpfC; OrderedLocusNames=Z4968, ECs4429;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [3]
RP   FUNCTION, INDUCTION, AND GENE NAME.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=12228266; DOI=10.1128/iai.70.10.5416-5427.2002;
RA   Torres A.G., Giron J.A., Perna N.T., Burland V., Blattner F.R.,
RA   Avelino-Flores F., Kaper J.B.;
RT   "Identification and characterization of lpfABCC'DE, a fimbrial operon of
RT   enterohemorrhagic Escherichia coli O157:H7.";
RL   Infect. Immun. 70:5416-5427(2002).
CC   -!- FUNCTION: Part of the lpfABCC'DE fimbrial operon. LP fimbriae may
CC       participate in the interaction with eukaryotic cells by assisting in
CC       microcolony formation. Could be involved in the export and assembly of
CC       the fimbrial subunits across the outer membrane.
CC       {ECO:0000269|PubMed:12228266}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- INDUCTION: Induced during the exponential growth phase.
CC       {ECO:0000269|PubMed:12228266}.
CC   -!- SIMILARITY: Belongs to the fimbrial export usher family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005174; AAG58693.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37852.1; -; Genomic_DNA.
DR   PIR; A86029; A86029.
DR   PIR; E91182; E91182.
DR   RefSeq; WP_000088425.1; NZ_CP031913.1.
DR   AlphaFoldDB; Q8X5K7; -.
DR   SMR; Q8X5K7; -.
DR   STRING; 386585.gene:10367508; -.
DR   EnsemblBacteria; AAG58693; AAG58693; Z4968.
DR   KEGG; ece:Z4968; -.
DR   HOGENOM; CLU_009120_0_0_6; -.
DR   OMA; TRIRDCK; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015473; F:fimbrial usher porin activity; IEA:InterPro.
DR   GO; GO:0009297; P:pilus assembly; IEA:InterPro.
DR   Gene3D; 3.10.20.410; -; 1.
DR   InterPro; IPR000015; Fimb_usher.
DR   InterPro; IPR018030; Fimbrial_membr_usher_CS.
DR   InterPro; IPR025885; PapC_N.
DR   InterPro; IPR037224; PapC_N_sf.
DR   PANTHER; PTHR30451; PTHR30451; 1.
DR   Pfam; PF13954; PapC_N; 1.
DR   Pfam; PF00577; Usher; 1.
DR   SUPFAM; SSF141729; SSF141729; 1.
DR   PROSITE; PS01151; FIMBRIAL_USHER; 1.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Fimbrium biogenesis; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transport.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..367
FT                   /note="Probable outer membrane usher protein LpfC"
FT                   /id="PRO_0000429485"
SQ   SEQUENCE   367 AA;  40298 MW;  5920620A701FE095 CRC64;
     MSRKTVSRTF SSFSISVVAV AVASTFSAHA GKFNPKFLED VQGVGQHVDL TMFEKGQEQQ
     LPGIYRVSVY VNEQRMETRT LEFKEATEAQ RKAMGESLVP CLSRTQLAEM GVRVESFPAL
     NLVSAEACVP FDEIIPLASS HFDFSEQKLV LSFPQAAMHQ VARGTVPESL WDEGIPALLL
     DYSFSGSNSE YDSTGSSSSY VDDNGTVHHD DGKDTLKSDS YYLNLRSGLN LGAWRLRNYS
     TWSHSGGKAQ WDNIGTSLSR AIIPFKAQLT MGDTATAGDI FDSVQMRGAM LASDEEMLPD
     SQRGFAPIVR GIAKSNAEVS IEQNGYVIYR TYVQPGAFEI NDLYPTANSG DLTVIIKEAD
     GSEQRFI