LPPA_MYCTU
ID LPPA_MYCTU Reviewed; 219 AA.
AC P9WK81; L0TCP2; P95010; Q7D6Y4;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 32.
DE RecName: Full=Putative lipoprotein LppA;
DE Flags: Precursor;
GN Name=lppA; OrderedLocusNames=Rv2543;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 34-219.
RC STRAIN=ATCC 25618 / H37Rv;
RA Grana M., Miras I., Haouz A., Winter N., Buschiazzo A., Bellinzoni M.,
RA Alzari P.M.;
RT "Crystal structure of the putative lipoprotein lppA from Mycobacterium
RT tuberculosis.";
RL Submitted (AUG-2008) to the PDB data bank.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the mycobacteriales LppA/LppB family.
CC {ECO:0000305}.
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DR EMBL; AL123456; CCP45338.1; -; Genomic_DNA.
DR PIR; C70659; C70659.
DR RefSeq; NP_217059.1; NC_000962.3.
DR RefSeq; WP_003900846.1; NZ_NVQJ01000032.1.
DR PDB; 2V7S; X-ray; 1.96 A; A=34-219.
DR PDBsum; 2V7S; -.
DR AlphaFoldDB; P9WK81; -.
DR SMR; P9WK81; -.
DR STRING; 83332.Rv2543; -.
DR PaxDb; P9WK81; -.
DR DNASU; 888052; -.
DR GeneID; 888052; -.
DR KEGG; mtu:Rv2543; -.
DR TubercuList; Rv2543; -.
DR eggNOG; ENOG5031J3X; Bacteria.
DR PhylomeDB; P9WK81; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR032018; LppA/LppB/LprP.
DR Pfam; PF16708; LppA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Lipoprotein; Membrane; Palmitate;
KW Reference proteome; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..219
FT /note="Putative lipoprotein LppA"
FT /id="PRO_0000361670"
FT LIPID 33
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 33
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255"
FT HELIX 41..57
FT /evidence="ECO:0007829|PDB:2V7S"
FT HELIX 58..60
FT /evidence="ECO:0007829|PDB:2V7S"
FT HELIX 63..84
FT /evidence="ECO:0007829|PDB:2V7S"
FT STRAND 90..92
FT /evidence="ECO:0007829|PDB:2V7S"
FT HELIX 96..104
FT /evidence="ECO:0007829|PDB:2V7S"
FT STRAND 109..111
FT /evidence="ECO:0007829|PDB:2V7S"
FT TURN 113..115
FT /evidence="ECO:0007829|PDB:2V7S"
FT STRAND 116..118
FT /evidence="ECO:0007829|PDB:2V7S"
FT STRAND 124..128
FT /evidence="ECO:0007829|PDB:2V7S"
FT HELIX 132..147
FT /evidence="ECO:0007829|PDB:2V7S"
FT TURN 148..150
FT /evidence="ECO:0007829|PDB:2V7S"
FT STRAND 153..155
FT /evidence="ECO:0007829|PDB:2V7S"
FT STRAND 159..162
FT /evidence="ECO:0007829|PDB:2V7S"
FT STRAND 164..170
FT /evidence="ECO:0007829|PDB:2V7S"
FT STRAND 173..188
FT /evidence="ECO:0007829|PDB:2V7S"
FT HELIX 195..198
FT /evidence="ECO:0007829|PDB:2V7S"
SQ SEQUENCE 219 AA; 24180 MW; C3DCF4370051F552 CRC64;
MIAPQPISRT LPRWQRIVAL TMIGISTALI GGCTMDHNPD TSRRLTGEQK IQLIDSMRNK
GSYEAARERL TATARIIADR VSAAIPGQTW KFDDDPNIQQ SDRNGALCDK LTADIARRPI
ANSVMFGATF SAEDFKIAAN IVREEAAKYG ATTESSLFNE SAKRDYDVQG NGYEFRLLQI
KFATLNITGD CFLLQKVLDL PAGQLPPEPP IWPTTSTPH
