ID   LPQH_MYCTO              Reviewed;         159 AA.
AC   P9WK60; L0TGP1; P0A5J0; P11572;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Lipoprotein LpqH;
DE   AltName: Full=19 kDa lipoprotein antigen;
DE   AltName: Full=Putative transporter LpqH;
DE   Flags: Precursor;
GN   Name=lpqH; OrderedLocusNames=MT3870;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Might be involved in ligand transport. A host TLR2 agonist,
CC       modifies host gene expression in response to pathogen.
CC       {ECO:0000250|UniProtKB:P9WK61}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- DOMAIN: Forms a U-shaped beta-half-barrel with a large hydrophobic
CC       cavity. {ECO:0000250|UniProtKB:P9WK61}.
CC   -!- PTM: Modified by Lgt on Cys-22 with an S-linked diacylglycerol with a
CC       mixture of C16, C18 and C19 fatty acids, signal peptide is removed by
CC       LspA, modifed by Lnt with an amide-linked mixture of C16 and C19 fatty
CC       acids. {ECO:0000250|UniProtKB:P9WK61}.
CC   -!- SIMILARITY: Belongs to the mycobacterial 19 kDa antigen family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK48234.1; -; Genomic_DNA.
DR   PIR; D70801; D70801.
DR   RefSeq; WP_003917838.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WK60; -.
DR   SMR; P9WK60; -.
DR   EnsemblBacteria; AAK48234; AAK48234; MT3870.
DR   KEGG; mtc:MT3870; -.
DR   PATRIC; fig|83331.31.peg.4165; -.
DR   HOGENOM; CLU_117599_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008691; LpqH.
DR   Pfam; PF05481; Myco_19_kDa; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Signal; Transport;
KW   Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000305"
FT   CHAIN           22..159
FT                   /note="Lipoprotein LpqH"
FT                   /id="PRO_0000427710"
FT   REGION          24..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           22
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           22
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   159 AA;  15131 MW;  CB015090E14867BB CRC64;
     MKRGLTVAVA GAAILVAGLS GCSSNKSTTG SGETTTAAGT TASPGAASGP KVVIDGKDQN
     VTGSVVCTTA AGNVNIAIGG AATGIAAVLT DGNPPEVKSV GLGNVNGVTL GYTSGTGQGN
     ASATKDGSHY KITGTATGVD MANPMSPVNK SFEIEVTSS