LPOB_SALTY
ID LPOB_SALTY Reviewed; 212 AA.
AC Q8ZQ08;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Penicillin-binding protein activator LpoB {ECO:0000255|HAMAP-Rule:MF_01889};
DE Short=PBP activator LpoB {ECO:0000255|HAMAP-Rule:MF_01889};
DE Flags: Precursor;
GN Name=lpoB {ECO:0000255|HAMAP-Rule:MF_01889}; OrderedLocusNames=STM1207;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Regulator of peptidoglycan synthesis that is essential for
CC the function of penicillin-binding protein 1B (PBP1b).
CC {ECO:0000255|HAMAP-Rule:MF_01889}.
CC -!- SUBUNIT: Interacts with PBP1b. {ECO:0000255|HAMAP-Rule:MF_01889}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_01889}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_01889};
CC Periplasmic side {ECO:0000255|HAMAP-Rule:MF_01889}.
CC -!- SIMILARITY: Belongs to the LpoB family. {ECO:0000255|HAMAP-
CC Rule:MF_01889}.
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DR EMBL; AE006468; AAL20136.1; -; Genomic_DNA.
DR RefSeq; NP_460177.1; NC_003197.2.
DR RefSeq; WP_000164359.1; NC_003197.2.
DR PDB; 4Q6L; X-ray; 2.20 A; A=77-212.
DR PDB; 4Q6V; X-ray; 1.97 A; A=77-212.
DR PDBsum; 4Q6L; -.
DR PDBsum; 4Q6V; -.
DR AlphaFoldDB; Q8ZQ08; -.
DR SMR; Q8ZQ08; -.
DR STRING; 99287.STM1207; -.
DR PaxDb; Q8ZQ08; -.
DR EnsemblBacteria; AAL20136; AAL20136; STM1207.
DR GeneID; 1252725; -.
DR KEGG; stm:STM1207; -.
DR PATRIC; fig|99287.12.peg.1276; -.
DR HOGENOM; CLU_092328_0_0_6; -.
DR OMA; AMQPMVG; -.
DR PhylomeDB; Q8ZQ08; -.
DR BioCyc; SENT99287:STM1207-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0031241; C:periplasmic side of cell outer membrane; IBA:GO_Central.
DR GO; GO:0030234; F:enzyme regulator activity; IBA:GO_Central.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR HAMAP; MF_01889; LpoB; 1.
DR InterPro; IPR014094; LpoB.
DR PANTHER; PTHR40593; PTHR40593; 1.
DR Pfam; PF13036; LpoB; 1.
DR TIGRFAMs; TIGR02722; lp; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Cell shape; Lipoprotein; Membrane;
KW Palmitate; Peptidoglycan synthesis; Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01889"
FT CHAIN 20..212
FT /note="Penicillin-binding protein activator LpoB"
FT /id="PRO_0000405790"
FT REGION 28..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..56
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 20
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01889"
FT LIPID 20
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01889"
FT HELIX 79..91
FT /evidence="ECO:0007829|PDB:4Q6V"
FT STRAND 100..104
FT /evidence="ECO:0007829|PDB:4Q6V"
FT STRAND 108..113
FT /evidence="ECO:0007829|PDB:4Q6V"
FT HELIX 117..130
FT /evidence="ECO:0007829|PDB:4Q6V"
FT HELIX 131..133
FT /evidence="ECO:0007829|PDB:4Q6L"
FT HELIX 139..148
FT /evidence="ECO:0007829|PDB:4Q6V"
FT HELIX 160..170
FT /evidence="ECO:0007829|PDB:4Q6V"
FT STRAND 173..182
FT /evidence="ECO:0007829|PDB:4Q6V"
FT STRAND 188..195
FT /evidence="ECO:0007829|PDB:4Q6V"
FT TURN 196..198
FT /evidence="ECO:0007829|PDB:4Q6V"
FT STRAND 201..208
FT /evidence="ECO:0007829|PDB:4Q6V"
SQ SEQUENCE 212 AA; 22524 MW; 528D03D50040DBE8 CRC64;
MTKMHRYAAI AALAIFLSGC MAQRQPAPVE EVKPAPEQPA QPPQPPVVPS VPTIPQQPGP
IEHEDQTGQP APKVRHYDWN GAMQPLVSKM LQADGVTAGS VLLVDSVNNR TNGSLNANEA
TETLRNALAN NGKFTLVSVQ QLSMAKQQLG LSPQDSLGTR SKAIGIARNV GAQYVLYSSA
SGNVNAPALQ MQLMLVQTGE IIWSGKGAVQ QQ
