ID   LPOA_YERP3              Reviewed;         657 AA.
AC   A7FDZ0;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Penicillin-binding protein activator LpoA {ECO:0000255|HAMAP-Rule:MF_01890};
DE            Short=PBP activator LpoA {ECO:0000255|HAMAP-Rule:MF_01890};
DE   Flags: Precursor;
GN   Name=lpoA {ECO:0000255|HAMAP-Rule:MF_01890};
GN   OrderedLocusNames=YpsIP31758_0475;
OS   Yersinia pseudotuberculosis serotype O:1b (strain IP 31758).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=349747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP 31758;
RX   PubMed=17784789; DOI=10.1371/journal.pgen.0030142;
RA   Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G.,
RA   Fayolle C., Lindler L.E., Carniel E., Ravel J.;
RT   "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the
RT   causative agent of Far East scarlet-like fever.";
RL   PLoS Genet. 3:1508-1523(2007).
CC   -!- FUNCTION: Regulator of peptidoglycan synthesis that is essential for
CC       the function of penicillin-binding protein 1A (PBP1a).
CC       {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SUBUNIT: Interacts with PBP1a. {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01890}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_01890};
CC       Periplasmic side {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SIMILARITY: Belongs to the LpoA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01890}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABS49021.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP000720; ABS49021.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_012303495.1; NC_009708.1.
DR   AlphaFoldDB; A7FDZ0; -.
DR   SMR; A7FDZ0; -.
DR   EnsemblBacteria; ABS49021; ABS49021; YpsIP31758_0475.
DR   KEGG; ypi:YpsIP31758_0475; -.
DR   HOGENOM; CLU_026091_1_1_6; -.
DR   Proteomes; UP000002412; Chromosome.
DR   GO; GO:0031241; C:periplasmic side of cell outer membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   HAMAP; MF_01890; LpoA; 1.
DR   InterPro; IPR007443; LpoA.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR38038; PTHR38038; 1.
DR   Pfam; PF04348; LppC; 2.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Cell shape; Lipoprotein; Membrane; Palmitate;
KW   Peptidoglycan synthesis; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
FT   CHAIN           26..657
FT                   /note="Penicillin-binding protein activator LpoA"
FT                   /id="PRO_0000405954"
FT   LIPID           26
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
FT   LIPID           26
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
SQ   SEQUENCE   657 AA;  70216 MW;  6AF96F352B8941C1 CRC64;
     MLSSTFVRSK AGLVPVILAA LILAACTGDA PQTPPPVNIQ DEASANSDYY LQQLQQSSDD
     NKADWQLLAI RALLREAKVP QAAEQLSTLP ANLSDTQRQE QQLLAAELLI AQKNTPAAAD
     ILAKLEATQL SANQKVRYYQ AQIAANQDKA TLPLIRAFIA QEPLLTDKAH QDNIDGTWQS
     LSQLTPQELN TMVINADENV LQGWLDLLRV YQDNKQDPEL LKAGIKDWQT RYPQNPAAKN
     LPTALTQISN FSQASTAKIA LLLPLSGPAQ VFADAIQQGF TAAQNGSAVT ASVPVTPNVT
     ESSPTDTAAV VSDDTPATLP APVTPPVVTN AQVKIYDTNT QPLAALLAQA QQDGATLVVG
     PLLKPEVEQL SATPSTLNIL ALNQPEASNN SPNICYFALS PEDEARDAAH HLWEQQKRMP
     LLLVPRGALG ERIAKAFADE WQKQGGQTVL QQNFGSTTEL KQSINSGAGI RLTGTPVSVS
     NVAAAPASVT IAGLTIPAPP IDAPVVSTSS SGNIDAVYII ATPSELTLIK PMIDMATSSR
     SKPALFASSR SYQAGAGPDY RLEMEGIQFS DIPLMAGSNP ALLQQASAKY ANDYSLVRLY
     AMGIDAWALA NHFSEMRQIP GFQVKGVTGD LTASSDCVIT RKLPWLQYRQ GMVVPLA