LPQB_MYCS2
ID LPQB_MYCS2 Reviewed; 585 AA.
AC A0QTK4; I7G6N1;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Lipoprotein LpqB {ECO:0000255|HAMAP-Rule:MF_01373};
DE Flags: Precursor;
GN Name=lpqB {ECO:0000255|HAMAP-Rule:MF_01373};
GN OrderedLocusNames=MSMEG_1876, MSMEI_1837;
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT mutations or sequencing errors?";
RL Genome Biol. 8:R20.1-R20.9(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=18955433; DOI=10.1101/gr.081901.108;
RA Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT and a new MS-based protocol.";
RL Genome Res. 19:128-135(2009).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=20233304; DOI=10.1111/j.1365-2958.2010.07110.x;
RA Nguyen H.T., Wolff K.A., Cartabuke R.H., Ogwang S., Nguyen L.;
RT "A lipoprotein modulates activity of the MtrAB two-component system to
RT provide intrinsic multidrug resistance, cytokinetic control and cell wall
RT homeostasis in Mycobacterium.";
RL Mol. Microbiol. 76:348-364(2010).
CC -!- FUNCTION: May modulate activity of the MtrAB system in controlling
CC homeostasis of the cell wall and cell division.
CC {ECO:0000269|PubMed:20233304}.
CC -!- SUBUNIT: Interacts with MtrB, probably extracytoplasmically via its
CC sensor domain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:20233304};
CC Lipid-anchor {ECO:0000305|PubMed:20233304}. Secreted, cell wall
CC {ECO:0000269|PubMed:20233304}.
CC -!- DISRUPTION PHENOTYPE: Increased antibiotic susceptibility, altered
CC colony morphology and increased aggregation, increased uptake of the
CC Congo Red stain and increased sensitivity to SDS. Decreased gliding
CC motility and biofilm formation. Cells are very long, sometimes branched
CC and often polyploid. Decreased phosphorylation of MtrA, increased
CC expression of dnaA in early growth stages.
CC {ECO:0000269|PubMed:20233304}.
CC -!- SIMILARITY: Belongs to the LpqB lipoprotein family. {ECO:0000255|HAMAP-
CC Rule:MF_01373}.
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DR EMBL; CP000480; ABK72170.1; -; Genomic_DNA.
DR EMBL; CP001663; AFP38309.1; -; Genomic_DNA.
DR RefSeq; WP_011727973.1; NZ_SIJM01000020.1.
DR RefSeq; YP_886242.1; NC_008596.1.
DR AlphaFoldDB; A0QTK4; -.
DR SMR; A0QTK4; -.
DR STRING; 246196.MSMEI_1837; -.
DR PRIDE; A0QTK4; -.
DR EnsemblBacteria; ABK72170; ABK72170; MSMEG_1876.
DR EnsemblBacteria; AFP38309; AFP38309; MSMEI_1837.
DR GeneID; 66733312; -.
DR KEGG; msg:MSMEI_1837; -.
DR KEGG; msm:MSMEG_1876; -.
DR PATRIC; fig|246196.19.peg.1858; -.
DR eggNOG; COG5401; Bacteria.
DR OMA; CASMPDS; -.
DR OrthoDB; 796522at2; -.
DR Proteomes; UP000000757; Chromosome.
DR Proteomes; UP000006158; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_01373; LpqB_lipoprot; 1.
DR InterPro; IPR019606; GerMN.
DR InterPro; IPR023959; Lipoprotein_LpqB.
DR InterPro; IPR018910; Lipoprotein_LpqB_C.
DR Pfam; PF10646; Germane; 1.
DR Pfam; PF10647; Gmad1; 1.
DR SMART; SM00909; Germane; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell wall; Lipoprotein; Membrane; Palmitate;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01373"
FT CHAIN 19..585
FT /note="Lipoprotein LpqB"
FT /id="PRO_0000286723"
FT REGION 24..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 19
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01373"
FT LIPID 19
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01373"
SQ SEQUENCE 585 AA; 61398 MW; 01C54E2CDDED1C37 CRC64;
MKRLLTVLVV GLVALVSGCA GIPSSSSPQA IGTVERPAPP SLPKPTPDMD PDVLLREFLK
ATADPANRHL AARQFLTESA SSAWDDAGSA LLIDRVVFVE TRSTDRVSVS MRADILGSLS
DLGVFETGEG ALPDPGPIEL VKTSGGWRID RLPNGVFLDW QQFQATYKRY TLYFVDPTGT
TVVPDPRYVA VSDPDQLATE LVSKLIAGPR PEMERSVRNL LDPPLKLRGP VTRADGGKTG
VGRGYGGARI DLENLSASDP HSRQLLAAQL IWTLSRAGVA GPYVINVDGA PLDDRFADGW
ETSDVAATDP GAAPGAAAGL HALVNGSLVS LDGQRAPRVP GAFGQAPHQV SASVSRNGQD
AASVVAPPGA PDPAATLWIG PLGGSTVQAM EGRTLSRPSW SLDQAVWVVA DGINVVRAIR
DASGTPARIP VDSSAVSSRY PGPISDLQLS RDGTRAAMVI EGQVILAGIE QTQDGRFLLT
YPRRLGFGLG NSAVSLSWRT GDDIVVSRTD PEHPVSYVNL DGVNSDAPSR NLVMPVSVVA
ANPSTVYVAD QRGVKQLSAS ADEENSGWVE VSPLMVPGSL PVLPG
