ID   LPQY_MYCTO              Reviewed;         468 AA.
AC   P9WGU8; F2GFS7; L0T620; Q7ARU8; Q7D8J9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Trehalose-binding lipoprotein LpqY;
DE   Flags: Precursor;
GN   Name=lpqY; OrderedLocusNames=MT1273;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Part of the ABC transporter complex LpqY-SugA-SugB-SugC,
CC       which is highly specific for uptake of trehalose. Involved in the
CC       recycling of extracellular trehalose released from trehalose-containing
CC       molecules synthesized by M.tuberculosis. Trehalose uptake is essential
CC       for virulence (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (SugC),
CC       two transmembrane proteins (Suga and SugB) and a solute-binding protein
CC       (LpqY). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK45531.1; -; Genomic_DNA.
DR   RefSeq; WP_003898783.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGU8; -.
DR   SMR; P9WGU8; -.
DR   EnsemblBacteria; AAK45531; AAK45531; MT1273.
DR   GeneID; 45425205; -.
DR   KEGG; mtc:MT1273; -.
DR   PATRIC; fig|83331.31.peg.1376; -.
DR   HOGENOM; CLU_031285_9_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006059; SBP.
DR   Pfam; PF01547; SBP_bac_1; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Signal; Sugar transport;
KW   Transport.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           26..468
FT                   /note="Trehalose-binding lipoprotein LpqY"
FT                   /id="PRO_0000428299"
FT   LIPID           26
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           26
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   468 AA;  49793 MW;  D2F5A20A706680CA CRC64;
     MVMSRGRIPR LGAAVLVALT TAAAACGADS QGLVVSFYTP ATDGATFTAI AQRCNQQFGG
     RFTIAQVSLP RSPNEQRLQL ARRLTGNDRT LDVMALDVVW TAEFAEAGWA LPLSDDPAGL
     AENDAVADTL PGPLATAGWN HKLYAAPVTT NTQLLWYRPD LVNSPPTDWN AMIAEAARLH
     AAGEPSWIAV QANQGEGLVV WFNTLLVSAG GSVLSEDGRH VTLTDTPAHR AATVSALQIL
     KSVATTPGAD PSITRTEEGS ARLAFEQGKA ALEVNWPFVF ASMLENAVKG GVPFLPLNRI
     PQLAGSINDI GTFTPSDEQF RIAYDASQQV FGFAPYPAVA PGQPAKVTIG GLNLAVAKTT
     RHRAEAFEAV RCLRDQHNQR YVSLEGGLPA VRASLYSDPQ FQAKYPMHAI IRQQLTDAAV
     RPATPVYQAL SIRLAAVLSP ITEIDPESTA DELAAQAQKA IDGMGLLP