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LPQH_MYCAV
ID   LPQH_MYCAV              Reviewed;         161 AA.
AC   P46733;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Lipoprotein LpqH;
DE   AltName: Full=19 kDa lipoprotein antigen;
DE   AltName: Full=Putative transporter LpqH;
DE   Flags: Precursor;
GN   Name=lpqH;
OS   Mycobacterium avium.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=1764;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Serovar 2;
RX   PubMed=8454357; DOI=10.1128/iai.61.4.1509-1515.1993;
RA   Booth R.J., Williams D.L., Moudgil K.D., Noonan L.C., Grandison P.M.,
RA   McKee J.J., Prestidge R.L., Watson J.D.;
RT   "Homologs of Mycobacterium leprae 18-kilodalton and Mycobacterium
RT   tuberculosis 19-kilodalton antigens in other mycobacteria.";
RL   Infect. Immun. 61:1509-1515(1993).
CC   -!- FUNCTION: Might be involved in ligand transport. A host TLR2 agonist,
CC       modifies host gene expression in response to pathogen.
CC       {ECO:0000250|UniProtKB:P9WK61}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- DOMAIN: Forms a U-shaped beta-half-barrel with a large hydrophobic
CC       cavity. {ECO:0000250|UniProtKB:P9WK61}.
CC   -!- PTM: Modified by Lgt on Cys-22 with an S-linked diacylglycerol with a
CC       mixture of C16, C18 and C19 fatty acids, signal peptide is removed by
CC       LspA, modifed by Lnt with an amide-linked mixture of C16 and C19 fatty
CC       acids. {ECO:0000250|UniProtKB:P9WK61}.
CC   -!- SIMILARITY: Belongs to the mycobacterial 19 kDa antigen family.
CC       {ECO:0000305}.
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DR   EMBL; L12235; AAA25346.1; -; Genomic_DNA.
DR   AlphaFoldDB; P46733; -.
DR   SMR; P46733; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008691; LpqH.
DR   Pfam; PF05481; Myco_19_kDa; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Signal; Transport;
KW   Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000305"
FT   CHAIN           22..161
FT                   /note="Lipoprotein LpqH"
FT                   /id="PRO_0000018125"
FT   REGION          21..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           22
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           22
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   161 AA;  15504 MW;  78A180B1A1C100E4 CRC64;
     MNRQLRFAVA GPEILAAVVS GCSSGNKSAP SSSASSSSTS PSASSGGAAG TKVIIDGKDQ
     NVSGSVVCTN AGGTVNIAIG GAATGIAAVL SDGNPPQVKS VGLGNVNGVT LGYTSGTGQG
     NASAEKNGNS YKITGTATGV DMANPLQPVN KPFEIDVTCN S
 
 
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