LPP4_ARATH
ID LPP4_ARATH Reviewed; 308 AA.
AC Q0WNG6; Q8LAS9; Q9LJQ8;
DT 19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Probable lipid phosphate phosphatase 4;
DE Short=AtLPP4;
DE EC=3.1.3.-;
DE AltName: Full=Phosphatidic acid phosphatase 4;
DE Short=AtPAP4;
GN Name=LPP4; OrderedLocusNames=At3g18220; ORFNames=MIE15.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC family. {ECO:0000305}.
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DR EMBL; AP000414; BAB01172.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76067.1; -; Genomic_DNA.
DR EMBL; AK229475; BAF01333.1; -; mRNA.
DR EMBL; AY087632; AAM65171.1; -; mRNA.
DR RefSeq; NP_566602.1; NM_112706.3.
DR AlphaFoldDB; Q0WNG6; -.
DR STRING; 3702.AT3G18220.1; -.
DR PaxDb; Q0WNG6; -.
DR PRIDE; Q0WNG6; -.
DR ProteomicsDB; 238445; -.
DR EnsemblPlants; AT3G18220.1; AT3G18220.1; AT3G18220.
DR GeneID; 821350; -.
DR Gramene; AT3G18220.1; AT3G18220.1; AT3G18220.
DR KEGG; ath:AT3G18220; -.
DR Araport; AT3G18220; -.
DR TAIR; locus:2089643; AT3G18220.
DR eggNOG; KOG3030; Eukaryota.
DR HOGENOM; CLU_021458_5_1_1; -.
DR InParanoid; Q0WNG6; -.
DR OMA; CTPLIVI; -.
DR OrthoDB; 1621899at2759; -.
DR PhylomeDB; Q0WNG6; -.
DR PRO; PR:Q0WNG6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q0WNG6; baseline and differential.
DR Genevisible; Q0WNG6; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008195; F:phosphatidate phosphatase activity; IBA:GO_Central.
DR GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro.
DR InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR InterPro; IPR043216; PA_PP_rel.
DR PANTHER; PTHR10165; PTHR10165; 1.
DR Pfam; PF01569; PAP2; 1.
DR SMART; SM00014; acidPPc; 1.
DR SUPFAM; SSF48317; SSF48317; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..308
FT /note="Probable lipid phosphate phosphatase 4"
FT /id="PRO_0000425225"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 274..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 139..141
FT /note="KFH -> VY (in Ref. 1; BAB01172)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="G -> D (in Ref. 4; AAM65171)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 308 AA; 35102 MW; E2AC1DA2821E2726 CRC64;
MAKIMLGSHS VKSHGWKVAR EHLCDWLILV VLGLIDIVLN VIEPFHRYIG PDMLTDLTFP
FYEDTIPMWA VPIICILVPI CIFIVYYYYR RDVYDLHHAI LGIGFSCLVT GVTTDSIKDA
VGRPRPNFFY RCFPNGKPKF HPDTKDVVCH GVKKIIKEGY KSFPSGHTSW SFAGLTFLAW
YLSGKIKVFD RRGHVAKLCL VFLPILISIL IGISRVDDYW HHWTDVFAGA IIGIFVASFS
YLHFFPYPYD ENGWAPHAYF RMLAERSTGR ATTMTRTGSR GMLGNDVEPG NSASSPHDRH
RESTDSDF
