LPQH_MYCBO
ID LPQH_MYCBO Reviewed; 159 AA.
AC P0A5J1; A0A1R3Y556; P11572; X2BQ19;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Lipoprotein LpqH;
DE AltName: Full=19 kDa lipoprotein antigen;
DE AltName: Full=Putative transporter LpqH;
DE Flags: Precursor;
GN Name=lpqH; OrderedLocusNames=BQ2027_MB3789;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate 381/79;
RX PubMed=2230723; DOI=10.1099/00221287-136-7-1429;
RA Collins M., Patki A., Wall S., Nolan A., Goodger J., Woodward M., Dale J.;
RT "Cloning and characterization of the gene for the '19 kDa' antigen of
RT Mycobacterium bovis.";
RL J. Gen. Microbiol. 136:1429-1436(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- FUNCTION: Might be involved in ligand transport. A host TLR2 agonist,
CC modifies host gene expression in response to pathogen.
CC {ECO:0000250|UniProtKB:P9WK61}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
CC -!- DOMAIN: Forms a U-shaped beta-half-barrel with a large hydrophobic
CC cavity. {ECO:0000250|UniProtKB:P9WK61}.
CC -!- PTM: Modified by Lgt on Cys-22 with an S-linked diacylglycerol with a
CC mixture of C16, C18 and C19 fatty acids, signal peptide is removed by
CC LspA, modifed by Lnt with an amide-linked mixture of C16 and C19 fatty
CC acids. {ECO:0000250|UniProtKB:P9WK61}.
CC -!- SIMILARITY: Belongs to the mycobacterial 19 kDa antigen family.
CC {ECO:0000305}.
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DR EMBL; X15803; CAA33802.1; -; Genomic_DNA.
DR EMBL; LT708304; SIU02418.1; -; Genomic_DNA.
DR PIR; S11234; S11234.
DR RefSeq; NP_857426.1; NC_002945.3.
DR RefSeq; WP_003420544.1; NC_002945.4.
DR AlphaFoldDB; P0A5J1; -.
DR SMR; P0A5J1; -.
DR EnsemblBacteria; SIU02418; SIU02418; BQ2027_MB3789.
DR GeneID; 45427763; -.
DR PATRIC; fig|233413.5.peg.4145; -.
DR OMA; CSDMGGN; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008691; LpqH.
DR Pfam; PF05481; Myco_19_kDa; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Lipoprotein; Membrane; Palmitate; Signal; Transport;
KW Virulence.
FT SIGNAL 1..21
FT /evidence="ECO:0000305"
FT CHAIN 22..159
FT /note="Lipoprotein LpqH"
FT /id="PRO_0000018126"
FT REGION 24..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 22
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000305"
FT LIPID 22
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000305"
SQ SEQUENCE 159 AA; 15147 MW; CB1A5090E14867BB CRC64;
MKRGLTVAVA GAAILVAGLS GCSSNKSTTG SGETTTAAGT TASPGAASGP KVVIDGKDQN
VTGSVVCTTA AGNVNIAIGG AATGIAAVLT DGNPPEVKSV GLGNVNGVTL GYTSGTGQGN
ASATKDGSHY KITGTATGVD MANPMSPVNK SFEIEVTCS