ID   LPPRC_XENTR             Reviewed;        1391 AA.
AC   Q28C74;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Leucine-rich PPR motif-containing protein, mitochondrial;
DE   Flags: Precursor;
GN   Name=lrpprc; ORFNames=TTpA007l07.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in RNA metabolism in both nuclei and
CC       mitochondria. May bind mature mRNA in the nucleus outer membrane. In
CC       mitochondria binds to poly(A) mRNA. May be involved in transcription
CC       regulation. Binds single-stranded DNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
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DR   EMBL; CR942422; CAJ83132.1; -; mRNA.
DR   RefSeq; NP_001039203.1; NM_001045738.1.
DR   AlphaFoldDB; Q28C74; -.
DR   STRING; 8364.ENSXETP00000060744; -.
DR   PaxDb; Q28C74; -.
DR   PRIDE; Q28C74; -.
DR   GeneID; 734062; -.
DR   KEGG; xtr:734062; -.
DR   CTD; 10128; -.
DR   Xenbase; XB-GENE-1014657; lrpprc.
DR   eggNOG; KOG4318; Eukaryota.
DR   InParanoid; Q28C74; -.
DR   OrthoDB; 1344243at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0070129; P:regulation of mitochondrial translation; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR033490; LRP130.
DR   InterPro; IPR002885; Pentatricopeptide_repeat.
DR   InterPro; IPR033443; PPR_long.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR46669; PTHR46669; 2.
DR   Pfam; PF01535; PPR; 3.
DR   Pfam; PF13812; PPR_3; 1.
DR   Pfam; PF17177; PPR_long; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   TIGRFAMs; TIGR00756; PPR; 4.
DR   PROSITE; PS51375; PPR; 15.
PE   2: Evidence at transcript level;
KW   DNA-binding; Mitochondrion; Nucleus; Reference proteome; Repeat;
KW   RNA-binding; Transcription; Transcription regulation; Transit peptide;
KW   Transport.
FT   TRANSIT         1..42
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           43..1391
FT                   /note="Leucine-rich PPR motif-containing protein,
FT                   mitochondrial"
FT                   /id="PRO_0000338618"
FT   REPEAT          110..144
FT                   /note="PPR 1"
FT   REPEAT          145..179
FT                   /note="PPR 2"
FT   REPEAT          180..214
FT                   /note="PPR 3"
FT   REPEAT          215..249
FT                   /note="PPR 4"
FT   REPEAT          250..284
FT                   /note="PPR 5"
FT   REPEAT          389..425
FT                   /note="PPR 6"
FT   REPEAT          704..738
FT                   /note="PPR 7"
FT   REPEAT          741..775
FT                   /note="PPR 8"
FT   REPEAT          779..813
FT                   /note="PPR 9"
FT   REPEAT          815..850
FT                   /note="PPR 10"
FT   REPEAT          948..982
FT                   /note="PPR 11"
FT   REPEAT          1028..1062
FT                   /note="PPR 12"
FT   REPEAT          1063..1093
FT                   /note="PPR 13"
FT   REPEAT          1100..1134
FT                   /note="PPR 14"
FT   REPEAT          1310..1344
FT                   /note="PPR 15"
FT   REGION          1118..1387
FT                   /note="RNA-binding"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1391 AA;  156250 MW;  26245D6F7DEA4C9E CRC64;
     MSALLAGARF LLRPGLRALP APCVRLSPGQ GRYLNNTPGH FAIAAQQKGH IHEEPVSAVR
     AKQAQQFDWA LNKLDSSVRR TGRITKTLLQ KIFHDVCRTG YPSSNQALLL LRSCGSLLPE
     LQMSERTEMA HRIWEKLQEL GAVFDVSHYN ALLKVYLQNE HKFSPTEYLA KMEAANVQPN
     RVTYQRLIAA YCNEGDIEGA SKILGFMKNK DLPITEAVFN TLVTGHARAG DMENAKNILS
     VMRSAGIEPG PETYVALLTA YAEKGDINNI KQTLENVEKN EGSLTDRDLM QVIWSLAKAG
     YPQYVQDIVE RMRYDRGYIP DAMNLCLSLM TQGFEDVAFL VLKSFSAASH DSPNGDSLHH
     GNFFLRHCVN LDKPANKVKQ FCDGLKEENL HSAPLQFALY CSLDAKKADL ALELMKMMKQ
     EGMPVRPHYC WPLLISFQKE KNAEGTIKVI KALSEIGVEL DVETYSNYVL SVFNDVKSAR
     AQLQEHGCTV DSSWFNLAEL RHDAVSGNLE EVYSLLSSPS FPSVDLGHFR GSLITAFKRS
     NNVDLKAKIT ELLYKDGRYC QAASGPNEAV GYFLYNLIDS MSDAEVQAKE EHLRQYFHQL
     KNANIVISAN IYRGIRNLLD SSHVPELIKD VIVLVDSQET LTSSDIAKSA ELKASTLEEE
     IETLKAENKP FGDVLKQLVM IHCSEENMQK ALEVKAKYEQ ENLAIGTYAA LIQLCCRHDN
     PDEALNLKQE LNRKDSSAVL DTSKYLALVK VFGKNGRIAD AINVLKEMKE KDVPLKETTT
     TSFFHILNAA ALRGDAETVD KIHESIVTLG LAKPTSNLCS PLVSVHLEKG DLPAAMETLF
     TCSKKYNCMP RLHDVLCRLV EKGDTDLLQK AMDHISQERG EMAMLYDLLF AFLHTGKYKE
     ARKIIETPGL RARPGRLQWF AEKCIATNQM EALENLVDMT QKLFECDRDD MYYYLLKLCK
     ENDDWKKADS AWTKIQEENV IPRERTLRLL ADIFRRNGQE VPFDVPETWY KDAAESKVLA
     SSSAPSSPES SFQKRVQVLS KKNRAKDAYE AFMEGENNGT AMSASAYSSL IRSMLSEGML
     EEAKKVLNTA ENHIKGFTLN DAASSLLIIT QVRRDYLKDA LASLKAMLEG DKVPTQLAVT
     RLVQALALKG DLEGIEVVEN MMRNIGSSIR LSQMLFINNK MLAHLKRGKT EEAIELIEPL
     YTGTDSQVTS ISYVFRKAME EKMESALEKL SGMAERLANQ FAVYRPVTDL FLQYIQVGRK
     DDARFLLQRC GSIAEQTPVL VSFISRSAQI PGQAQLIKDL LELIPEFSER ETAYSYLMKC
     YATDKDATAA TALYEKMKSE SVSPDELFLK RLAVLLREAG EPVPFSEPPE SFKFYADKLK
     KDKADSYDDE H