ID   LPOA_SERP5              Reviewed;         674 AA.
AC   A8GJZ0;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Penicillin-binding protein activator LpoA {ECO:0000255|HAMAP-Rule:MF_01890};
DE            Short=PBP activator LpoA {ECO:0000255|HAMAP-Rule:MF_01890};
DE   Flags: Precursor;
GN   Name=lpoA {ECO:0000255|HAMAP-Rule:MF_01890}; OrderedLocusNames=Spro_4336;
OS   Serratia proteamaculans (strain 568).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=399741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=568;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L.,
RA   Vangronsveld J., van der Lelie D., Richardson P.;
RT   "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of peptidoglycan synthesis that is essential for
CC       the function of penicillin-binding protein 1A (PBP1a).
CC       {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SUBUNIT: Interacts with PBP1a. {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01890}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_01890};
CC       Periplasmic side {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SIMILARITY: Belongs to the LpoA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01890}.
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DR   EMBL; CP000826; ABV43430.1; -; Genomic_DNA.
DR   RefSeq; WP_012147033.1; NC_009832.1.
DR   AlphaFoldDB; A8GJZ0; -.
DR   SMR; A8GJZ0; -.
DR   STRING; 399741.Spro_4336; -.
DR   EnsemblBacteria; ABV43430; ABV43430; Spro_4336.
DR   KEGG; spe:Spro_4336; -.
DR   eggNOG; COG3107; Bacteria.
DR   HOGENOM; CLU_026091_1_1_6; -.
DR   OMA; MRLYAMG; -.
DR   OrthoDB; 776281at2; -.
DR   GO; GO:0031241; C:periplasmic side of cell outer membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   HAMAP; MF_01890; LpoA; 1.
DR   InterPro; IPR007443; LpoA.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR38038; PTHR38038; 1.
DR   Pfam; PF04348; LppC; 2.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Cell shape; Lipoprotein; Membrane; Palmitate;
KW   Peptidoglycan synthesis; Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
FT   CHAIN           32..674
FT                   /note="Penicillin-binding protein activator LpoA"
FT                   /id="PRO_5000279767"
FT   REGION          291..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..349
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           32
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
FT   LIPID           32
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
SQ   SEQUENCE   674 AA;  72269 MW;  F045927A135D71E6 CRC64;
     MLSSTFVRTK AGRSKPVRLT AVIAAALFLA GCPSQAPQTP PANIQDEASA SSDYYLQQLQ
     QSSNDNKADW QLLAIRALLR EGKLPQASEQ LNQLPKNLSS VQQVESQLLT AELQVANKSY
     VSARSTLGHI DSGSLSANQL VRFYQAQIAV NQGKASLPLI RAYIAQEPLL TGKAHQNNLD
     QTWQSLLQLT PQDMNSLVIN ANENVLQGWL DLLRVYQDNK QDPDLLKAGI KDWQNRYPQN
     PAAKTLPTQL NQVLHFTQAS TSKIALLLPL NGQAKVFADA IQKGFEAAKN GVTPSTPVQQ
     QQPASVPEQA AQPASTDPNA NGAVSTSAPD AAPVTAAQPS APSTAPITPP QAANAQIKVY
     DTSSQPLAAL LTQAQQDGAT LVVGPLLKEN VDQLASSTTT LNVLALNQPE TPKDNPNICY
     FALSPEDEAR DAARHIWEQQ KRQPLLLIPR GAFGDRVAKA FNQEWQKLGG QTVLQQGIGS
     ASELRQMVNS GGIRMSGTPI STAPAPQAVT IAGLTIPAPP SDTPATSGGS VDSVYIVATQ
     SQLTLIKPMI DMATNSRSKP AMYASSRSYQ AGAGPDFRLE MEGLQFSDIP LLAGANPQLL
     QQASSQFRND YSLVRLYAMG MDAWTLSNHF AEMRQLPGFQ VSGTTGVLTA APGCVINRKL
     PWLQYRQGTV VPVS