ID   LPOA_YERPG              Reviewed;         657 AA.
AC   A9R1Q6;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Penicillin-binding protein activator LpoA {ECO:0000255|HAMAP-Rule:MF_01890};
DE            Short=PBP activator LpoA {ECO:0000255|HAMAP-Rule:MF_01890};
DE   Flags: Precursor;
GN   Name=lpoA {ECO:0000255|HAMAP-Rule:MF_01890};
GN   OrderedLocusNames=YpAngola_A1120;
OS   Yersinia pestis bv. Antiqua (strain Angola).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=349746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Angola;
RX   PubMed=20061468; DOI=10.1128/jb.01518-09;
RA   Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S.,
RA   Achtman M., Lindler L.E., Ravel J.;
RT   "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals
RT   new insights into the evolution and pangenome of the plague bacterium.";
RL   J. Bacteriol. 192:1685-1699(2010).
CC   -!- FUNCTION: Regulator of peptidoglycan synthesis that is essential for
CC       the function of penicillin-binding protein 1A (PBP1a).
CC       {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SUBUNIT: Interacts with PBP1a. {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01890}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_01890};
CC       Periplasmic side {ECO:0000255|HAMAP-Rule:MF_01890}.
CC   -!- SIMILARITY: Belongs to the LpoA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01890}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABX88080.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP000901; ABX88080.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041854864.1; NZ_CP009935.1.
DR   AlphaFoldDB; A9R1Q6; -.
DR   SMR; A9R1Q6; -.
DR   KEGG; ypg:YpAngola_A1120; -.
DR   PATRIC; fig|349746.12.peg.2071; -.
DR   GO; GO:0031241; C:periplasmic side of cell outer membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   HAMAP; MF_01890; LpoA; 1.
DR   InterPro; IPR007443; LpoA.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR38038; PTHR38038; 1.
DR   Pfam; PF04348; LppC; 2.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Cell shape; Lipoprotein; Membrane; Palmitate;
KW   Peptidoglycan synthesis; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
FT   CHAIN           26..657
FT                   /note="Penicillin-binding protein activator LpoA"
FT                   /id="PRO_0000405953"
FT   LIPID           26
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
FT   LIPID           26
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01890"
SQ   SEQUENCE   657 AA;  70211 MW;  006B3E7359169FDB CRC64;
     MLSSTFVRSK AGLVPVILAA LILAACTGDA PQTPPPVNIQ DEASANSDYY LQQLQQSSDD
     NKADWQLLAI RALLREAKVP QAAEQLSTLP ANLSDTQRQE QQLLAAELLI AQKNTPAAAD
     ILAKLEATQL SANQKVRYYQ AQIAANQDKA TLPLIRAFIA QEPLLTDKAH QDNIDGTWQS
     LSQLTPQELN TMVINADENV LQGWLDLLRV YQDNKQDPKL LKAGIKDWQT RYPQNPAAKN
     LPTALTQISN FSQASTAKIA LLLPLSGPAQ VFADAIQQGF TAAQNGSAVT ASVPVTPNVT
     ESSPTDTAAV VSDDTPATLP APVPPPVVTN AQVKIYDTNT QPLAALLAQA QQDGATLVVG
     PLLKPEVEQL SATPSTLNIL ALNQPEASNN SPNICYFALS PEDEARDAAH HLWEQQKRMP
     LLLVPRGALG ERIAKAFADE WQKQGGQTVL QQNFGSTTEL KQSINSGAGI RLTGTPVSVS
     NVAAAPASVT IAGLTIPAPP IDAPVVSTSS SGNIDAVYII ATPSELTLIK PMIDMATSSR
     SKPALFASSR SYQAGAGPDY RLEMEGIQFS DIPLMAGSNP ALLQQASAKY ANDYSLVRLY
     AMGIDAWALA NHFSEMRQIP GFQVKGVTGD LTASSDCVIT RKLPWLQYRQ GMVVPLA