LPPC_MYCTU
ID LPPC_MYCTU Reviewed; 201 AA.
AC P9WFN3; L0T886; O07722; P67224;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 11-NOV-2015, sequence version 2.
DT 03-AUG-2022, entry version 43.
DE RecName: Full=Putative lipoprotein LppC {ECO:0000312|EMBL:CCP44678.1};
DE AltName: Full=UPF0098 protein Rv1911c;
DE Flags: Precursor;
GN Name=lppC {ECO:0000312|EMBL:CCP44678.1}; OrderedLocusNames=Rv1911c;
GN ORFNames=MTCY180.07;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND DOMAIN.
RX PubMed=25041568; DOI=10.1111/cbdd.12365;
RA Ocampo M., Curtidor H., Vanegas M., Patarroyo M.A., Patarroyo M.E.;
RT "Specific interaction between Mycobacterium tuberculosis lipoprotein-
RT derived peptides and target cells inhibits mycobacterial entry in vitro.";
RL Chem. Biol. Drug Des. 84:626-641(2014).
CC -!- FUNCTION: Probably involved in bacterial recognition and uptake by its
CC host (human) (PubMed:25041568). {ECO:0000269|PubMed:25041568}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC Cell surface {ECO:0000269|PubMed:25041568}. Note=Immunoelectron
CC microscopy indicates this protein is displaced from the cell surface
CC (PubMed:25041568). {ECO:0000269|PubMed:25041568}.
CC -!- DOMAIN: Fragments of the mature protein (residues 77-96, 97-116 and
CC 117-136) prevent uptake of M.tuberculosis by a human macrophage-like
CC cell line (PubMed:25041568). {ECO:0000269|PubMed:25041568}.
CC -!- SIMILARITY: Belongs to the UPF0098 family. {ECO:0000305}.
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DR EMBL; AL123456; CCP44678.1; -; Genomic_DNA.
DR PIR; D70519; D70519.
DR RefSeq; NP_216427.1; NC_000962.3.
DR RefSeq; WP_003409568.1; NZ_NVQJ01000034.1.
DR AlphaFoldDB; P9WFN3; -.
DR SMR; P9WFN3; -.
DR STRING; 83332.Rv1911c; -.
DR PaxDb; P9WFN3; -.
DR DNASU; 885646; -.
DR GeneID; 885646; -.
DR KEGG; mtu:Rv1911c; -.
DR PATRIC; fig|83332.111.peg.2126; -.
DR TubercuList; Rv1911c; -.
DR eggNOG; COG1881; Bacteria.
DR PhylomeDB; P9WFN3; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00865; PEBP_bact_arch; 1.
DR Gene3D; 3.90.280.10; -; 1.
DR InterPro; IPR008914; PEBP.
DR InterPro; IPR036610; PEBP-like_sf.
DR InterPro; IPR005247; YbhB_YbcL.
DR PANTHER; PTHR30289; PTHR30289; 1.
DR Pfam; PF01161; PBP; 1.
DR SUPFAM; SSF49777; SSF49777; 1.
DR TIGRFAMs; TIGR00481; TIGR00481; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 24..201
FT /note="Putative lipoprotein LppC"
FT /id="PRO_0000137907"
FT REGION 77..96
FT /note="Prevents bacterial uptake by a human macrophage-like
FT cell line"
FT /evidence="ECO:0000269|PubMed:25041568"
FT REGION 97..116
FT /note="Prevents bacterial uptake by a human macrophage-like
FT cell line"
FT /evidence="ECO:0000269|PubMed:25041568"
FT REGION 117..136
FT /note="Prevents bacterial uptake by a human macrophage-like
FT cell line"
FT /evidence="ECO:0000269|PubMed:25041568"
FT REGION 122..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 24
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 24
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ SEQUENCE 201 AA; 19798 MW; 42977DA20934782B CRC64;
MTSTLHRTPL ATAGLALVVA LGGCGGGGGD SRETPPYVPK ATTVDATTPA PAAEPLTIAS
PMFADGAPIP VQFSCKGANV APPLTWSSPA GAAELALVVD DPDAVGGLYV HWIVTGIAPG
SGSTADGQTP AGGHSVPNSG GRQGYFGPCP PAGTGTHHYR FTLYHLPVAL QLPPGATGVQ
AAQAIAQAAS GQARLVGTFE G
