ID   LPP_MORMO               Reviewed;          78 AA.
AC   P02940;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Major outer membrane lipoprotein Lpp {ECO:0000255|HAMAP-Rule:MF_00843};
DE   Flags: Precursor;
GN   Name=lpp {ECO:0000255|HAMAP-Rule:MF_00843};
OS   Morganella morganii (Proteus morganii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Morganella.
OX   NCBI_TaxID=582;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6305973; DOI=10.1016/s0021-9258(20)82039-0;
RA   Huang Y.-X., Ching G., Inouye M.;
RT   "Comparison of the lipoprotein gene among the enterobacteriaceae. DNA
RT   sequence of Morganella morganii lipoprotein gene and its expression in
RT   Escherichia coli.";
RL   J. Biol. Chem. 258:8139-8145(1983).
CC   -!- FUNCTION: A highly abundant outer membrane lipoprotein that controls
CC       the distance between the inner and outer membranes. The only protein
CC       known to be covalently linked to the peptidoglycan network (PGN). Also
CC       non-covalently binds the PGN. The link between the cell outer membrane
CC       and PGN contributes to maintenance of the structural and functional
CC       integrity of the cell envelope, and maintains the correct distance
CC       between the PGN and the outer membrane. {ECO:0000255|HAMAP-
CC       Rule:MF_00843}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000255|HAMAP-Rule:MF_00843}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00843}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_00843};
CC       Periplasmic side {ECO:0000255|HAMAP-Rule:MF_00843}. Secreted, cell wall
CC       {ECO:0000255|HAMAP-Rule:MF_00843}; Peptidoglycan-anchor
CC       {ECO:0000255|HAMAP-Rule:MF_00843}. Note=Attached via its lipidated N-
CC       terminus to the inner leaflet of the outer membrane. Attached to the
CC       peptidoglycan network (PGN) via its C-terminus. {ECO:0000255|HAMAP-
CC       Rule:MF_00843}.
CC   -!- SIMILARITY: Belongs to the Lpp family. {ECO:0000255|HAMAP-
CC       Rule:MF_00843}.
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DR   EMBL; K00084; AAA25322.1; -; Genomic_DNA.
DR   PIR; A03440; LPEBWM.
DR   RefSeq; WP_004239093.1; NZ_WJFN01000003.1.
DR   AlphaFoldDB; P02940; -.
DR   SMR; P02940; -.
DR   STRING; 582.AL531_07505; -.
DR   GeneID; 67497970; -.
DR   OrthoDB; 1991143at2; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0042834; F:peptidoglycan binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030258; P:lipid modification; IEA:UniProtKB-UniRule.
DR   GO; GO:0043580; P:periplasmic space organization; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00843; Lpp; 1.
DR   InterPro; IPR006817; Lipoprotein_leucine-zipper_dom.
DR   InterPro; IPR016367; MOM_Lpp.
DR   PANTHER; PTHR38763; PTHR38763; 1.
DR   Pfam; PF04728; LPP; 1.
DR   PIRSF; PIRSF002855; Murein-lipoprotein; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Cell wall; Coiled coil; Lipoprotein; Membrane;
KW   Palmitate; Peptidoglycan-anchor; Repeat; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00843"
FT   CHAIN           21..78
FT                   /note="Major outer membrane lipoprotein Lpp"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00843"
FT                   /id="PRO_0000018336"
FT   REPEAT          24..34
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00843"
FT   REPEAT          38..48
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00843"
FT   COILED          27..75
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00843"
FT   MOD_RES         78
FT                   /note="N6-murein peptidoglycan lysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00843"
FT   LIPID           21
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00843"
FT   LIPID           21
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00843"
SQ   SEQUENCE   78 AA;  8431 MW;  2BB4EC7DF2164543 CRC64;
     MGRSKIVLGA VVLASALLAG CSSNAKFDQL DNDVKTLNAK VDQLSNDVNA IRADVQQAKD
     EAARANQRLD NQVRSYKK