ID   LPPY_ECOLI              Reviewed;          44 AA.
AC   P0AD83; P09150; Q2M661;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=pyr operon leader peptide;
DE   AltName: Full=pyrBI operon attenuator;
GN   Name=pyrL; OrderedLocusNames=b4246, JW4205;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=3928602; DOI=10.1128/jb.163.3.991-999.1985;
RA   Roland K.L., Powell F.E., Turnbough C.L. Jr.;
RT   "Role of translation and attenuation in the control of pyrBI operon
RT   expression in Escherichia coli K-12.";
RL   J. Bacteriol. 163:991-999(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=6300835; DOI=10.1073/pnas.80.2.368;
RA   Turnbough C.L. Jr., Hicks K.L., Donahue J.P.;
RT   "Attenuation control of pyrBI operon expression in Escherichia coli K-12.";
RL   Proc. Natl. Acad. Sci. U.S.A. 80:368-372(1983).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=1699940; DOI=10.1016/s0021-9258(17)30629-4;
RA   Donahue J.P., Turnbough C.L. Jr.;
RT   "Characterization of transcriptional initiation from promoters P1 and P2 of
RT   the pyrBI operon of Escherichia coli K12.";
RL   J. Biol. Chem. 265:19091-19099(1990).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA   Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT   from 92.8 through 100 minutes.";
RL   Nucleic Acids Res. 23:2105-2119(1995).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
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DR   EMBL; M10743; AAA24478.1; -; Genomic_DNA.
DR   EMBL; M60508; AAA24480.1; -; Genomic_DNA.
DR   EMBL; U14003; AAA97143.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC77203.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78245.1; -; Genomic_DNA.
DR   PIR; A24926; LPECBI.
DR   RefSeq; NP_418667.1; NC_000913.3.
DR   RefSeq; WP_001296693.1; NZ_STEB01000013.1.
DR   AlphaFoldDB; P0AD83; -.
DR   BioGRID; 4262947; 11.
DR   STRING; 511145.b4246; -.
DR   PaxDb; P0AD83; -.
DR   PRIDE; P0AD83; -.
DR   EnsemblBacteria; AAC77203; AAC77203; b4246.
DR   EnsemblBacteria; BAE78245; BAE78245; BAE78245.
DR   GeneID; 67414871; -.
DR   GeneID; 948768; -.
DR   KEGG; ecj:JW4205; -.
DR   KEGG; eco:b4246; -.
DR   PATRIC; fig|83333.103.peg.555; -.
DR   EchoBASE; EB1256; -.
DR   eggNOG; ENOG5033C5D; Bacteria.
DR   HOGENOM; CLU_213745_0_0_6; -.
DR   BioCyc; EcoCyc:EG11279-MON; -.
DR   PRO; PR:P0AD83; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0019856; P:pyrimidine nucleobase biosynthetic process; IMP:EcoCyc.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IMP:EcoCyc.
DR   GO; GO:0031555; P:transcriptional attenuation; IMP:EcoCyc.
DR   InterPro; IPR012602; PyrBI_leader.
DR   Pfam; PF08052; PyrBI_leader; 1.
DR   PIRSF; PIRSF003249; PyrBI_leader; 1.
PE   4: Predicted;
KW   Leader peptide; Pyrimidine biosynthesis; Reference proteome.
FT   CHAIN           1..44
FT                   /note="pyr operon leader peptide"
FT                   /id="PRO_0000196521"
SQ   SEQUENCE   44 AA;  5098 MW;  57963426EC457005 CRC64;
     MVQCVRHFVL PRLKKDAGLP FFFPLITHSQ PLNRGAFFCP GVRR