ID   LPRA_MYCTO              Reviewed;         244 AA.
AC   P9WK54; L0T656; Q11049;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Putative lipoprotein LprA;
DE   Flags: Precursor;
GN   Name=lprA; OrderedLocusNames=MT1308;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the LppX/LprAFG lipoprotein family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK45568.1; -; Genomic_DNA.
DR   PIR; F70754; F70754.
DR   RefSeq; WP_003406562.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WK54; -.
DR   SMR; P9WK54; -.
DR   EnsemblBacteria; AAK45568; AAK45568; MT1308.
DR   KEGG; mtc:MT1308; -.
DR   PATRIC; fig|83331.31.peg.1413; -.
DR   HOGENOM; CLU_074100_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd16334; LppX-like; 1.
DR   InterPro; IPR029046; LolA/LolB/LppX.
DR   InterPro; IPR009830; LppX/LprAFG.
DR   Pfam; PF07161; LppX_LprAFG; 1.
DR   SUPFAM; SSF89392; SSF89392; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           25..244
FT                   /note="Putative lipoprotein LprA"
FT                   /id="PRO_0000427713"
FT   LIPID           25
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           25
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   244 AA;  24874 MW;  566C3A1459622BD8 CRC64;
     MKHPPCSVVA AATAILAVVL AIGGCSTEGD AGKASDTAAT ASNGDAAMLL KQATDAMRKV
     TGMHVRLAVT GDVPNLRVTK LEGDISNTPQ TVATGSATLL VGNKSEDAKF VYVDGHLYSD
     LGQPGTYTDF GNGASIYNVS VLLDPNKGLA NLLANLKDAS VAGSQQADGV ATTKITGNSS
     ADDIATLAGS RLTSEDVKTV PTTVWIASDG SSHLVQIQIA PTKDTSVTLT MSDWGKQVTA
     TKPV