ID   LPHI_ECOL6              Reviewed;          16 AA.
AC   P60996; P03058;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=his operon leader peptide;
DE   AltName: Full=his operon attenuator peptide;
GN   Name=hisL; OrderedLocusNames=c5496;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: This protein is involved in the attenuation mechanism for the
CC       control of the expression of the his operon structural genes.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HisL family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN81000.1; -; Genomic_DNA.
DR   RefSeq; WP_001364200.1; NC_004431.1.
DR   AlphaFoldDB; P60996; -.
DR   EnsemblBacteria; AAN81000; AAN81000; c5496.
DR   GeneID; 67461511; -.
DR   KEGG; ecc:c5496; -.
DR   HOGENOM; CLU_222361_0_0_6; -.
DR   BioCyc; ECOL199310:C5496-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR012565; His_leader.
DR   Pfam; PF08047; His_leader; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Leader peptide.
FT   PEPTIDE         1..16
FT                   /note="his operon leader peptide"
FT                   /id="PRO_0000043988"
SQ   SEQUENCE   16 AA;  2081 MW;  C8B7907BF6283BBA CRC64;
     MTRVQFKHHH HHHHPD