ID   LPHI_ECO57              Reviewed;          16 AA.
AC   Q8X8T5;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=his operon leader peptide;
DE   AltName: Full=his operon attenuator peptide;
GN   Name=hisL; OrderedLocusNames=Z3180, ECs2819;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: This protein is involved in the attenuation mechanism for the
CC       control of the expression of the his operon structural genes.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HisL family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG57077.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36242.1; -; Genomic_DNA.
DR   PIR; A85827; A85827.
DR   PIR; C90981; C90981.
DR   RefSeq; WP_010904803.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8X8T5; -.
DR   EnsemblBacteria; AAG57077; AAG57077; Z3180.
DR   EnsemblBacteria; BAB36242; BAB36242; ECs_2819.
DR   KEGG; ece:Z3180; -.
DR   HOGENOM; CLU_222361_0_0_6; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR012565; His_leader.
DR   Pfam; PF08047; His_leader; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Leader peptide;
KW   Reference proteome.
FT   PEPTIDE         1..16
FT                   /note="his operon leader peptide"
FT                   /id="PRO_0000043987"
SQ   SEQUENCE   16 AA;  2072 MW;  D78A907BF6283BBA CRC64;
     MTRVQFKQHH HHHHPD