LPP20_HELPY
ID LPP20_HELPY Reviewed; 175 AA.
AC P0A0V0; P53436;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=LPP20 lipoprotein;
DE Flags: Precursor;
GN Name=lpp20; OrderedLocusNames=HP_1456;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 40-71 AND 109-134,
RP AND MASS SPECTROMETRY.
RC STRAIN=DSM 4867 / CCUG 17874 / NCTC 11638;
RX PubMed=7928954; DOI=10.1128/jb.176.19.5938-5948.1994;
RA Kostrzynska M., O'Toole P.W., Taylor D.E., Trust T.J.;
RT "Molecular characterization of a conserved 20-kilodalton membrane-
RT associated lipoprotein antigen of Helicobacter pylori.";
RL J. Bacteriol. 176:5938-5948(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: Could play a role in the pathogenesis of H.pylori by serving
CC as an inflammatory mediator.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
CC -!- PTM: The N-terminus is blocked.
CC -!- MASS SPECTROMETRY: Mass=18283; Mass_error=150; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:7928954};
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DR EMBL; U12429; AAA50860.1; -; Genomic_DNA.
DR EMBL; AE000511; AAD08494.1; -; Genomic_DNA.
DR PIR; H64701; H64701.
DR RefSeq; NP_208247.1; NC_000915.1.
DR RefSeq; WP_000795978.1; NC_018939.1.
DR AlphaFoldDB; P0A0V0; -.
DR SMR; P0A0V0; -.
DR IntAct; P0A0V0; 2.
DR STRING; 85962.C694_07540; -.
DR PaxDb; P0A0V0; -.
DR EnsemblBacteria; AAD08494; AAD08494; HP_1456.
DR KEGG; hpy:HP_1456; -.
DR PATRIC; fig|85962.47.peg.1566; -.
DR OMA; NKEYSAQ; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR002217; Lipo_LPP20.
DR InterPro; IPR024952; Lipo_LPP20-like.
DR Pfam; PF02169; LPP20; 1.
DR PIRSF; PIRSF011368; Lipo_LPP20; 1.
DR PRINTS; PR01019; LIPOLPP20.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Direct protein sequencing; Lipoprotein; Membrane;
KW Palmitate; Reference proteome; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000305"
FT CHAIN 22..175
FT /note="LPP20 lipoprotein"
FT /id="PRO_0000018105"
FT LIPID 22
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000305"
FT LIPID 22
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000305"
FT VARIANT 16
FT /note="A -> T (in strain: NCTC 11638)"
FT VARIANT 152
FT /note="V -> G (in strain: NCTC 11638)"
SQ SEQUENCE 175 AA; 19108 MW; BBB8359E03C8458A CRC64;
MKNQVKKILG MSVVAAMVIV GCSHAPKSGI SKSNKAYKEA TKGAPDWVVG DLEKVAKYEK
YSGVFLGRAE DLITNNDVDY STNQATAKAR ANLAANLKST LQKDLENEKT RTVDASGKRS
ISGTDTEKIS QLVDKELIAS KMLARYVGKD RVFVLVGLDK QIVDKVREEL GMVKK
