ID   LPK_RHYMA               Reviewed;           8 AA.
AC   P13049;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 3.
DT   11-DEC-2019, entry version 61.
DE   RecName: Full=Leukopyrokinin;
DE            Short=LPK;
DE   AltName: Full=Lem-PK;
OS   Rhyparobia maderae (Madeira cockroach) (Leucophaea maderae).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Blaberidae;
OC   Oxyhaloinae; Rhyparobia.
OX   NCBI_TaxID=36963;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT LEU-8.
RX   PubMed=3015140; DOI=10.1016/0006-291x(86)90315-3;
RA   Nachman R.J., Holman G.M., Cook B.J.;
RT   "Active fragments and analogs of the insect neuropeptide leucopyrokinin:
RT   structure-function studies.";
RL   Biochem. Biophys. Res. Commun. 137:936-942(1986).
RN   [2]
RP   PROTEIN SEQUENCE, AND SYNTHESIS.
RC   TISSUE=Head;
RX   PubMed=2877794; DOI=10.1016/0742-8413(86)90077-0;
RA   Holman G.M., Cook B.J., Nachman R.J.;
RT   "Primary structure and synthesis of a blocked myotropic neuropeptide
RT   isolated from the cockroach, Leucophaea maderae.";
RL   Comp. Biochem. Physiol. 85C:219-224(1986).
CC   -!- FUNCTION: Mediates visceral muscle contractile activity (myotropic
CC       activity).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: An analog without the N-terminal PCA residue was
CC       synthesized and found to exhibit greater activity (144%) than the
CC       parent neuropeptide. The portion of the sequence of LPK most critical
CC       for the myotropic properties is limited to the pentapeptide fragment
CC       FTPRL.
CC   -!- SIMILARITY: Belongs to the pyrokinin family. {ECO:0000305}.
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DR   PIR; A23967; A23967.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   PROSITE; PS00539; PYROKININ; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..8
FT                   /note="Leukopyrokinin"
FT                   /id="PRO_0000044319"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3015140"
FT   MOD_RES         8
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:3015140"
SQ   SEQUENCE   8 AA;  949 MW;  92341771A9D5A1B6 CRC64;
     QTSFTPRL