ID   LPPO_MYCTU              Reviewed;         171 AA.
AC   P9WK71; L0TBV2; Q50675;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Putative lipoprotein LppO;
DE   Flags: Precursor;
GN   Name=lppO; OrderedLocusNames=Rv2290; ORFNames=MTCY339.20c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45072.1; -; Genomic_DNA.
DR   PIR; F70732; F70732.
DR   RefSeq; NP_216806.1; NC_000962.3.
DR   RefSeq; WP_003900493.1; NZ_NVQJ01000012.1.
DR   AlphaFoldDB; P9WK71; -.
DR   SMR; P9WK71; -.
DR   STRING; 83332.Rv2290; -.
DR   PaxDb; P9WK71; -.
DR   DNASU; 887203; -.
DR   GeneID; 887203; -.
DR   KEGG; mtu:Rv2290; -.
DR   TubercuList; Rv2290; -.
DR   eggNOG; ENOG50307CA; Bacteria.
DR   OMA; FGIHVTC; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008691; LpqH.
DR   Pfam; PF05481; Myco_19_kDa; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..171
FT                   /note="Putative lipoprotein LppO"
FT                   /id="PRO_0000018114"
FT   LIPID           29
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           29
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   171 AA;  17342 MW;  9B8FA586A38F4253 CRC64;
     MTDPRHTVRI AVGATALGVS ALGATLPACS AHSGPGSPPS APSAPAAATV MVEGHTHTIS
     GVVECRTSPA VRTATPSESG TQTTRVNAHD DSASVTLSLS DSTPPDVNGF GISLKIGSVD
     YQMPYQPVQS PTQVEATRQG KSYTLTGTGH AVIPGQTGMR ELPFGVHVTC P