ID   LPQB_MYCTU              Reviewed;         587 AA.
AC   P9WK37; L0TC87; O05889; Q7D5U9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Lipoprotein LpqB {ECO:0000255|HAMAP-Rule:MF_01373};
DE   Flags: Precursor;
GN   Name=lpqB {ECO:0000255|HAMAP-Rule:MF_01373}; OrderedLocusNames=Rv3244c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH MTRB.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=20233304; DOI=10.1111/j.1365-2958.2010.07110.x;
RA   Nguyen H.T., Wolff K.A., Cartabuke R.H., Ogwang S., Nguyen L.;
RT   "A lipoprotein modulates activity of the MtrAB two-component system to
RT   provide intrinsic multidrug resistance, cytokinetic control and cell wall
RT   homeostasis in Mycobacterium.";
RL   Mol. Microbiol. 76:348-364(2010).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: May modulate activity of the MtrAB system in controlling
CC       homeostasis of the cell wall and cell division (By similarity).
CC       Partially restores antibiotic resistance to M.smegmatis in which this
CC       gene has been disrupted. {ECO:0000250, ECO:0000269|PubMed:20233304}.
CC   -!- SUBUNIT: Interacts with MtrB, probably extracytoplasmically.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:20233304};
CC       Lipid-anchor {ECO:0000305|PubMed:20233304}. Secreted, cell wall
CC       {ECO:0000269|PubMed:20233304}.
CC   -!- SIMILARITY: Belongs to the LpqB lipoprotein family. {ECO:0000255|HAMAP-
CC       Rule:MF_01373}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCP46063.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL123456; CCP46063.1; ALT_INIT; Genomic_DNA.
DR   PIR; F70592; F70592.
DR   RefSeq; NP_217761.1; NC_000962.3.
DR   AlphaFoldDB; P9WK37; -.
DR   SMR; P9WK37; -.
DR   STRING; 83332.Rv3244c; -.
DR   PaxDb; P9WK37; -.
DR   DNASU; 888815; -.
DR   GeneID; 888815; -.
DR   KEGG; mtu:Rv3244c; -.
DR   TubercuList; Rv3244c; -.
DR   eggNOG; COG5401; Bacteria.
DR   OMA; CASMPDS; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   HAMAP; MF_01373; LpqB_lipoprot; 1.
DR   InterPro; IPR019606; GerMN.
DR   InterPro; IPR023959; Lipoprotein_LpqB.
DR   InterPro; IPR018910; Lipoprotein_LpqB_C.
DR   Pfam; PF10646; Germane; 1.
DR   Pfam; PF10647; Gmad1; 1.
DR   SMART; SM00909; Germane; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Cell wall; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01373"
FT   CHAIN           20..587
FT                   /note="Lipoprotein LpqB"
FT                   /id="PRO_0000286724"
FT   LIPID           20
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01373"
FT   LIPID           20
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01373"
SQ   SEQUENCE   587 AA;  61681 MW;  1E2C7D25A2C5D91B CRC64;
     MERLMRLTIL LFLGAVLAGC ASVPSTSAPQ AIGTVERPVP SNLPKPSPGM DPDVLLREFL
     KATADPANRH LAARQFLTES ASNAWDDAGS ALLIDHVVFV ETRSAEKVSV TMRADILGSL
     SDVGVFETAE GQLPDPGPIE LVKTSDGWRI DRLPNGVFLD WQQFQETYKR NTLYFADPTG
     KTVVPDPRYV AVSDRDQLAT ELVSKLLAGP RPEMARTVRN LLAPPLRLRG PVTRADGGKS
     GIGRGYGGAR VDMEKLSTTD PHSRQLLAAQ IIWTLARADI RGPYVINADG APLEDRFAEG
     WTTSDVAATD PGVADGAAAG LHALVNGSLV AMDAQRVTPV PGAFGRMPEQ TAAAVSRSGR
     QVASVVTLGR GAPDEAASLW VGDLGGEAVQ SADGHSLSRP SWSLDDAVWV VVDTNVVLRA
     IQDPASGQPA RIPVDSTAVA SRFPGAINDL QLSRDGTRAA MVIGGQVILA GVEQTQAGQF
     ALTYPRRLGF GLGSSVVSLS WRTGDDIVVT RTDAAHPVSY VNLDGVNSDA PSRGLQTPLT
     AIAANPSTVY VAGPQGVLMY SASVESRPGW ADVPGLMVPG AAPVLPG