LPHN_DROME
ID LPHN_DROME Reviewed; 1697 AA.
AC A1Z7G7; B7YZT6; Q6GKZ7; Q8T3I8;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Latrophilin Cirl {ECO:0000303|PubMed:10798391, ECO:0000312|EMBL:AAF59067.3};
GN Name=Cirl {ECO:0000312|EMBL:AAF59067.3, ECO:0000312|FlyBase:FBgn0033313};
GN ORFNames=CG8639;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF59067.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAF59067.3};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF59067.3}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAT47768.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAT47768.1}; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAM11425.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1238-1697 (ISOFORMS B/C).
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAM11425.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=10798391; DOI=10.1016/s0896-6273(00)81136-8;
RA Lloyd T.E., Verstreken P., Ostrin E.J., Phillippi A., Lichtarge O.,
RA Bellen H.J.;
RT "A genome-wide search for synaptic vesicle cycle proteins in Drosophila.";
RL Neuron 26:45-50(2000).
RN [6] {ECO:0000305}
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1142; SER-1239; SER-1246;
RP SER-1315 AND SER-1316, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo {ECO:0000269|PubMed:18327897};
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
RN [7] {ECO:0000305}
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-242 AND ASN-641, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-linked
RT cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
CC -!- SUBUNIT: Forms a heterodimer, consisting of a large extracellular
CC region non-covalently linked to a seven-transmembrane moiety.
CC {ECO:0000250|UniProtKB:O88923}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000250|UniProtKB:O88923, ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=C {ECO:0000269|PubMed:10731132};
CC IsoId=A1Z7G7-1; Sequence=Displayed;
CC Name=B {ECO:0000269|PubMed:10731132};
CC IsoId=A1Z7G7-2; Sequence=VSP_038966;
CC -!- PTM: Proteolytically cleaved into 2 subunits, an extracellular subunit
CC and a seven-transmembrane subunit. {ECO:0000250|UniProtKB:O88923}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7
CC subfamily. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM11425.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAT47768.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE013599; AAF59067.3; -; Genomic_DNA.
DR EMBL; AE013599; ACL83074.1; -; Genomic_DNA.
DR EMBL; BT014917; AAT47768.1; ALT_INIT; mRNA.
DR EMBL; AY095097; AAM11425.1; ALT_INIT; mRNA.
DR RefSeq; NP_001137620.1; NM_001144148.4. [A1Z7G7-2]
DR RefSeq; NP_001246205.1; NM_001259276.2. [A1Z7G7-2]
DR RefSeq; NP_610397.4; NM_136553.5.
DR AlphaFoldDB; A1Z7G7; -.
DR SMR; A1Z7G7; -.
DR IntAct; A1Z7G7; 1.
DR STRING; 7227.FBpp0302596; -.
DR MEROPS; P02.A01; -.
DR GlyGen; A1Z7G7; 8 sites.
DR iPTMnet; A1Z7G7; -.
DR PaxDb; A1Z7G7; -.
DR PRIDE; A1Z7G7; -.
DR EnsemblMetazoa; FBtr0290112; FBpp0288551; FBgn0033313. [A1Z7G7-2]
DR EnsemblMetazoa; FBtr0305082; FBpp0293619; FBgn0033313. [A1Z7G7-2]
DR EnsemblMetazoa; FBtr0310448; FBpp0302596; FBgn0033313.
DR GeneID; 35846; -.
DR KEGG; dme:Dmel_CG8639; -.
DR UCSC; CG8639-RB; d. melanogaster.
DR CTD; 35846; -.
DR FlyBase; FBgn0033313; Cirl.
DR VEuPathDB; VectorBase:FBgn0033313; -.
DR eggNOG; KOG4193; Eukaryota.
DR eggNOG; KOG4729; Eukaryota.
DR GeneTree; ENSGT00940000173774; -.
DR InParanoid; A1Z7G7; -.
DR PhylomeDB; A1Z7G7; -.
DR Reactome; R-DME-373080; Class B/2 (Secretin family receptors).
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 35846; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Cirl; fly.
DR GenomeRNAi; 35846; -.
DR PRO; PR:A1Z7G7; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033313; Expressed in saliva-secreting gland and 27 other tissues.
DR ExpressionAtlas; A1Z7G7; baseline and differential.
DR Genevisible; A1Z7G7; DM.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0016524; F:latrotoxin receptor activity; ISS:FlyBase.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0008344; P:adult locomotory behavior; IMP:FlyBase.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:FlyBase.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; -; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR SMART; SM00303; GPS; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; G-protein coupled receptor;
KW Glycoprotein; Lectin; Membrane; Phosphoprotein; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..1697
FT /note="Latrophilin Cirl"
FT /id="PRO_0000393375"
FT TOPO_DOM 1..753
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 754..774
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 775..787
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 788..808
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 809..814
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 815..835
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 836..861
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 862..882
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 883..906
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 907..927
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 928..954
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 955..975
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 976..985
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 986..1006
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1007..1697
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 11..100
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00260"
FT DOMAIN 692..739
FT /note="GPS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT REGION 162..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1300..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1438..1526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1551..1570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1605..1677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1300..1318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1477..1492
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1514
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1626..1658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1142
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1239
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1246
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1315
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1316
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 242
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973"
FT CARBOHYD 288
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 327
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 384
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 641
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973"
FT CARBOHYD 689
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 716
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..54
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:10731132, ECO:0000303|Ref.3"
FT /id="VSP_038966"
FT CONFLICT 633..636
FT /note="Missing (in Ref. 3; AAT47768)"
FT /evidence="ECO:0000305"
FT CONFLICT 772
FT /note="L -> I (in Ref. 3; AAT47768)"
FT /evidence="ECO:0000305"
FT CONFLICT 882
FT /note="I -> V (in Ref. 3; AAT47768)"
FT /evidence="ECO:0000305"
FT CONFLICT 975
FT /note="A -> G (in Ref. 3; AAT47768)"
FT /evidence="ECO:0000305"
FT CONFLICT 1458
FT /note="K -> N (in Ref. 4; AAM11425)"
FT /evidence="ECO:0000305"
FT CONFLICT 1584
FT /note="L -> M (in Ref. 4; AAM11425)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1697 AA; 186065 MW; 51FBB405BBECE6F3 CRC64;
MILSKYQTAY ACEGKKLTIE CDPGDVINLI RANYGRFSIT ICNDHGNVEW SVNCMFPKSL
SVLNSRCAHK QSCGVLAATS MFGDPCPGTH KYLEAHYQCI SAAQTSTTTN RPSPPPWVLS
NGPPIFGNGS GLIHPPGVGA GAPPPPRLPT LPGVVGISGN PGLFNVPPQH TAVTHSTPSS
STTAVGGGRL KGGATSTTTT KHPAGRHDGL PPPPQLHHHH NHHGEDTASP TKPSSKLPAG
GNATSPSNTR ILTGVGGSGT DDGTLLTTKS SPNRPPGTAA SGSVVPGNGS VVRTINNINL
NAAGMSGGDD ESKLFCGPTH ARNLYWNMTR VGDVNVQPCP GGAAGIAKWR CVLMKRIPDS
GYDEYDDDIS STTPAPSGGD CLHNSSSCEP PVSMAHKVNQ RLRNFEPTWH PATPDLTQCR
SLWLNNLEMR VNQRDSSLIS IANDMSEVTS SKTLYGGDML VTTKIIQTVS EKMMHDKETF
PDQRQREAMI MELLHCVVKT GSNLLDESQL SSWLDLNPED QMRVATSLLT GLEYNAFLLA
DTIIRERSVV QKVKNILLSV RVLETKTIQS SVVFPDSDQW PLSSDRIELP RAALIDNSEG
GLVRIVFAAF DRLESILKPS YDHFDLKSSR SYVRNTAILS NDSDVNAGEI QQRLRILNSK
VISASLGKGR HIQLSQPITL TLKHLKTENV TNPTCVFWNY IDHAWSANGC SLESTNRTHS
VCSCNHLTNF AILMDVVDEH QHSLFTMFDG NMRIFIYISI GICVVFIVIA LLTLKLFNGV
FVKSARTSIY TSIYLCLLAI ELLFLLGIEQ TETSIFCGFI TIFLHCAILS GTAWFCYEAF
HSYSTLTSDE LLLEVDQTPK VNCYYLLSYG LSLSVVAISL VIDPSTYTQN DYCVLMEANA
LFYATFVIPV LVFFVAAIGY TFLSWIIMCR KSRTGLKTKE HTRLASVRFD IRCSFVFLLL
LSAVWCSAYF YLRGAKMDDD TADVYGYCFI CFNTLLGLYI FVFHCIQNEK IRREYRKYVR
QHAWLPKCLR CSKTSISSGI VTGNGPTAGT LCSVSTSKKP KLPLGVSEEA HDDPQQQQQT
PVPITEDAIM GATSDCELNE AQQRRTLKSG LMTGTLQAPP QTLGGHVVLE RGSTLRSTGH
ASPTSSAGST HLIFAHKQQQ QQQQQGPLGE SYYHQPDYYS WKQPSTGTGG LKTPREYYNN
AGAAASSPQQ AHEVFYWTQK PNSGHNGKKK RGAGGVPASP SGSLHSRTAA ASQVLFYPSY
KKTKPGQPTG YPQYAEALDP PLATGNAAAY YQQQQQLRRQ QLHQQQQQQQ QQQLSSDEEQ
AEQHAHLLHL QRRAGSQQQL PAPPPHMAQY QQEFMQRQYR NKHSNCDLGM GDAYYNQGSV
GGADGGPVYE EILSNRNSDV QHYEVGDFDV DEVYNNSVGT GVFNNMRAAV AAGGSRYGGG
SLSGGSVSSR SQQQQLKKQQ QQQSLAQQRS ARRCTADDDD DEDEEEDEEA TAAEQLHDSV
CDEDEEEDES DLEDDAHGLP PQSDERMRRL MAMQDEDFKR RFQRQLRKHG APLDYGALPP
GAGPQPEHNG AVFGVSGGVG EGSLRGAFRQ QQQQALNAKS PGGRLAVNEL FGHGNSGPPL
PPANQTPAQK RQQLQKLSPQ STTSSSSHTS HSNPNPHPHQ LTHPHPHQHP PHHQQRHLSA
MLDENNTVRC YLEPLAK
