LPHI_ECOLI
ID LPHI_ECOLI Reviewed; 16 AA.
AC P60995; P03058; Q2MAY6;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=his operon leader peptide;
DE AltName: Full=his operon attenuator peptide;
GN Name=hisL; OrderedLocusNames=b2018, JW2000;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=360215; DOI=10.1073/pnas.75.9.4276;
RA Dinocera P.P., Blasi F., Dilauro R., Frunzio R., Bruni C.B.;
RT "Nucleotide sequence of the attenuator region of the histidine operon of
RT Escherichia coli K-12.";
RL Proc. Natl. Acad. Sci. U.S.A. 75:4276-4280(1978).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=6170941; DOI=10.1093/nar/9.9.2075;
RA Verde P., Frunzio R., di Nocera P.P., Blasi F., Bruni C.B.;
RT "Identification, nucleotide sequence and expression of the regulatory
RT region of the histidine operon of Escherichia coli K-12.";
RL Nucleic Acids Res. 9:2075-2086(1981).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=3062174; DOI=10.1016/0022-2836(88)90194-5;
RA Carlomagno M.S., Chiariotti L., Alifano P., Nappo A.G., Bruni C.B.;
RT "Structure and function of the Salmonella typhimurium and Escherichia coli
RT K-12 histidine operons.";
RL J. Mol. Biol. 203:585-606(1988).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- FUNCTION: This protein is involved in the attenuation mechanism for the
CC control of the expression of the his operon structural genes.
CC -!- SIMILARITY: Belongs to the HisL family. {ECO:0000305}.
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DR EMBL; V00285; CAA23550.1; -; Genomic_DNA.
DR EMBL; V00284; CAA23548.1; -; Genomic_DNA.
DR EMBL; X13462; CAA31810.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75079.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76570.1; -; Genomic_DNA.
DR PIR; A03594; LFECH.
DR RefSeq; NP_416522.1; NC_000913.3.
DR RefSeq; WP_001364200.1; NZ_STEB01000048.1.
DR AlphaFoldDB; P60995; -.
DR PaxDb; P60995; -.
DR EnsemblBacteria; AAC75079; AAC75079; b2018.
DR EnsemblBacteria; BAE76570; BAE76570; BAE76570.
DR GeneID; 67461511; -.
DR GeneID; 946547; -.
DR KEGG; ecj:JW2000; -.
DR KEGG; eco:b2018; -.
DR EchoBASE; EB1248; -.
DR HOGENOM; CLU_222361_0_0_6; -.
DR BioCyc; EcoCyc:EG11269-MON; -.
DR PRO; PR:P60995; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR012565; His_leader.
DR Pfam; PF08047; His_leader; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Histidine biosynthesis; Leader peptide;
KW Reference proteome.
FT PEPTIDE 1..16
FT /note="his operon leader peptide"
FT /id="PRO_0000043986"
SQ SEQUENCE 16 AA; 2081 MW; C8B7907BF6283BBA CRC64;
MTRVQFKHHH HHHHPD
