ID   LPOA_DICC1              Reviewed;         682 AA.
AC   C6CMD7;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Penicillin-binding protein activator LpoA {ECO:0000255|HAMAP-Rule:MF_01890};
DE            Short=PBP activator LpoA {ECO:0000255|HAMAP-Rule:MF_01890};
DE   Flags: Precursor;
GN   Name=lpoA {ECO:0000255|HAMAP-Rule:MF_01890}; OrderedLocusNames=Dd1591_3782;
OS   Dickeya chrysanthemi (strain Ech1591) (Dickeya zeae (strain Ech1591)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Dickeya.
OX   NCBI_TaxID=561229;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ech1591;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA   Balakrishnan V., Glasner J., Perna N.T.;
RT   "Complete sequence of Dickeya zeae Ech1591.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of peptidoglycan synthesis that is essential for
CC       the function of penicillin-binding protein 1A (PBP1a).
CC       {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SUBUNIT: Interacts with PBP1a. {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01890}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_01890};
CC       Periplasmic side {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SIMILARITY: Belongs to the LpoA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01890}.
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DR   EMBL; CP001655; ACT08582.1; -; Genomic_DNA.
DR   RefSeq; WP_015848091.1; NC_012912.1.
DR   AlphaFoldDB; C6CMD7; -.
DR   SMR; C6CMD7; -.
DR   STRING; 561229.Dd1591_3782; -.
DR   EnsemblBacteria; ACT08582; ACT08582; Dd1591_3782.
DR   KEGG; dze:Dd1591_3782; -.
DR   eggNOG; COG3107; Bacteria.
DR   HOGENOM; CLU_026091_1_1_6; -.
DR   OMA; MRLYAMG; -.
DR   Proteomes; UP000002735; Chromosome.
DR   GO; GO:0031241; C:periplasmic side of cell outer membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   HAMAP; MF_01890; LpoA; 1.
DR   InterPro; IPR007443; LpoA.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR38038; PTHR38038; 1.
DR   Pfam; PF04348; LppC; 2.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Cell shape; Lipoprotein; Membrane; Palmitate;
KW   Peptidoglycan synthesis; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
FT   CHAIN           27..682
FT                   /note="Penicillin-binding protein activator LpoA"
FT                   /id="PRO_0000405927"
FT   REGION          240..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           27
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
FT   LIPID           27
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
SQ   SEQUENCE   682 AA;  72145 MW;  962A3E83087508B6 CRC64;
     MLPLNSVRTH AGRLVPVMLA ALFLAGCPSQ APQSPAMQQR VEGKAGASSD YYLQQMQQSS
     DDSKADWQLL AIHALIQEGK LPQAGNQLGT LPSQLGDKQR QEQRLLTAEL AVAQNDMNAA
     NTMLAQLDVK SLSPQQQERY YQAQIKAAQD RTSLTLIRAY IGLEPLLQGD AHQRNIDQTW
     TALTRLNQQD LSSMVINVDE NTLQGWLDLL NLWQTKAQVP SDLQAAIEDW KKRYPRHPAA
     KQLPSQLGGT PPAAAAPTTG ETAPTGGNAI ALLLPLNGQA QAFANAIQQG FSAARSGQAS
     LAMPAQPAQL AQAANNAAAA TPGAPAVPSP ASSTPSAVSP TPAAATTVMP ALTAATAGTI
     PVKVYDTSNQ ALANVIAQAQ KDGATTIVGP LLKNEVEQLP GLNPSLNVLA LNQPEHIQPN
     PNICYFALSP EDEAADAAQF IHKQGKQHPL ILAPRGNLGD RVVAAFAKSW QQQSGGVVLQ
     QRTGSMYDLK QAINSGAGIP LNGQPVITAA SAPQPSTTVG GLTIPNQAPP IAAVTSDGNV
     DAIYIIATPD ELALLKPMID MRNKGASRPA LYASSRSYQA GLGPDFRFEM EGLQFSDIPL
     LTGASPALMQ QVSTQFRNDY SLVRLFAMGM DAWKLASDFS QLHQPGSSLS GATGILSASS
     DCVVNRKLTW LQFRQGQLVP AS