LPQH_MYCAV
ID LPQH_MYCAV Reviewed; 161 AA.
AC P46733;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Lipoprotein LpqH;
DE AltName: Full=19 kDa lipoprotein antigen;
DE AltName: Full=Putative transporter LpqH;
DE Flags: Precursor;
GN Name=lpqH;
OS Mycobacterium avium.
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=1764;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Serovar 2;
RX PubMed=8454357; DOI=10.1128/iai.61.4.1509-1515.1993;
RA Booth R.J., Williams D.L., Moudgil K.D., Noonan L.C., Grandison P.M.,
RA McKee J.J., Prestidge R.L., Watson J.D.;
RT "Homologs of Mycobacterium leprae 18-kilodalton and Mycobacterium
RT tuberculosis 19-kilodalton antigens in other mycobacteria.";
RL Infect. Immun. 61:1509-1515(1993).
CC -!- FUNCTION: Might be involved in ligand transport. A host TLR2 agonist,
CC modifies host gene expression in response to pathogen.
CC {ECO:0000250|UniProtKB:P9WK61}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
CC -!- DOMAIN: Forms a U-shaped beta-half-barrel with a large hydrophobic
CC cavity. {ECO:0000250|UniProtKB:P9WK61}.
CC -!- PTM: Modified by Lgt on Cys-22 with an S-linked diacylglycerol with a
CC mixture of C16, C18 and C19 fatty acids, signal peptide is removed by
CC LspA, modifed by Lnt with an amide-linked mixture of C16 and C19 fatty
CC acids. {ECO:0000250|UniProtKB:P9WK61}.
CC -!- SIMILARITY: Belongs to the mycobacterial 19 kDa antigen family.
CC {ECO:0000305}.
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DR EMBL; L12235; AAA25346.1; -; Genomic_DNA.
DR AlphaFoldDB; P46733; -.
DR SMR; P46733; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008691; LpqH.
DR Pfam; PF05481; Myco_19_kDa; 1.
PE 3: Inferred from homology;
KW Cell membrane; Lipoprotein; Membrane; Palmitate; Signal; Transport;
KW Virulence.
FT SIGNAL 1..21
FT /evidence="ECO:0000305"
FT CHAIN 22..161
FT /note="Lipoprotein LpqH"
FT /id="PRO_0000018125"
FT REGION 21..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 22
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000305"
FT LIPID 22
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000305"
SQ SEQUENCE 161 AA; 15504 MW; 78A180B1A1C100E4 CRC64;
MNRQLRFAVA GPEILAAVVS GCSSGNKSAP SSSASSSSTS PSASSGGAAG TKVIIDGKDQ
NVSGSVVCTN AGGTVNIAIG GAATGIAAVL SDGNPPQVKS VGLGNVNGVT LGYTSGTGQG
NASAEKNGNS YKITGTATGV DMANPLQPVN KPFEIDVTCN S