ID   LPOA_EDWTE              Reviewed;         692 AA.
AC   D0ZBY2;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Penicillin-binding protein activator LpoA {ECO:0000255|HAMAP-Rule:MF_01890};
DE            Short=PBP activator LpoA {ECO:0000255|HAMAP-Rule:MF_01890};
DE   Flags: Precursor;
GN   Name=lpoA {ECO:0000255|HAMAP-Rule:MF_01890}; OrderedLocusNames=ETAE_0536;
OS   Edwardsiella tarda (strain EIB202).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=498217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EIB202;
RX   PubMed=19865481; DOI=10.1371/journal.pone.0007646;
RA   Wang Q., Yang M., Xiao J., Wu H., Wang X., Lv Y., Xu L., Zheng H., Wang S.,
RA   Zhao G., Liu Q., Zhang Y.;
RT   "Genome sequence of the versatile fish pathogen Edwardsiella tarda provides
RT   insights into its adaptation to broad host ranges and intracellular
RT   niches.";
RL   PLoS ONE 4:E7646-E7646(2009).
CC   -!- FUNCTION: Regulator of peptidoglycan synthesis that is essential for
CC       the function of penicillin-binding protein 1A (PBP1a).
CC       {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SUBUNIT: Interacts with PBP1a. {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01890}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_01890};
CC       Periplasmic side {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SIMILARITY: Belongs to the LpoA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01890}.
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DR   EMBL; CP001135; ACY83383.1; -; Genomic_DNA.
DR   RefSeq; WP_012847407.1; NC_013508.1.
DR   AlphaFoldDB; D0ZBY2; -.
DR   SMR; D0ZBY2; -.
DR   PRIDE; D0ZBY2; -.
DR   EnsemblBacteria; ACY83383; ACY83383; ETAE_0536.
DR   KEGG; etr:ETAE_0536; -.
DR   HOGENOM; CLU_026091_1_1_6; -.
DR   OMA; MRLYAMG; -.
DR   OrthoDB; 776281at2; -.
DR   Proteomes; UP000002634; Chromosome.
DR   GO; GO:0031241; C:periplasmic side of cell outer membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   HAMAP; MF_01890; LpoA; 1.
DR   InterPro; IPR007443; LpoA.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR38038; PTHR38038; 1.
DR   Pfam; PF04348; LppC; 2.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Cell shape; Lipoprotein; Membrane; Palmitate;
KW   Peptidoglycan synthesis; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
FT   CHAIN           27..692
FT                   /note="Penicillin-binding protein activator LpoA"
FT                   /id="PRO_0000405929"
FT   REGION          297..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           27
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
FT   LIPID           27
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
SQ   SEQUENCE   692 AA;  72621 MW;  DD7E648717BA45F8 CRC64;
     MLSSITVRTK SGRLIPLVLA ATLLAACSGR VSTTPPAPVQ SEATASADYY LQQMQQSSDD
     SKADWQLLAI RALLREGKLP QAADLLGQLP SQLSEAQQLE QRLVSAELEI ARHAPQQAQA
     ILTKLDVAQL SQAQQLRYYQ AVIAAAQGKT TLAQIRAYIA LQPLLTQEKQ RKANIDATWA
     ALSTLTPADL NGMVINANED ILRGWLDLLR LYQDNRQDPA LLKAAIKDWQ TRYPNNPAAT
     LLPSALDNIL HLQSASTASI ALLLPLNGQA KVFSDAIEAG FNAAKNGAFS QNSAPTAAAA
     TDNGAPASSG TLAAATTPSA PADVNAAGAV SPSAQGTDAA APAAPNDSAA LPPLDAAGDP
     IAPSVSPGNP DAHIQVYDTS SQPLPALLSQ AQQAGASLVV GPLLKNNVDQ LNTLSTPLNI
     LALNQPEQVQ NHPNICYFAL SPEDEARDAA RHIWAQGKRT PLLLIPRSPL GDRVAKAFAT
     EWQSLGGGSV LQQTFGSSAE LRSTINGGTG IRLTGQPVSI APAQPASVTI AGLTIPAPVQ
     PPVASGGGVD AVYIIATPAE ITLIKPMIDL ANGTHNGIGL YASSRSYQAG AGPDFRLEME
     GVQFSDIPLL AGSDPAILQQ APAQYRNDYS LMRLYAMGAD AWTLANHFAQ LRQIPGFQVQ
     GATGTLSAND NCVIQRKLPW LQYQKGSIVP VQ