ID   LPPE_MYCTU              Reviewed;         140 AA.
AC   O07750; F2GHR3; I6YBU9; L0T7Z2;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Probable lipoprotein LppE {ECO:0000305};
DE   Flags: Precursor;
GN   Name=lppE; OrderedLocusNames=Rv1881c; ORFNames=LH57_10245;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=21920479; DOI=10.1016/j.jprot.2011.08.016;
RA   de Souza G.A., Leversen N.A., Maalen H., Wiker H.G.;
RT   "Bacterial proteins with cleaved or uncleaved signal peptides of the
RT   general secretory pathway.";
RL   J. Proteomics 75:502-510(2011).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC       Note=Found in membrane and whole cell lysates.
CC       {ECO:0000269|PubMed:21920479}.
CC   -!- SIMILARITY: Belongs to the mycobacterial 19 kDa antigen family.
CC       {ECO:0000305}.
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DR   EMBL; CP009480; AIR14629.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP44647.1; -; Genomic_DNA.
DR   RefSeq; NP_216397.1; NC_000962.3.
DR   RefSeq; WP_003409409.1; NZ_NVQJ01000013.1.
DR   AlphaFoldDB; O07750; -.
DR   SMR; O07750; -.
DR   STRING; 83332.Rv1881c; -.
DR   PaxDb; O07750; -.
DR   DNASU; 885762; -.
DR   GeneID; 885762; -.
DR   KEGG; mtu:Rv1881c; -.
DR   PATRIC; fig|83332.111.peg.2091; -.
DR   TubercuList; Rv1881c; -.
DR   eggNOG; ENOG5031JVB; Bacteria.
DR   HOGENOM; CLU_131476_0_0_11; -.
DR   OMA; ERVIPQW; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008691; LpqH.
DR   Pfam; PF05481; Myco_19_kDa; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           22..140
FT                   /note="Probable lipoprotein LppE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT                   /id="PRO_0000434268"
FT   LIPID           22
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           22
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   140 AA;  14975 MW;  312A576A87AEB1F9 CRC64;
     MCNRLVTVTG VAMVVAAGLS ACGQAQTVPR KAARLTIDGV THTTRPATCS QEHSYRTIDI
     RNHDSTVQAV VLLSGDRVIP QWVKIRNVDG FNGSFWHGGV GNARADRARN TYTVAGSAYG
     ISSKKPNTVV STDFNILAEC