ID   LPPW_MYCTU              Reviewed;         314 AA.
AC   P9WK67; L0TDW9; P65304; Q10823;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Putative lipoprotein LppW;
DE   Flags: Precursor;
GN   Name=lppW; OrderedLocusNames=Rv2905; ORFNames=MTCY274.36;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
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DR   EMBL; AL123456; CCP45707.1; -; Genomic_DNA.
DR   PIR; D70927; D70927.
DR   RefSeq; NP_217421.1; NC_000962.3.
DR   RefSeq; WP_003414720.1; NZ_NVQJ01000006.1.
DR   AlphaFoldDB; P9WK67; -.
DR   SMR; P9WK67; -.
DR   STRING; 83332.Rv2905; -.
DR   PaxDb; P9WK67; -.
DR   PRIDE; P9WK67; -.
DR   DNASU; 887421; -.
DR   GeneID; 45426892; -.
DR   GeneID; 887421; -.
DR   KEGG; mtu:Rv2905; -.
DR   TubercuList; Rv2905; -.
DR   eggNOG; COG2367; Bacteria.
DR   OMA; GRWFNTI; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.710.10; -; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   SUPFAM; SSF56601; SSF56601; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           23..314
FT                   /note="Putative lipoprotein LppW"
FT                   /id="PRO_0000018118"
FT   LIPID           23
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           23
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   314 AA;  33402 MW;  DE963F5F4C55154D CRC64;
     MRARPLTLLT ALAAVTLVVV AGCEARVEAE AYSAADRISS RPQARPQPQP VELLLRAITP
     PRAPAASPNV GFGELPTRVR QATDEAAAMG ATLSVAVLDR ATGQLVSNGN TQIIATASVA
     KLFIADDLLL AEAEGKVTLS PEDHHALDVM LQSSDDGAAE RFWSQDGGNA VVTQVARRYG
     LRSTAPPSDG RWWNTISSAP DLIRYYDMLL DGSGGLPLDR AAVIIADLAQ STPTGIDGYP
     QRFGIPDGLY AEPVAVKQGW MCCIGSSWMH LSTGVIGPER RYIMVIESLQ PADDATARAT
     ITQAVRTMFP NGRI